What Tests Detect Her2
All patients with invasive breast cancer should have their tumor cells tested for HER2.
There are four tests for HER2. Discuss the interpretation of the tests with your health care team. Health care professionals may use either immunohistochemistry to identify the HER2 protein or in-situ hybridization testing to look for the gene.
IHC test: This tests shows if there is too much HER2 protein in the cancer cells and is graded 0 to 3.
FISH test: This test evaluates if there are too many copies of the HER2 gene in the cancer cells. This test is either positive or negative.
SPoT-Light HER2 CISH test: This test also evaluates if there are too many copies of the HER2 gene in the cancer cells and is reported as positive or negative.
Inform HER2 Dual ISH test: This test also evaluates if there are too many copies of the HER2 gene in the cancer cells and is reported as positive or negative.
Limited Arm And Shoulder Movement
You might also have limited movement in your arm and shoulder after surgery. This is more common after ALND than SLNB. Your doctor may advise exercises to help keep you from having permanent problems .
Some women notice a rope-like structure that begins under the arm and can extend down toward the elbow. This is sometimes called axillary web syndrome or lymphatic cording. It is more common after ALND than SLNB. Symptoms may not appear for weeks or even months after surgery. It can cause pain and limit movement of the arm and shoulder. This often goes away without treatment, although some women may find physical therapy helpful.
You Have Enlarged Lymph Nodes Around Your Collarbone
Your armpits aren’t the only subtle place you might experience lymph node swelling due to breast cancer. According to the Mayo Clinic, the same issue can also occur above or below your collarbonesa location most people don’t even realize they have a set of lymph nodes in the first place. And for more red flags that aren’t always so obvious, check out 40 Subtle Signs Your Body Is Telling You Something’s Seriously Wrong.
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More Information About The Tnm Staging System
The T category describes the original tumor:
- TX means the tumor can’t be assessed.
- T0 means there isn’t any evidence of the primary tumor.
- Tis means the cancer is “in situ” .
- T1, T2, T3, T4: These numbers are based on the size of the tumor and the extent to which it has grown into neighboring breast tissue. The higher the T number, the larger the tumor and/or the more it may have grown into the breast tissue.
The N category describes whether or not the cancer has reached nearby lymph nodes:
- NX means the nearby lymph nodes can’t be assessed, for example, if they were previously removed.
- N0 means nearby lymph nodes do not contain cancer.
- N1, N2, N3: These numbers are based on the number of lymph nodes involved and how much cancer is found in them. The higher the N number, the greater the extent of the lymph node involvement.
The M category tells whether or not there is evidence that the cancer has traveled to other parts of the body:
- MX means metastasis can’t be assessed.
- M0 means there is no distant metastasis.
- M1 means that distant metastasis is present.
Can Blood Work Detect Breast Cancer
Yes. Cancerous tumors produce specific proteins that can be found in blood marker tests. Certain markers, such as CA 15.3, TRU-QUANT, and CA 27.29, typically indicate breast cancer may be present or if there is a cancer recurrence. Other markers, like CEA , can indicate that breast cancer is present and can also determine if it has traveled to other areas of the body. Doctors will often order blood tests before treatment and throughout the process to help diagnose the cancer, as well as to see how the cancer is responding to treatment methods. A blood test is a supplement to other breast cancer detection strategies, but it is not a foolproof method and should not be used in place of other cancer screenings.
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What Are Some General Signs And Symptoms Of Cancer
Most signs and symptoms are not caused by cancer but can be caused by other things. If you have any signs and symptoms that don’t go away or get worse, you should see a doctor to find out whats causing them. If cancer is not the cause, a doctor can help figure out what the cause is and treat it, if needed.
For instance, lymph nodes are part of the bodys immune system and help capture harmful substances in the body. Normal lymph nodes are tiny and can be hard to find. But when theres infection, inflammation, or cancer, the nodes can get larger. Those near the bodys surface can get big enough to feel with your fingers, and some can even be seen as swelling or a lump under the skin. One reason lymph nodes may swell is if cancer gets trapped there. So, if you have unusual swelling or a lump, you should see your doctor to figure out whats going on.
Here are some of the more common signs and symptoms that may be caused by cancer. However, any of these can be caused by other problems as well.
Sometimes, its possible to find cancer before you have symptoms. The American Cancer Society and other health groups recommend cancer-related check-ups and certain tests for people even though they have no symptoms. This helps find certain cancers early. You can find more information on early detection at the American Cancer Society Guidelines for the Early Detection of Cancer.
What Are Therapies For Her2
Your health care team needs to evaluate all therapy and provide guidance in response to all test results available and the specific circumstances of your cancer.
There are targeted therapies for HER2-positive breast cancers a number of drugs are available to target this protein:
- Trastuzumab : a monoclonal antibody given by itself or with chemotherapy to treat HER2-positive breast cancers
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Axillary Lymph Node Dissection
In this procedure, anywhere from about 10 to 40 lymph nodes are removed from the area under the arm and checked for cancer spread. ALND is usually done at the same time as a mastectomy or breast-conserving surgery , but it can be done in a second operation. ALND may be needed:
- If a previous SLNB has shown 3 or more of the underarm lymph nodes have cancer cells
- If swollen underarm or collarbone lymph nodes can be felt before surgery or seen on imaging tests and a FNA or core needle biopsy shows cancer
- If the cancer has grown large enough to extend outside the lymph node
- If the SLNB is positive for cancer cells after chemotherapy was given to shrink the tumor before surgery
What Do Lumps In My Breast Mean
Many conditions can cause lumps in the breast, including cancer. But most breast lumps are caused by other medical conditions. The two most common causes of breast lumps are fibrocystic breast condition and cysts. Fibrocystic condition causes noncancerous changes in the breast that can make them lumpy, tender, and sore. Cysts are small fluid-filled sacs that can develop in the breast.
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Symptoms Of Metastatic Breast Cancer
The symptoms of metastatic breast cancer may be different than those of early-stage breast cancer, but not always. Sometimes, there are no symptoms at all.
You should always speak with your doctor if you experience any new signs or symptoms, but here are some of the most common signs that breast cancer has spread:
- Bone pain or bone fractures due to tumor cells spreading to the bones or spinal cord
- Headaches or dizziness when cancer has spread to the brain
- Shortness of breath or chest pain, caused by lung cancer
- Jaundice or stomach swelling
The symptoms of breast cancer metastasis may also vary depending on where in the body the cancer has spread. For example:
- If the breast or chest wall is affected, symptoms may include pain, nipple discharge, or a lump or thickening in the breast or underarm.
- If the cancer has spread to bones, symptoms may include pain, fractures or decreased alertness due to high calcium levels.
- If the cancer has spread to the lungs, symptoms may include shortness of breath, difficulty breathing, coughing, chest pain or fatigue.
- If the cancer has spread to the liver, symptoms may include nausea, fatigue, swelling of the feet and hands or yellowing skin.
- If cancer has spread to the central nervous system, which includes the brain or spinal cord, symptoms may include pain, memory loss, headache, blurred or double vision, difficulty with and/or movement or seizures.
Signs Of Breast Cancer Recurrence
Despite initial treatment and success, breast cancer can sometimes come back. This is called recurrence. Recurrence happens when a small number of cells escape the initial treatment.
Symptoms of a recurrence in the same place as the first breast cancer are very similar to symptoms of the first breast cancer. They include:
- a new breast lump
- redness or swelling of the breast
- a new thickening near the mastectomy scar
If breast cancer comes back regionally, it means that the cancer has returned to the lymph nodes or near to the original cancer but not exactly the same place. The symptoms may be slightly different.
Symptoms of a regional recurrence may include:
- lumps in your lymph nodes or near the collarbone
- chest pain
- pain or loss of sensation in your arm or shoulder
- swelling in your arm on the same side as the original breast cancer
If youve had a mastectomy or other surgery related to breast cancer, you might get lumps or bumps caused by scar tissue in the reconstructed breast. This isnt cancer, but you should let your doctor know about them so they can be monitored.
As with any cancer, early detection and treatment are major factors in determining the outcome. Breast cancer is easily treated and usually curable when detected in the earliest of stages.
The best way to fight breast cancer is early detection. Talk with your doctor about when you should start scheduling regular mammograms.
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Stage 3 Breast Cancer
- Stage 3A:
- The cancer has spread to 49 axillary lymph nodes or has enlarged the internal mammary lymph nodes, and the primary tumor can be any size.
- Tumors are greater than 5 cm, and the cancer has spread to 13 axillary lymph nodes or any breastbone nodes.
What Can You Tell Me About The Alcohol And Breast Cancer Link
While countless studies support that wine is good for your heart health, you have to weigh these benefits against its link to cancer.
“There is good evidence that alcohol increases the risk for breast cancer,” Schnabel explained. “Specifically, women who drink at the rate of seven drinks per week have about a 20-percent increase in their risk for breast cancer.”
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How Do I Know If Medical Malpractice Is To Blame For My Misdiagnosis
If you think your breast cancer was misdiagnosed as a result of malpractice, consider scheduling a free consultation with a lawyer who specializes in medical malpractice cases. They should be able to determine if you are qualified and can give you more information about the process based on your individual case.
‘i Felt A Pea On My Ribs’
I had done monthly self-breast exams since I was in my early 20s. I felt a tiny hard little bump the size of a small pea. I could only feel it because it was over my rib at the bottom of my left breast. In retrospect, my bra may have hurt a little in that area before I found the lump. I have had many lumps, bumps, and cysts biopsied, but this pea was definitely different. I scheduled my annual mammogram along with a biopsy. I received the breast cancer diagnosis within a week, just shy of my 55th birthday. Turns out, there was another in the other breast that didnt show up on a mammogram. I also discovered I was a BRCA 1 mutation carrier. I needed aggressive chemo followed by a double mastectomy. Had I not done the exam that evening, everything would be quite different.
Cynthia Bailey, MD, president and CEO of Advanced Skin Care and Dermatology, Inc., Sebastopol, California
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Symptoms Of Angiosarcoma Of The Breast
Another rare form of breast cancer, angiosarcoma forms inside the lymph and blood vessels. Only a biopsy may definitively diagnose this type of cancer. Angiosarcoma can cause changes to the skin of your breast, such as the development of purple-colored nodules that resemble a bruise. These nodules, if bumped or scratched, may bleed. Over time, these discolored areas may expand, making your skin appear swollen in that area. You may or may not have breast lumps with angiosarcoma. If you also have lymphedema, which is swelling caused by a buildup of lymphatic fluid, angiosarcoma may occur in the affected arm. Cancer treatment sometimes damages the lymph vessels, which may lead to lymphedema.
What Are The Types Of Breast Cancer
The most common types of breast cancer are:
- Infiltrating ductal carcinoma. This cancer starts in the milk ducts of the breast. It then breaks through the wall of the duct and invades the surrounding tissue in the breast. This is the most common form of breast cancer, accounting for 80% of cases.
- Ductal carcinoma in situ is ductal carcinoma in its earliest stage, or precancerous . In situ refers to the fact that the cancer hasn’t spread beyond its point of origin. In this case, the disease is confined to the milk ducts and has not invaded nearby breast tissue. If untreated, ductal carcinoma in situ may become invasive cancer. It is almost always curable.
- Infiltrating lobular carcinoma. This cancer begins in the lobules of the breast where breast milk is produced, but has spread to surrounding tissues in the breast. It accounts for 10 to 15% of breast cancers. This cancer can be more difficult to diagnose with mammograms.
- Lobular carcinoma in situ is a marker for cancer that is only in the lobules of the breast. It isn’t a true cancer, but serves as a marker for the increased risk of developing breast cancer later, possibly in both or either breasts. Thus, it is important for women with lobular carcinoma in situ to have regular clinical breast exams and mammograms.
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Breast Cancer Types And Symptoms
There are several kinds of breast cancer. Many of them share symptoms.
Symptoms of ductal carcinoma
This is the most common type of breast cancer. It begins in your ducts. About 1 in 5 new breast cancers are ductal carcinoma in situ . This means you have cancer in the cells that line your ducts, but it hasnât spread into nearby tissue.
You may not notice any symptoms of ductal carcinoma. It can also cause a breast lump or bloody discharge.
Symptoms of lobular carcinoma
This kind begins in the glands that make milk, called lobules. Itâs the second most common type of breast cancer. Symptoms include:
- Fullness, thickening, or swelling in one area
- Nipples that are flat or point inward
Symptoms of invasive breast cancer
Breast cancer thatâs spread from where it began into the tissues around it is called invasive or infiltrating. You may notice:
- A lump in your breast or armpit. You might not be able to move it separately from your skin or move it at all.
- One breast that looks different from the other
- A rash or skin thatâs thick, red, or dimpled like an orange
- Skin sores
- Loss of appetite and weight loss
- Muscle weakness
Symptoms of triple-negative breast cancer
Breast cancer is called triple-negative if it doesnât have receptors for the hormones estrogen and progesterone and doesnât make a lot of a protein called HER2. This kind tends to grow and spread faster than other types, and doctors treat it differently.
Symptoms of male breast cancer
- A small, hard cyst
Testing For Proteins And Genes
The breast cancer cells will be tested for certain proteins called estrogen and progesterone receptors. If the cancer has these proteins, it’s called a hormone receptor positive breast cancer. The cells are also tested to see if the cancer makes too much of the HER2 protein. If it does, it’s called a HER2-positive cancer. These cancers are sometimes easier to treat. If the cancer doesn’t test positive for any of these proteins, it’s called a triple-negative breast cancer.
The cells might also be tested for certain genes, which can help decide if chemo might be helpful and how likely it is that the cancer will come back. Ask your doctor to explain the tests they plan to do, and what the results might mean.
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