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Is Collagen Bad For Breast Cancer

Breast Cancer Patients Should Avoid High

Understanding the Role of Collagen in Breast Cancer

When you’re told that you have breast cancer, it’s natural to wonder what may have caused the disease. But no one knows the exact causes of breast cancer. Doctors seldom know why one woman develops breast cancer and another doesn’t, and most women who have breast cancer will never be able to pinpoint an exact cause Among cancers, milk and dairy intake was inversely associated with colorectal cancer, bladder cancer, gastric cancer, and breast cancer, and not associated with risk of pancreatic cancer, ovarian. If you want to take a deep dive, Dr. Gonzalez masterfully dismantles the ketogenic diet for cancer in the lengthy article below. This is not a scientific rebuttal, quibbling over theories about Warburg, glycosis, cell respiration, and ATP, rather it is a thoughtful, well-reasoned reflection from a medical doctor who was in the trenches of nutritional cancer treatment for nearly three decades

Collagen As A Regulator For Tumor Associated Immune Infiltration

Collagen is not just a passive player during tumor progression. Recent experimental developments point to a far more complex role for these structure proteins. A variety of immune cells are present in cancers and many of these accumulate and migrate within regions of dense collagen .

Collagen regulates tumor associated immune infiltration. MMP-dependent collagen fragments can recruit monocytes and further promote them to differentiate into TAMs with the help of CSF-1. TAMs themselves secret factors responsible for tumor progression, including tumor angiogenesis. Meanwhile, they themselves can activate MMPs to degrade collagens

In addition, ECM stiffness could influence T cell activation via integrin-mediated adhesions assembly promotion and collagen-mediated activation of leukocyte-associated Ig-like receptors . LAIRs are highly expressed on most immune cells and can through their immunoreceptor tyrosine-based inhibition motifs inhibit immune cell activation . Although it is not clear whether LAIRs and integrins cooperate, activation of LAIRs is a plausible mechanism whereby high levels of deposited collagen lead to inhibition of an anti-tumor immune response.

Conventional Versus Hypofractionated Radiotherapy In Node Positive Breast Cancer

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Verified May 2016 by Mahmoud Ellithy, Ain Shams University. Recruitment status was: RecruitingFirst Posted : February 24, 2016Last Update Posted : June 1, 2016
  • Study Details

Breast cancer patients operated with modified radical mastectomy or breast conservative surgery will be randomized for either adjuvant conventional radiotherapy versus hypofractionated radiotherapy for chest wall and axilla or breast and axilla.

The patients will be recruited for one year and will be followed for 5 years by monitoring local recurrence, cosmetic outcomes, health economic perspectives, and arm lymph edema.

Condition or disease
Phase 3
Layout table for study information

Study Type :
Treatment
Official Title: Conventional Versus Hypofractionated Adjuvant Radiotherapy in Node Positive Breast Cancer. Phase III, Open Label, Randomized Trial. Comparing Local Control, Cosmetic Outcome, Arm Lymph Edema and Health Economic Perspectives
Study Start Date :

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Dcis Can Be Removed With Surgery

DCIS can often be removed via a lumpectomya surgery that spares the surrounding breast tissue.

When performing a lumpectomy, surgeons aim to remove all of the cancerous cells, plus a two-millimeter margin of healthy cells around the tumor. This helps ensure that the cancer is 100% removed, and lowers the risk of a recurrence.

Because some DCIS may never progress, some patients may also opt to skip surgery, adopting a watch-and-wait approach instead.

Cell Lines And Culture Conditions

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MDA-MB-231 were maintained in DMEM/F12 with 10% FBS and 1% Pen/Strep. BT549 cells were maintained in RPMI-1640 with 10% FBS and 1% Pen/Strep. MCF-10A cells were kind gifts from Michael W. Kilgore, University of Kentucky, Lexington, KY. MCF10A cells were cultured as previously described . Hs-578 T cells were kept as previously described . S1 and T42 cells are kind gifts from Dr. Mina J Bissell, and they were cultured as previously described . All the cells were tested for mycoplasma contamination every two months.

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When To Call The Healthcare Provider

  • Fever or chills
  • Signs of a breast infection or bleeding, such as severe breast swelling or bruising
  • Worsening or significant pain that is not relieved with medication
  • Signs of a wound infection including swelling, redness, warmth, bleeding, or foul-smelling drainage from the incision site
  • Reaction to any medication
  • Calf pain or chest pain
  • Trouble breathing

Collagen 1 Increases Kv101 And Orai1 Expressions And Potentiates Their Co

We have previously reported that Kv10.1 regulates cell migration in breast cancer cells by regulating basal calcium influx through Orai1 . Here we investigated the effect of collagen 1 on Kv10.1 and Orai1 expressions. The expression of Orai1 and Kv10.1 was increased by collagen 1 at both mRNA and protein levels in both cell lines .3). mRNA of Kv10.1 and Orai1 were increased by collagen 1 in MCF-7 , and in T47-D cells . Western blotting experiments showed also an increase in the expression of Kv10.1 and the glycosylated form of Orai1 in both cell lines . Similar results were observed by confocal fluorescence microscopy , p< 0.01 ). In order to show a possible functional interaction between Kv10.1 and Orai1, we analysed Kv10.1 and Orai1 staining and their colocalization at the plasma membrane of MCF-7 cells by fluorescence microscopy. As shown in Figure , Kv10.1 was co-localized with Orai1 only in the presence of collagen 1. Indeed, in the presence of collagen 1 the co-localization between these two channels reached 50% . These data demonstrated that collagen 1 not only induced an increase in Kv10.1 and Orai1 expression but also potentiated their co-localization and interaction leading to the regulation of basal Ca2+ influx in BC cells.

Collagen 1 increases Kv10.1 and Orai1 expression in both MCF-7 and T-47D cellsCollagen 1 promotes the co-localization of Kv10.1 and Orai 1 at plasma membrane in BC cells

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Both Kv101 And Orai1 Are Involved In Collagen

To determine whether Kv10.1 and Orai1 regulated Ca2+ entry induced by collagen 1, we performed Mn2+ quenching analysis. In both cell lines, siKv10.1 and siOrai1 inhibited the collagen dependent Ca2+ influx by 62 ± 0.22% , and 68 ± 4.02% respectively in MCF-7 cells, and by 60.89 ± 4.33% and 39.86 ± 6.67% respectively in T-47D cells when compared to the control siRNA . Moreover, no additive effect was observed when cells were simultaneously treated with both siRNAs . We also investigated the effect of anti-Kv10.1 and anti-Orai1 siRNAs on Ca2+ current recorded in MCF-7 cells . Patch clamp whole cell recordings showed a significant increase in Ca2+ inward current induced by collagen 1 at -100 mV . This increase was significantly reduced after the silencing of either of Orai1 or Kv10.1 . However, Orai1 or Kv10.1 silencing had no effect on Ca2+ current in plastic conditions . We also performed experiments on cell mortality and calcium entry using Kv10.1 pharmacological inhibitor. Treatment by astemizole led to an increase of cell mortality and a decrease of Ca2+ entry of cells seeded or not on collagen 1 . In non-treated cells, the rate of mortality decreased in the presence of collagen 1. However, when the cells were treated with astemizole, the rate of mortality increased and reached a level similar to that observed when the cells were seeded on plastic . Moreover, astemizole completely suppressed the collagen-dependent Ca2+ entry .

Can Shoulder Blade Pain Be A Symptom Of Breast Cancer

Patricia Keely on Collagen’s Role in Breast Cancer

Pain is not a common symptom of breast cancer. However, breast cancer that has metastasized can sometimes cause shoulder blade pain.

One of the most common locations for breast cancer metastasis is in the bones. Pain can be related to the cancer itself or fractures that happen when bones weaken.

Bladder, prostate, thyroid, uterus, lung, and kidney cancers can also spread to your bones. Lung and kidney cancers are also known to spread to the shoulder joint and shoulder blade.

It is also possible that pain near your right shoulder could be an indication that breast cancer has spread to your liver, because some of the nerve networks around the liver originate from the same nerves that attach near your right shoulder blade.

If youve had breast cancer in the past, and youre now experiencing shoulder pain, its a good idea to see a doctor about it as soon as possible. If it is a cancer relapse, treatment may help slow the cancers growth, relieve your symptoms, and protect your bones.

Yes. If youve had chemotherapy, radiation, or surgery, you may have pain around your shoulder blade because of those treatments.

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Foods That May Affect Breast Cancer Risk Health Live

The PSA levels in each of the 20 patients were all rising before they started the soy milk, suggesting they had relapsing or metastatic cancer growing inside of them. However, during a year drinking soy milk, 6 out of the 20 subjects got better, 2 got worse, and the remaining 12 remained unchanged, as you can see from 5:02 in my video So much so, that many of us have cautioned patients with higher risk of breast cancer to avoid daily alcohol consumption, says Kathleen Fairfield, MD, an internist at Maine Medical Center. 5) Women with high/frequent dairy consumption, are prone to breast cancer , and men are prone to prostate cancer. 6 ) Eating animal protein increases the blood levels of the growth hormone IGF-1, a proven predictor of cancer Results from 8 studies on consumption of whole milk and breast cancer risk were analyzed. The intake and range of whole milk of each study were shown in Table 1. The overall OR was 0.951 . This result indicated that high intakes of whole milk had no effect on breast cancer. 3.4 Yogur

What Are The Best Moisturizers For Your Skin While Youre Being Treated With Chemotherapy

Use only moisturizers with rich oils and water-binding ingredients that soak deeply into your skin. This keeps you from feeling greasy after applying them, and it keeps them from soiling your clothes.

Remember, moisturizers only work if they are applied right after you’ve had your skin in water. This is because they dont moisturize they trap the water that you just soaked up into your skin while your skin is wet. apply your moisturizer within the ‘Magic 3 Minutes’ after toweling dry. Dermatologist Dr. Cynthia Bailey

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Don’t Take Your Meds As Prescribed

You may shrug off pain medication because you heard it’s addictive or it makes you constipated, nauseous, or woozy. But skimping on your medicine isn’t smart.

Pain can sometimes interfere with your sleep, appetite, and ability to get around, Whiteson says. And that can make it harder for your body to heal. Ultimately, the goal is to get off medication, but not before you’re ready.

Collagen And Tumor Angiogenesis

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Angiogenesis, a specialized form of branching morphogenesis wherein endothelial cells detach themselves from the existing vasculature, invade surrounding tissues, and reorganize into patent tubules , is vital for tumor growth and metastasis. Tumor angiogenesis is characterized by the secretion of multiple pro-angiogenic factors to trigger the angiogenic switch resulting in the development of a structurally and functionally abnormal vasculature.

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How To Care For Your Scars And Minimize Their Appearance

Long before the incisions of a breast reduction turn into scars, you should follow your surgeons instructions for post-care.

Make sure you keep wearing chest bandages and your surgical bra for the first few days after surgery. Youll likely see your surgeon for a follow-up after this time. Theyll advise you on how to take care of your skin as it heals.

Once the incisions close, there are scar-minimizing techniques you may consider trying during the healing process . Your doctor may recommend more than one approach.

White House Mandates Pfizer Vaccines For Millions Of Citizens Before The Fda Clinical Or Safety Reviews Have Been Made Public

This advice is widely repeated on many reputable cancer websites. The American Cancer Society states that So far, no dietary supplements have been shown to clearly help lower the risk of breast cancer progressing or coming back, along with the advice to patients to speak to a member of their healthcare team if a patient is considering taking supplements.

I was never going to take anything that might reduce my chances of survival. However Im sure some cancer patients are desperate for the promise of a cure and will ignore this advice whilst they take every supplement recommended to them, said ORiordan.

Vitamin supplements, particularly multivitamins have had a rough couple of years with several studies questioning whether they have any positive effects on health at all. This analysis of almost half a million people by Johns Hopkins researchers entitled Enough Is Enough: Stop Wasting Money on Vitamin and Mineral Supplements, found that multivitamin use did not decrease the risk of cancer, heart disease or help with cognitive decline. Experts recommend that the best way to ensure an adequate intake of vitamins and minerals is to eat a healthy, balanced diet.

So if many popular nutritional supplements are of questionable benefit for healthy people and increasingly not often recommended by healthcare professionals, where are people with cancer getting the message that they should take these?

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Did Catherine Bell Geta Nose Job

Looking at thepicture above, you can see that there is a clear contrast in her nose shape inthe before and after snaps. Her nose appears to be more natural in thefirst one while it appears to have been worked upon on the second photo of CatherineBell today, with her nose having a more definite shape.

We believe thatthe star might have opted for rhinoplasty to slightly narrow down her nose bridge,while also making her tip pointed. What do you think?

Fuelling Breast Cancer Recurrence

Enhancing Lymph Node Transfer in Breast Cancer Related Lylphedema with collagen scaffolds
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Collagen within a residual breast tumor. Image credit: Walens et al. 2019

Breast cancer is the second-leading cause of cancer-related deaths in women. Recurrence of breast-cancer five or more years after initial diagnosis and treatment causes more than half of these deaths. This suggests that some tumor cells survived treatment and persisted undetected. These residual tumor cells may not grow for years and are often surrounded by other cells, including immune system cells. What role these surrounding immune cells play in triggering future growth of these residual tumor cells is not clear.

Many breast cancer patients receive chemotherapy, which kills all quickly dividing cells. Targeted therapies, which block signals necessary for cancer cell growth, are also used often. More recently, scientists have developed treatments that use a patients own immune system to fight off cancer. Scientists are currently studying whether combining these immunotherapies with chemotherapy or targeted therapies increases the likelihood of eliminating cancer. Learning more about the role surrounding immune cells play in allowing residual tumor cells to persist and regrow is important to understanding how to treat cancer more successfully and prevent recurrence.

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    Integrin Signaling Is A Key Mediator Of Chemoresistance In Tnbcs

    To elucidate the underlying mechanisms of chemoresistance in TNBCs, we modelled the clinical acquired resistance by using xenografts of the well-established TNBC cell line, MDA-MB-231,. Tumor-bearing mice were continuously treated with either vehicle or doxorubicin, and the fast-growing vehicle-treated mice were sacrificed, and tumors were denoted as vehicle. When tumors from the doxorubicin-treated group exhibited initial response to therapy and shrunk, tumors from some of the mice were collected and denoted as sensitive. The rest of the mice were kept under doxorubicin treatment until their tumors exhibited re-growth at rates comparable to vehicle-treated tumors, and those tumors were classified as resistant . The average growth curves and the Waterfall plot showing tumor volume fold change over time for vehicle-treated, doxorubicin-sensitive and -resistant tumors are depicted in Fig. , respectively.

    Fig. 1: Integrin signaling is a key mediator of chemoresistance in TNBCs.

    Estrogens And Breast Health

    The hormone that is fundamental to the female of the species is actually a family of three: estradiol, the most active form of estrogen estrone, the inactive storage form of estrogen and estriol, the weaker of the estrogens.

    Estrogen has been labeled the angel of life, because it makes cells grow, developing the uterus, breasts, periods, pregnancy and the egg within the ovaryand the angel of death, because in excess it becomes toxic to the body. As they say, too much of a good thing can be dangerous, and too much of an estrogen that causes cells to multiply out of control is a recipe for breast cancer. Determining symptoms of estrogen dominance is a smart move since an imbalance of high estrogen to low progesterone that goes undetected for too long is not a risk worth taking.

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