Is Jeera Water Good For Weight Loss
Jeera water is said to aid digestion and improve bowel movement. It secretes enzymes, which help in breaking down sugars, fats and carbohydrates that keep the gut healthy. A good digestive system is the key to losing weight effectively. Better digestion further helps in improving metabolic rate, leading to weight loss.
Crystal Violet Staining Assay
In the crystal violet staining cell adhesion assay, the cells were treated with the selected doses of FSE for 48 hours, as stated above. The cells were gently washed and stained with 0.2% crystal violet in 10% formalin solution. Then, the staining solution was removed, and the cells were washed 3X with phosphate-buffered saline and were air-dried for taking macrographic images.
Can We Drink Methi Water Daily
Chew methi seeds at least twice or thrice a day and you will discover you feel satiated without eating much. Another technique for weight reduction is drinking two glasses of methi water in the morning. This water is exceptionally useful in prevention of water retention in the body as well as bloating.
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Polyphenols In Fse And Antioxidant Activity
The concentration of polyphenols as total phenolic contents and total flavonoid contents in FSE was measured to be 128.3 and 14.93 µg/g of extract . The antioxidant activity of FSE was found to be increasing in dose depending manner. As depicted in Figure 1B, the IC50 value as 50% radical scavenging activity was observed at 19 µg/mL of FSE .
Figure 2 Concentration of polyphenols in FSE and antioxidant activity.
Abbreviations: FSE, fenugreek seed extract TPC, total phenolic contents TFC, total flavonoid contents DPPH, 2,2-diphenyl-1-picrylhydrazyl SEM, standard error mean.
Notes: TPC and TFC. The antioxidant activity as percentage of DPPH radical inhibition and IC50 value . The data represented mean value cells ± SEM of three independent experiments.
Fenugreek Oil Side Effects
Yes, the real issues occur when using fenugreek oil.
And here, Im talking about fenugreek essential oil since its highly concentrated and can cause severe damages to the skin when applied directly.
This is probably one of the few occasions where I do not recommend using fenugreek since its essential oil can be devastating on the skin if you dont know how to take advantage of it.
As a rule of thumb, always start small, use one drop on the back of your hand, test it and see after some few hours whether your skin will inflame or not.
If it does, then you need to understand that you are dealing with a very powerful kind of fenugreek oil and it can cause your skin damages if used on a large portion of your body.
One more thing, most fenugreek essential oil sold nowadays isnt 100% pure in other words, its usually mixed with other non-essential oils like olive or grapeseed.
This means that most of the time, its very safe to use it, however, if, after doing the little test I have just talked about, you found that your skin is sensitive to fenugreek oil, then you need to dilute it yourself in a good carrier oil, olive oil and coconut oil are the best.
Always respect this ratio to stay clear from trouble: 1 to 5.
For each drop of essential oil you use, you need to add five drops of olive oil or the carrier oil of your choice.
This way, youll stay clear of trouble no matter how much concentrated your fenugreek oil is.
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Which Brand Of Coconut Oil Is The Best
Let us now go through the top 10 best virgin coconut oilbrands in India that offer the highest quality coconut oil at thebest prices.
- Nutiva Organic Virgin Coconut Oil.
- Kama Ayurveda Extra Virgin Organic Coconut Oil.
- Forest Essentials Organic Cold Pressed Coconut Virgin Oil.
- Organic India Extra Virgin Coconut Oil.
Detection Of Cell Death
To confirm cell death, the Ethidium bromide-calcein cytotoxic assay was performed as per manufacturer’s instructions. In brief, DU-145 and PC-3 PCa cells, and hTert-PrEC and PrEC were plated in 6-well dishes and incubated with or without agents: sulforaphane , diosgenin and FE – doses that are cytotoxic for the cancer cells as determined by the MTT assay. After 96h incubation, the wells were washed with PBS. A mixture of Calcein AM and EthD-III was added to the cells and allowed to incubate for 15min at 37°C. The cells were then visualized within the hour with a fluorescence microscope.
Fse Induced Cytotoxicity In Mcf
The cell viability was evaluated on MCF-7 and SK-BR3 breast cancer cells by the cell cytotoxicity assay following 48 hours of treatment with various concentrations of FSE. As depicted in Figure 3, both of the cell lines responded to the anti-proliferative and cytotoxic effects of FSE in a dose-dependent manner. It induced the cell proliferation within the range of 110 µg/mL, whereas started the growth inhibition at 25 µg/mL of FSE in MCF7 cells, and IC50 was observed at 150 µg/mL . The induction of cell proliferation was recorded at only 12 µg/mL in SK-BR3 cells, though it initiated the cytotoxic effect of cell death at 5 µg/mL. The SKBR3 cell showed potent cytotoxic activity as the IC50 was measured at 40 µg/mL . This primary screening of both of the cells helped us to select the four different doses for each cell line for further studies that showed the viability of the cells from 90 to 50%. The four doses that showed IC10, IC25, IC35, IC50 for the MCF-7 and SK-BR3 cells were selected and designated as follows: 40 , 80 , 100 and 150 µg/mL and 10 , 20 , 30 and 40 µg/mL , respectively.
Figure 3 The analysis of cell viability by cell cytotoxicity assay.
Notes: MCF-7 and SKBR3 cells were treated with a range of FSE doses for 48 hours in 96 well plates, and the percentage of cell viability was measured by cell cytotoxicity assay kit. Data represented mean percentages of viable cells ± SEM of three independent experiments.
What Is Fibrocystic Breast Disease
Dietary guidelines Increase consumption of vegetables, especially the cruciferous family . Eat fibrous fruits like apple, pear, orange, sweetlime, papaya, melon etc, vegetables like spinach, fenugreek leaves, beans and peas which are rich in fibre as well as B complex vitamins. Raw seeds like flaxseeds, black til, nuts like almonds, walnuts, whole grains cereals like wheat, millet, ragi, oats etc should also be consumed. Eating these foods will change your biochemistry and may help prevent cyclical fluctuations in the cyst size and tenderness.The addition of seafood to the diet, particularly fish high in the Omega-3 fatty acids like salmon, trout and mackerel may be useful in preventing breast cysts . Vitamin A has been found to be useful in reducing both the pain symptoms and the size of the breast lesions in women with fibrocystic breast disease. Therefore consumption of beta carotene found abundantly in many yellow, orange, red, and dark green fruits and vegetables is beneficial. Vitamin E is also found to be quite helpful in reducing the pain and tenderness, as well as the size of breast lumps.
Diets high in fat, with meat and dairy products contribute to the formation of painful lumps. Caffeine in coffee, colas and energy drinks, theophylline in tea, theobromine in chocolate have also shown to contribute to this inflammation and should be reduced or eliminated from the diet.
Can You Start Taking Fenugreek While Pregnant
Fenugreekduring pregnancyfenugreekfenugreekduring pregnancy
. Moreover, can fenugreek seeds cause miscarriage?
Untoward effect of fenugreek. Large amounts of fenugreek may cause uterine contractions, miscarriage or premature labour. It could affect blood sugar levels, so pregnant women with insulin-dependent diabetes mellitus should avoid it.
One may also ask, when can I start taking fenugreek? We typically recommend that moms wait to begin taking our breastfeeding supplements until around 5 days after they deliver their baby.
In this way, does fenugreek cause birth defects?
However, consumption of fenugreek seeds during pregnancy has been associated with congenital malformations, neonatal and birth defects . Oral treatment with the fenugreek seeds aqueous extract also causes reproductive and developmental toxicity .
How much fenugreek should I take for breast enlargement?
Fenugreek is used as a ground seed in capsule form, or in tea, to increase milk production. The tea is weaker than the capsule form. The dose is 2-3 capsules , taken by mouth 3 times/day. Taking a lesser dose may not increase supply.
Raise Testosterone And Boost Sperm Count
Fenugreek may help increase low testosterone and sperm levels.
In a , 50 male volunteers took an extract of fenugreek seeds for 12 weeks. About 85 percent of the participants had an increased sperm count.
The results also indicate that the extract consistently improved mental alertness, mood, and libido.
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Does Fenugreek Affect Hormones
Earlier reports show that fenugreek seeds provide a mastogenic effect resulting in enhanced breast size. However, very little is known about its estrogenic effect. It also induced the expression of estrogen responsive gene pS2 in MCF-7 cells.
Additionally, does fenugreek affect menstrual cycle? Fenugreek seeds contain phytoestrogens . The researchers studied the effects of fenugreek on the severity of dysmenorrhea in 101 students. This was a double-blind, randomized, placebo controlled trial. The subjects had moderate-to-severe dysmenorrhea and the study lasted through two menstrual cycles.
People also ask, what are the side effects of fenugreek?
Side effects of Fenugreek include:
- Allergic reaction.
- Loss of consciousness
Is fenugreek good for thyroid patients?
Fenugreek’s most studied and employed effect is its hypoglycemic property, but it can also be useful for the treatment of certain thyroid disorders or for the treatment of anorexia. Moreover, fenugreek seeds showed the ability to reduce the thyroid hormone levels at the periphery and to modify the T4/T3 ratio.
What About Fenugreek Causing Breast Pain
Breast pain is a known side effect of high fenugreek intake.
Although fenugreek is one of the best herbs to take for breast cysts and other breast issues, some women may have breast pain when taking it daily for the first few weeks after all, not all women react the same way to fenugreek daily intake.
Yes, fenugreek intake may result in breast pain, but only temporary.
This is very important for you to be aware of because most women are going to be freaked out during the first weeks of fenugreek intake.
some have even e-mailed me with some very scary subject lines such as these: my period has disappeared or the bleeding wont stop
During the first few weeks of fenugreek intake, especially if youd like to increase your breasts size.
You are going to notice that your breasts and nipples are going to become very sensitive, your period is going to last much longer, and you may even feel discomfort in your breasts or pain.
Please, if any of these side effects persist, check with your doctor.
The fifth one is:
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Choosing Fenugreek Supplements For Your Cancer
The reason there is no easy way to answer the question When should I avoid Fenugreek for Cancer is because It Depends!. Just like the same treatment does not work for every cancer patient, based on your individual context the Fenugreek may be harmful or safe. Along with which cancer and associated genetics the ongoing treatments, supplements, lifestyle habits, BMI and allergies are all factors deciding if Fenugreek should be avoided or not and why.
Fenugreek: An Herb With Impressive Health Benefits
Fenugreek is an herb long used in alternative medicine. Its a common ingredient in Indian dishes and often taken as a supplement.
This herb may have numerous health benefits.
This article explains everything you need to know about fenugreek, including its benefits, side effects, and uses.
For thousands of years, fenugreek has been used in alternative and Chinese medicine to treat skin conditions and many other diseases .
Recently, it has become a common household spice and thickening agent. It can also be found in products, such as soap and shampoo.
Fenugreek seeds and powder are also used in many Indian dishes for their nutritional profile and slightly sweet, nutty taste.
- Iron: 20% of the Daily Value
- Manganese: 7% of the DV
- Magnesium: 5% of the DV
Fenugreek seeds have a healthy nutritional profile, containing a good amount of fiber and minerals, including iron and magnesium.
While prescription drugs are commonly used to boost breastmilk production, research suggests that fenugreek may be a safe, natural alternative.
One 14-day study in 77 new mothers found that drinking herbal tea with fenugreek seeds increased breast milk production, which helped babies gain more weight .
Another study split 66 mothers into three groups. One received fenugreek tea, the second a placebo, and the third nothing.
The volume of pumped breast milk increased from around 1.15 ounces in the control and placebo groups to 2.47 ounces in the fenugreek group .
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Effect Of Fse On Cell Apoptosis
The results indicated the changes in the percentage of early and late apoptotic cells in a dose-dependent manner. As depicted in Figure 7A, the 13.3% cells were found to be necrotic but no apoptosis in the MCF-7 cells exposed to FSE 40, whereas 11.6% necrotic cells, 8.81% early and 16.1% late apoptotic cells were estimated in FSE 80 treated cells. It was found only ~5% necrosis in the cells exposed to FSE 100 and FSE 150. Whereas an increase in apoptosis, as 12.5 and 12.8% late and 20.4, and 20.0% early apoptotic cells were recorded, respectively . As shown in Figure 7B, the necrotic death was found to be 8.68, 16.5, and 10.8% in the SK-BR3 cells exposed to FSE 80, 100, and 150, respectively. Besides, the significant changes were also observed in the stages of apoptosis in a dose-dependent manner as 4.2, 8.84, and 13.2% early and 20.2, 34.3, and 48.3% late apoptosis were explored, correspondingly in the cells treated with FSE 80, 100, and 150.
Invasiveness Migration And Metastasis
Cancer cell invasion is one of the major challenges to achieve relapse-free and sustainable patient survival . Tumor invasion is characterized by cell motility, migration and degradation of the extracellular matrix with concomitant intravasation into blood and/or lymphatic vessels and metastasis of distant organs . Although, only very few migrant cells initiate de novo tumor growth in a new organ , metastasis is responsible for most of the cancer-related deaths. Invasion is regulated by several factors , such as the PTEN/PI3K and MAPK/ERK pathways as well as increased MMP expression and activity. The effect of the extracts and major compounds on the major metalloproteinases associated with cancer invasiveness can be found in Figure 8.
Figure 8. Extracts from North African plants and major compounds decrease cancer migration by inactivating metalloproteinases. Diosgenin decreases the activity of MMP-2, -7, and 9. Trigonelline decreases the activity of MMP-7.
Nigella Sativa and Thymoquinone
A supercritical carbon dioxide extract inhibited colony formation in a dose-dependent manner, decreased cell motility and cell invasion . Thymoquinone inhibited migration of both MCF-7 and MDA-MB-231 cells and invasion of MDA-MB-231 cells .
Diosgenin and Trigonelline
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Are Fenugreek Supplements Safe For Healthy Individuals With Alk Mutation Associated Genetic Risk
ALK is one of the genes available in panels for cancer risk testing. ALK mutation causes biochemical pathways/processes like JAK-STAT Signaling, Stem Cell Signaling, Angiogenesis and Growth Factor Signaling to get impacted. These pathways are direct or indirect drivers of cancer molecular endpoints. Consider taking Fenugreek supplement when the genetic panel identifies mutations in ALK for the Central Nervous System. Fenugreek impacts pathways/processes like JAK-STAT Signaling and Growth Factor Signaling and creates a supportive effect in those with ALK mutation and related conditions.
* Other Factors are also included like BMI, Lifestyle Habits, Treatments
How Long Does Fenugreek Take To Work For Breast Enlargement
Simply so, What vitamins help breast growth?
Vitamin C helps with breast enlargement by promoting healthy skin production. Since Vitamin C is known to be responsible for collagen production with keeping the skin toned and firm, this helps keep your breasts perky.
Is it possible to increase breast size? There are many ways a woman can naturally enhance her breast size. Exercising, eating the right food and a few changes in your lifestyle may get you the desired results. Exercising regularly and in the right way may help you in getting bigger breasts.
27 Related Questions Answers Found
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Effect Fse On Cell Cycle Analysis
The distribution of cell cycle analyses of the flow cytometry data revealed the continuous shift of cell cycle arrest in a dose-dependent manner in both of the breast cancer cells . The exposure of MCF-7 cells to the doses of IC10 and IC25 showed the accumulation of the proportion of cells in S-phase from 31.2% ± 1.7% to 44.3% ± 2.19% and 54.6% ± 1.29%, respectively. Whereas, the accumulation of the percentage of SK-BR3 cells exposed to the similar IC doses of FSE was changed in S-phase from 41.82% ± 2.18% to 64.267% ± 2.23% and 75.1% ± 2.67%, correspondingly. The robust cell cycle arrest was observed in G2/M and > G2 phases, as the cells were treated with IC35 and IC50. The proportion of the cells was accumulated in G2/M and > G2 phase from 22.4%±1.4% and 0.0 to 77.23%± 2.75% and 23.1%± 2.89% exposed to FSE 100, whereas it was found to be 70.33%±3.59% and 30.83%±2.74% in the cells treated with FSE 150, respectively. However, the cell cycle was arrested to 29.5%±1.49% and 10.2%±0.87% and 38.63%±1.06% and 6.5%±0.67% cells in G2/M & > G2 phase from 23.73%±1.48% and 0.0% exposed to IC35 and IC50 in SK-BR3 cells. These results suggested that FSE inhibited cellular proliferation via S, G2/M, as well as > G2 phase cell cycle arrest in a dose-dependent manner.