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How Long Do You Live With Triple Negative Breast Cancer

Will I Die Of Breast Cancer

HOW I WAS DIAGNOSED WITH TRIPLE NEGATIVE BREAST CANCER

This is a difficult question to answer early in your cancer care but it is still worth asking. Many people just diagnosed with cancer have no idea how much of a risk to their life their unique situation poses. Most breast cancers carry a low risk of recurrence, especially early-stage cancers. The answer is usually reassuring.

Variable And Outcome Definitions

The database was used to gather information regarding patient demographics , cancer stage , tumour characteristics , type of therapy , dosing and administration details of chemotherapy, and pathologic and clinical outcomes. Clinical outcomes included local recurrence, distant recurrence, breast cancer-related death, non-breast cancer-related death, and death from unspecified cause. These clinical end points were translated to the outcomes of interest on the basis of the STEEP criteria. Recurrence-free interval was measured from the date of diagnosis of primary cancer to the date of first invasive ipsilateral breast tumour recurrence, local or regional invasive recurrence, distant recurrence, or death documented because of breast cancer. Recurrence-free survival was measured from the date of diagnosis of primary cancer to the date of the first invasive ipsilateral breast tumour recurrence, local or regional invasive recurrence, distant recurrence, or death from any cause. Distant relapse-free survival was measured from the date of diagnosis of primary cancer to the date of first distant recurrence or death from any cause . Patients were censored at the date of their last follow-up for those who did not have an event.

Eight Important Updates For Triple

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Today is Triple-Negative Breast Cancer Awareness Day.

Triple-negative breast cancer accounts for approximately 15% of all breast cancer cases.

The aggressive subtype is so named because the estrogen, progestin and HER2 receptors are not expressed. Most approved therapies target these receptors, making triple-negative disease difficult to treat and leading to poor prognosis.

Five-year survival rates are 91% for those with localized disease, 65% for those with regional disease and 11% for those with distant disease.

This breast cancer subtype is more common among women aged younger than 40 years, black women and those with BRCA1 mutations.

In conjunction with Triple-Negative Breast Cancer Awareness Day, Healio and HemOnc Today present the following updates in research and treatment.

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Who Is Most Likely To Have Tnbc

Triple negative breast cancer appears more frequently in women age 40 and younger than in older women. Black and Latina women are more likely to develop TNBC than white women. Women who have the gene change BRCA1 are more likely to develop TNBC than other women. When the BRCA1 gene mutates, it stops preventing cancer and appears to make your bodys cells more vulnerable to cancer.

Survival For All Stages Of Breast Cancer

Triple Negative Breast Cancer Day

Generally for women with breast cancer in England:

  • Around 95 out of every 100 women survive their cancer for 1 year or more after diagnosis
  • Around 85 out of every 100 women will survive their cancer for 5 years or more after diagnosis
  • Around 75 out of every 100 women will survive their cancer for 10 years or more after diagnosis

Cancer survival by stage at diagnosis for England, 2019Office for National Statistics

These statistics are for net survival. Net survival estimates the number of people who survive their cancer rather than calculating the number of people diagnosed with cancer who are still alive. In other words, it is the survival of cancer patients after taking into account that some people would have died from other causes if they had not had cancer.

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Statistics Don’t Account For Late Recurrences

When comparing triple-negative breast cancer to positive tumors, it’s important to keep in mind late recurrences. Most statistics are presented as five-year survival rate, and in this setting, triple-negative breast cancer can look more ominous. But looking at longer periods of time, say 20 years following diagnosis, this may be different.

Emotional And Spiritual Care

End-of-life care also includes emotional, mental, and spiritual therapy. A personĂ¢s healthcare team may include social workers, counselors, mental health professionals, and religious or spiritual advisors.

According to the Anxiety and Depression Association of America, up to 40 percent of people with cancer experience serious mental distress. This may include anxiety, depression, panic attacks, and post-traumatic stress disorder .

Medications, therapy, religious or spiritual rituals, and support groups can help a person cope with mental health issues and stress during this difficult time.

Caregivers may also need help with stress, anxiety, and depression. The palliative care team can usually also provide support and advice to caregivers for their emotional needs.

The Breast Cancer Healthline app provides people with access to an online breast cancer community, where users can connect with others and gain advice and support through group discussions.

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What Is The Treatment For Triple Negative Breast Cancer

Healthcare providers and researchers are making significant progress on TNBC treatments. Recent clinical trials are testing new combinations of drugs and new approaches to existing treatments. Some existing treatments are:

  • Chemotherapy: Providers might combine chemotherapy and surgery, with chemotherapy being used to shrink your tumor before surgery or after surgery to kill cancer cells throughout your body.
  • Surgery: This could be a lumpectomy to remove an individual lump, or a mastectomy to remove an entire breast. Providers then perform a sentinel node biopsy or axillary node surgery to look for signs your breast cancer has spread to your lymph nodes.
  • Radiation therapy: Post-surgery radiation therapy helps reduce the chances your cancer will return or recur.
  • Immunotherapy: This treatment stimulates your immune system to produce more cancer-fighting cells or help healthy cells identify and attack cancer cells. Immunotherapy can be added to chemotherapy to before surgery to shrink the tumor. You might also receive immunotherapy for about a year after your surgery and post-surgery radiation therapy.

What Tumor Factors Threaten My Life More

Medical update: Triple-negative breast cancer with Rita Nanda, MD

There are important tumor biology factors not well reflected in survival statistics by breast cancer stage. Below we list a few important factors that carry a higher risk to life beyond just the stage of cancer. You must ask your surgeon or medical oncologist to explain your receptor status and give you a copy of your biopsy pathology report.

Triple Negative Receptor breast cancer

Triple negative breast cancer is considered a more aggressive breast cancer. Invariably it does require chemotherapy. If you have triple negative breast cancer the risk of dying is higher than the standard statistics usually quoted for a particular stage of breast cancer . Learn more about Triple Negative Breast Cancer with our video lesson

HER2-Positive breast cancer

HER2-positive breast cancers are also more aggressive tumors. But the good news is that we now have incredibly effective, targeted chemotherapy and immunotherapy for HER2-positive cancers. Our video lesson covers HER2-Positive Breast Cancer in more detail .

Breast Cancer at a Young Age

Women younger than 40 have a higher chance of being diagnosed with a more advanced stage breast cancer. Also, the specific cancer type younger women develop has a higher chance of being more aggressive . As a result, age is a relative risk factor for survival.

Untreated breast cancer

Teaching everyone to be an expert in their own breast cancer care.

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What Is The Survival Rate For Triple Negative Breast Cancer

Survival rates are a way to discuss the prognosis and outlook of a cancer diagnosis. The number most frequently mentioned is 5-year survival. Many patients live much longer, and some die earlier from causes other than breast cancer. With a constant change and improvement in therapies, these numbers also change. Current 5-year survival statistics are based on patients who were diagnosed at least 5 years ago and may have received different therapies than are available today.

Below are the statistics from the National Cancer Institute’s SEER database for survival of all patients with breast cancer, by tumor stage:

Stage
IV22%

What Is The Prognosis Of Liver Cancer What Are The Survival Rates For Liver Cancer

The prognosis for liver cancer depends on multiple factors such as the size of the liver cancer, the number of lesions, the presence of spread beyond the liver, the health of the surrounding liver tissue, and the general health of the patient. Life expectancy depends on many factors that impact whether a cancer is curable.

The American Cancer Society states the overall 5-year survival rate for all stages of liver cancer is 15%. One of the reasons for this low survival rate is that many people with liver cancer also have other underlying medical conditions such as cirrhosis. However, the 5-year survival rate can vary depending on how much the liver cancer has spread.

If the liver cancer is localized , the 5-year survival rate is 28%. If the liver cancer is regional , the 5-year survival rate is 7%. Once the liver cancer is distant , the survival time is as low as 2 years.

Survival rate can also be affected by the available treatments. Liver cancers that can be surgically removed have an improved 5-year survival rate of over 50%. When caught in the earliest stages, and the liver is transplanted, the 5-year survival rate can be as high as 70%.

Primary liver cancer deaths are usually from liver failure, bleeding, or advanced cancer.

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How Is Invasive Ductal Carcinoma Diagnosed

Same Day Results

At the Johns Hopkins Breast Center, we know how quickly patients want results from a biopsy or scan if there is a suspicion of breast cancer. We follow strict guidelines for biopsies and pathology reports. Most of our patients will receive the probability of cancer immediately following their biopsy procedure and a pathology confirmation within 24 hours.

Learn more about the steps of diagnosis, including:

  • Digital mammography
  • Biologic targeted therapy

Survival Rates For Metastatic Breast Cancer

Treatment Options

According to the American Cancer Society , the 5-year survival rate after diagnosis for people with stage 4 breast cancer is 28 percent. This percentage is considerably lower than earlier stages. For all stages, the overall 5-year survival rate is 90 percent.

Because survival rates are higher in the early stages of breast cancer, early diagnosis and treatment is crucial. But remember: The right treatment for stage 4 breast cancer can improve quality of life and longevity.

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What Is Triple Negative Breast Cancer

Triple negative breast cancer is a rare cancer that affects about 13 in 100,000 women each year. It represents about 15 % of all invasive breast cancers. Triple negative breast cancer is one of three types of breast cancer. It is called as triple negative because it doesnt have three markers associated with other types of breast cancer, which is important for prognosis and treatment. Its one of the more challenging breast cancers to treat. But researchers are making steady progress toward more effective treatments. Overall, 77% of women who have triple negative breast cancer are alive five years after diagnosis.

Symptoms Of Metastatic Breast Cancer

When metastatic breast cancer stops responding to treatment, the focus may shift to end-of-life care.

The symptoms of metastatic breast cancer are different to those of early-stage breast cancer. This is because the cancer has spread to other organs and is affecting other body systems, as well as the affected breast.

Most of the time, metastatic breast cancer affects the bones, lungs, brain, or liver.

Having one or more of the following symptoms does not mean that a person has metastatic breast cancer. However, anyone who experiences these symptoms should see a doctor for an evaluation.

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Do I Need Genetic Counseling And Testing

Your doctor may recommend that you see a genetic counselor. Thats someone who talks to you about any history of cancer in your family to find out if you have a higher risk for getting breast cancer. For example, people of Ashkenazi Jewish heritage have a higher risk of inherited genetic changes that may cause breast cancers, including triple-negative breast cancer. The counselor may recommend that you get a genetic test.

If you have a higher risk of getting breast cancer, your doctor may talk about ways to manage your risk. You may also have a higher risk of getting other cancers such as ovarian cancer, and your family may have a higher risk. Thats something you would talk with the genetic counselor about.

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Survival Rates For Triple

Living With Triple Negative Breast Cancer | Health Now

Triple-negative breast cancer is considered an aggressive cancer because it grows quickly, is more likely to have spread at the time its found and is more likely to come back after treatment than other types of breast cancer. The outlook is generally not as good as it is for other types of breast cancer.

Survival rates can give you an idea of what percentage of people with the same type and stage of cancer are still alive a certain amount of time after they were diagnosed. They cant tell you how long you will live, but they may help give you a better understanding of how likely it is that your treatment will be successful.

Keep in mind that survival rates are estimates and are often based on previous outcomes of large numbers of people who had a specific cancer, but they cant predict what will happen in any particular persons case. These statistics can be confusing and may lead you to have more questions. Talk with your doctor about how these numbers may apply to you, as he or she is familiar with your situation.

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How Life Expectancy And Relapse Differ From Positive Tumors

Questions about the survival rate and recurrence rate are very common when someone is diagnosed with triple-negative breast cancer . While prognosis is, on average, poorer than with hormone receptor or human epidermal growth factor receptor 2 positive tumors, triple-negative breast cancer is a very heterogeneous disease. On a positive note, and unlike hormone-positive tumors that commonly recur late , late recurrence is less common with triple-negative tumors. The recent approval of immunotherapy only for triple-negative disease is also optimistic.

We will look at factors that may affect survival or recurrence as well as the statistical rates of both. We will also look at life expectancy with stage 4 triple-negative breast cancers and recent case reports of a few long-time survivors.

Survival Rate For Patients With Triple

Triple-negative breast cancer is considered aggressive, or fast-growing, but it is treatable. Survival depends on factors such as how advanced the cancer was at diagnosis, your overall health, and your response to treatment.

When assessing survival, researchers use a 5-year marker to make predictions about if cancer will reoccur.

According to the American Cancer Society, if any type of breast cancer is found to be stage 1, the 5-year survival rate is nearly 100%. Stage 2 breast cancer survival is about 93%, stage 3 is 72%, and metastasized or grade 4 breast cancer has about a 22% chance of survival. Keep in mind most triple-negative breast cancers are stage 3 when found.

Its important to note that the survival rates may be higher than this data suggests because new treatments are becoming available through clinical research.

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Coping With Your Prognosis

Even if your healthcare team has told you that your prognosis is very good, its normal to feel worried sometimes about how long youll live. Fear of recurrence or cancer progression is extremely common after a diagnosis.

If youre dealing with anxiety or overwhelmed about your prognosis, youre not alone, and were here for you. Visit our page on coping with a new breast cancer diagnosis for information and tips on navigating different emotions and finding support.

Survival Rate By Stage

What Is Triple

Breast cancer stage describes how far cancer has spread in your body. Different stages of breast cancer have different survival rates.

The SEER database does not use the American Joint Committee on Cancer TNM system for cancer stages that you may see on your pathology report. Instead, the SEER database uses stages known as localized, regional, and distant:

  • Localized means there is no evidence that cancer has spread beyond the breast.
  • Regional means that cancer was found in nearby lymph nodes or structures outside the breast.
  • Distant means the cancer has traveled to remote parts of the body such as bones, liver, or lungs.

Here are the SEER relative 5-year breast cancer survival rates, from the American Cancer Society website:

SEER stage

*These rates are based on women who were diagnosed between 2009 and 2015.

Its important to know that the survival rate for your type of breast cancer may be different than whats represented in this chart. Here are some reasons why:

  • The numbers in this chart represent women diagnosed and treated at least 5 years ago. As treatments improve, survival rate numbers can change.
  • The numbers you see here do not factor in certain cancer characteristics such as grade, hormone-receptor status, or HER2 status.
  • These numbers also dont consider how well a cancer treatment may be working in your body.

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