Choosing Fenugreek Supplements For Your Cancer
The reason there is no easy way to answer the question When should I avoid Fenugreek for Cancer is because It Depends!. Just like the same treatment does not work for every cancer patient, based on your individual context the Fenugreek may be harmful or safe. Along with which cancer and associated genetics the ongoing treatments, supplements, lifestyle habits, BMI and allergies are all factors deciding if Fenugreek should be avoided or not and why.
I Thought I Had Let Myself Down
There are so many scare-mongering articles about how dairy or even asparagus causes breast cancer. You get pulled in, and if you don’t have the right information then how do you know any different? My cancer was hereditary, but for the many whose isn’t, it’s hard to accept that there isn’t an obvious cause.
What Is The Risk Of Breast Cancer When Taking Hrt
Every woman in the UK has a 1 in 7 chance of developing breast cancer, whether they take HRT or not. There are several factors that increase your risk, including getting older, being overweight, drinking alcohol, smoking, not exercising regularly, and having family members who had breast cancer at a young age.
Until you reach the age of 51, you might be surprised to discover that you have absolutely no increased risk of getting breast cancer when you take HRT. This is because you are simply replacing the hormones that your body would have been producing until the average age of menopause.
There is no good evidence that taking any type of HRT at any age significantly increases the risk of developing breast cancer. Studies have also shown that women taking HRT actually have a lower risk of dying from breast cancer as well as a lower risk of developing diseases such as heart disease, osteoporosis, diabetes and dementia.
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Are Fenugreek Supplements Safe For Healthy Individuals With Alk Mutation Associated Genetic Risk
ALK is one of the genes available in panels for cancer risk testing. ALK mutation causes biochemical pathways/processes like JAK-STAT Signaling, Stem Cell Signaling, Angiogenesis and Growth Factor Signaling to get impacted. These pathways are direct or indirect drivers of cancer molecular endpoints. Consider taking Fenugreek supplement when the genetic panel identifies mutations in ALK for the Central Nervous System. Fenugreek impacts pathways/processes like JAK-STAT Signaling and Growth Factor Signaling and creates a supportive effect in those with ALK mutation and related conditions.
* Other Factors are also included like BMI, Lifestyle Habits, Treatments
Alternative And Complementary Therapies
In addition to medical interventions, you may want to consider complementary therapies, particularly to help manage symptoms as well as side effects from treatment.
Acupuncture, massage, meditation, mindfulness, and visualization may help reduce stress and anxiety, relieve pain, and improve mood.
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Is Family History Of Breast Cancer Important
Yes. While only 5-10% of all women diagnosed with breast cancer have a family history, it is important to know your family’s history of cancer, if any, both on your mother’s side and your father’s side. Women with at least one close family relative should start a screening program with a breast specialist when they are ten years younger than their relative’s age at diagnosis, but usually not before 20 years old.
General Considerations For Screening
The goal of screening for cancer is to detect preclinical disease in healthy, asymptomatic patients to prevent adverse outcomes, improve survival, and avoid the need for more intensive treatments. Screening tests have both benefits and adverse consequences .
Breast self-examination, breast self-awareness, clinical breast examination, and mammography all have been used alone or in combination to screen for breast cancer. In general, more intensive screening detects more disease. Screening intensity can be increased by combining multiple screening methods, extending screening over a wider age range, or repeating the screening test more frequently. However, more frequent use of the same screening test typically is associated with diminishing returns and an increased rate of screening-related harms. Determining the appropriate combination of screening methods, the age to start screening, the age to stop screening, and how frequently to repeat the screening tests require finding the appropriate balance of benefits and harms. Determining this balance can be difficult because some issues, particularly the importance of harms, are subjective and valued differently from patient to patient. This balance can depend on other factors, particularly the characteristics of the screening tests in different populations and at different ages.
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Types Of Breast Cancer
There are several different types of breast cancer, which develop in different parts of the breast.
Breast cancer is often divided into either:
- non-invasive breast cancer found in the ducts of the breast which has not spread into the breast tissue surrounding the ducts. Non-invasive breast cancer is usually found during a mammogram and rarely shows as a breast lump.
- invasive breast cancer where the cancer cells have spread through the lining of the ducts into the surrounding breast tissue. This is the most common type of breast cancer.
Other, less common types of breast cancer include:
- invasive lobular breast cancer
- inflammatory breast cancer
It’s possible for breast cancer to spread to other parts of the body, usually through the blood or the axillary lymph nodes. These are small lymphatic glands that filter bacteria and cells from the mammary gland.
If this happens, it’s known as secondary, or metastatic, breast cancer.
What Is A Normal Breast
No breast is typical. What is normal for you may not be normal for another woman. Most women say their breasts feel lumpy or uneven. The way your breasts look and feel can be affected by getting your period, having children, losing or gaining weight, and taking certain medications. Breasts also tend to change as you age. For more information, see the National Cancer Institutes Breast Changes and Conditions.external icon
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What Are The Signs Of Breast Cancer Recurrence
Breast cancer can return to the original site or it can return and spread to other areas of the body, which is called distant recurrence or metastasis. Local recurrence is generally discovered during routine mammograms or when the patient notices a physical change. Most often, women experience symptoms such as weight loss, bone pain, or shortness of breath. There can often be nodules on or under the skin of the chest wall, or a new area of thickening near the scar left from the mastectomy. If the cancer recurrence in the regional area, such as the lymph nodes, you may notice swelling or a lump under your arm, in your neck, or near the collarbone.
Depending on what the symptoms are, your doctor may want to do a tissue biopsy, blood tests such as a tumor marker, or other imaging tests like a CT scan or bone scan. If the cancer is determined to be metastatic breast cancer, this means that it has spread to other areas such as the lungs, bones, or brain. Its still called breast cancer, even though it has spread.
Effect Fse On Cell Cycle Analysis
The distribution of cell cycle analyses of the flow cytometry data revealed the continuous shift of cell cycle arrest in a dose-dependent manner in both of the breast cancer cells . The exposure of MCF-7 cells to the doses of IC10 and IC25 showed the accumulation of the proportion of cells in S-phase from 31.2% ± 1.7% to 44.3% ± 2.19% and 54.6% ± 1.29%, respectively. Whereas, the accumulation of the percentage of SK-BR3 cells exposed to the similar IC doses of FSE was changed in S-phase from 41.82% ± 2.18% to 64.267% ± 2.23% and 75.1% ± 2.67%, correspondingly. The robust cell cycle arrest was observed in G2/M and > G2 phases, as the cells were treated with IC35 and IC50. The proportion of the cells was accumulated in G2/M and > G2 phase from 22.4%±1.4% and 0.0 to 77.23%± 2.75% and 23.1%± 2.89% exposed to FSE 100, whereas it was found to be 70.33%±3.59% and 30.83%±2.74% in the cells treated with FSE 150, respectively. However, the cell cycle was arrested to 29.5%±1.49% and 10.2%±0.87% and 38.63%±1.06% and 6.5%±0.67% cells in G2/M & > G2 phase from 23.73%±1.48% and 0.0% exposed to IC35 and IC50 in SK-BR3 cells. These results suggested that FSE inhibited cellular proliferation via S, G2/M, as well as > G2 phase cell cycle arrest in a dose-dependent manner.
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Family History And Inherited Genes
Some people have a higher risk of developing breast cancer than the general population because other members of their family have had particular cancers. This is called a family history of cancer.
Having a mother, sister or daughter diagnosed with breast cancer increases the risk of breast cancer. This risk is higher when more close relatives have breast cancer, or if a relative developed breast cancer under the age of 50. But most women who have a close relative with breast cancer will never develop it.
Some people have an increased risk of breast cancer because they have an inherited gene fault. We know about several gene faults that can increase breast cancer risk and there are tests for some of them. Having one of these faulty genes means that you are more likely to get breast cancer than someone who doesnt. But it is not a certainty.
Two of these faulty genes are known as BRCA1 and BRCA2. These are not common. Only about 2 out of every hundred of breast cancers are related to a change in the BRCA1 or BRCA2 genes.
Ionising radiation includes tests such as x-rays and CT scans and treatment such as radiotherapy.
Is Jeera Water Good For Weight Loss
Jeera water is said to aid digestion and improve bowel movement. It secretes enzymes, which help in breaking down sugars, fats and carbohydrates that keep the gut healthy. A good digestive system is the key to losing weight effectively. Better digestion further helps in improving metabolic rate, leading to weight loss.
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What Is A Young Adult Cancer
There is no strict definition of what separates childhood cancers from cancers in young adults, or when exactly a person is no longer a young adult. But for statistics purposes, cancers in young adults are often thought of as those that start between the ages of 20 and 39.
Cancer is not common in young adults, but a wide variety of cancer types can occur in this age group, and treating these cancers can be challenging.
Most cancers occur in older adults. The most common cancers in older people are cancers of the skin, lung, colon and rectum, breast , and prostate . Many cancers in older adults are linked to lifestyle-related risk factors or to other environmental factors. A small portion are strongly influenced by changes in a persons genes that they inherit from their parents.
Cancers that start in children or in teens are much less common. The types of cancers that develop in children and teens are often different from the types that develop in adults. Childhood cancers are often the result of gene changes that take place very early in life, sometimes even before birth. Unlike many cancers in adults, cancers in children and teens are not strongly linked to lifestyle or environmental risk factors.
The types of cancers that occur in young adults are a mix of many of the types that can develop in children, teens, and older adults.
What Happens If My Test Is Positive For Hereditary Breast Cancer Risk
If testing confirms you are at risk, your care provider can work with you on a plan to safeguard your health, which could include:
- High-risk evaluation and monitoring
- Screening schedules, including digital mammography and clinical breast exams
- Hormonal therapy medications designed to prevent the development of breast cancer
Preventive surgery, such as mastectomy with breast reconstruction, is necessary only for patients at very high risk for aggressive breast cancer.
A comprehensive breast center offers a safe and supportive environment where you can ask questions and get the best answers for you, Ninan says. Every patients decision about how to handle their risk of developing breast cancer is managed with sensitivity and an understanding about the complexity of these decisions.
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Fse Induced Cytotoxicity In Mcf
The cell viability was evaluated on MCF-7 and SK-BR3 breast cancer cells by the cell cytotoxicity assay following 48 hours of treatment with various concentrations of FSE. As depicted in Figure 3, both of the cell lines responded to the anti-proliferative and cytotoxic effects of FSE in a dose-dependent manner. It induced the cell proliferation within the range of 110 µg/mL, whereas started the growth inhibition at 25 µg/mL of FSE in MCF7 cells, and IC50 was observed at 150 µg/mL . The induction of cell proliferation was recorded at only 12 µg/mL in SK-BR3 cells, though it initiated the cytotoxic effect of cell death at 5 µg/mL. The SKBR3 cell showed potent cytotoxic activity as the IC50 was measured at 40 µg/mL . This primary screening of both of the cells helped us to select the four different doses for each cell line for further studies that showed the viability of the cells from 90 to 50%. The four doses that showed IC10, IC25, IC35, IC50 for the MCF-7 and SK-BR3 cells were selected and designated as follows: 40 , 80 , 100 and 150 µg/mL and 10 , 20 , 30 and 40 µg/mL , respectively.
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Figure 3 The analysis of cell viability by cell cytotoxicity assay. Notes: MCF-7 and SKBR3 cells were treated with a range of FSE doses for 48 hours in 96 well plates, and the percentage of cell viability was measured by cell cytotoxicity assay kit. Data represented mean percentages of viable cells ± SEM of three independent experiments. |
Where Does Breast Cancer Recur
Breast cancer recurrence can be categorized by where in the body it occurs when it returns. These categories include:
- Local recurrence This type of recurrence describes breast cancer that develops in or near the same area where it originally developed, such as scar tissue, the chest wall or other nearby tissue.
- Regional recurrence Breast cancer that returns in a nearby region, such as the lymph nodes in the armpit or collar bone, is known as a regional recurrence.
- Distant recurrence Also called metastatic recurrence, this type of recurrence describes breast cancer that returns in a distant area of the body, such as the bones, lungs or liver.
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Prognosis Of Breast Cancer
Prognosis depends on the stage of breast cancer and the general health of any given individual. But broadly, rates of death from breast cancer have been decreasing. The majority of women survive this cancer. Overall, 90 percent of women will survive at least five years after being diagnosed with breast cancer. As of January 2020, more than 3.5 million women in the United States have a history with breast cancer.
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Cancers Of The Female Genital Tract
Cervical cancer tends to occur in midlife. Most often it is found in women younger than 50. It rarely occurs in women younger than 20. Most cervical cancers can be found early, or even prevented, with screening tests. Vaccines against HPV, the virus linked to most cervical cancers, can also help prevent it. The most common symptom of cervical cancer is abnormal vaginal bleeding.
Overall, ovarian cancer is much more common in older women than in women younger than 40. But some less common types of ovarian cancers, known as germ cell tumors, are more common in teens and young women than in older women. Early ovarian cancer usually does not cause symptoms, but some women might feel full quickly when eating or they might have abnormal bloating, belly pain, or urinary symptoms. Women who have any of these symptoms lasting more than a few weeks should see their doctor.
For more information, see Cervical Cancer and Ovarian Cancer.
Signs And Symptoms Of Inflammatory Breast Cancer
Inflammatory breast cancer causes a number of signs and symptoms, most of which develop quickly , including:
- Swelling of the skin of the breast
- Redness involving more than one-third of the breast
- Pitting or thickening of the skin of the breast so that it may look and feel like an orange peel
- A retracted or inverted nipple
- One breast looking larger than the other because of swelling
- One breast feeling warmer and heavier than the other
- A breast that may be tender, painful or itchy
- Swelling of the lymph nodes under the arms or near the collarbone
If you have any of these symptoms, it does not mean that you have IBC, but you should see a doctor right away. Tenderness, redness, warmth, and itching are also common symptoms of a breast infection or inflammation, such as mastitis if youre pregnant or breastfeeding. Because these problems are much more common than IBC, your doctor might suspect infection at first as a cause and treat you with antibiotics.
Treatment with antibiotics may be a good first step, but if your symptoms dont get better in 7 to 10 days, more tests need to be done to look for cancer. Let your doctor know if it doesn’t help, especially if the symptoms get worse or the affected area gets larger. The possibility of IBC should be considered more strongly if you have these symptoms and are not pregnant or breastfeeding, or have been through menopause. Ask to see a specialist if youre concerned.
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