The Ohio State University Comprehensive Cancer Center
Raphael Pollock, M.D., Ph.D., Director
NCI designated The Ohio State University Comprehensive Cancer Center in 1976. The adult patient care component of the OSUCCC is the Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, which opened in July 1990. The cancer hospital was replaced in December 2014 by a much larger facility bearing the same namea 21-story, 1.1 million square foot, 356-bed facility that ranks as the third largest cancer hospital in the nation. The newer OSUCCC James is a transformational hospital that integrates researchers, clinicians, and educators more closely than ever to enhance cancer care for people throughout Ohio, nationally, and from around the world.
The OSUCCC James has a number of clinical partnersincluding The Ohio State University Wexner Medical Center and Nationwide Childrens Hospitalwho share the OSUCCC Jamess vision of creating a cancer-free world, one person and one discovery at a time. Researchers and clinicians at the OSUCCC James realize there is no routine cancer because each patients malignancy is biologically unique and must be treated with individualized therapies that target its molecular characteristics: the essence of personalized cancer care.
About Ohio State’s Breast Imaging Fellowship
The Stefanie Spielman Comprehensive Breast Center is a state-of-the-art, multidisciplinary outpatient clinic located in Columbus, Ohio. It is part of the Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, which is the third largest cancer hospital in the United States. The breast imaging section performs approximately 40,000 screening studies annually including 38,000 screening mammograms and 1,500 automated screening ultrasound exams. Approximately 10,000 diagnostic mammograms,10,000 breast ultrasound and 2,000 breast MRI exams are performed annually. Nearly 3,500 interventional procedures are performed each year and include mammographic and sonographically guided wire localizations, radiation seed placements and stereotactic, sonographic and MRI-guided core biopsies. The breast imaging section is staffed by nine fellowship-trained breast imagers who work solely at the breast center and accommodate multiple residents and 2 breast imaging fellows.
Hereditary High Risk Clinic
Cleveland Clinic offers a unique, hereditary high risk clinic to help manage the risk for individuals with identified mutations and untested family members, or a strong family history of breast cancer.
Characteristics that may suggest a hereditary predisposition include:
- diagnosis of breast cancer before age 50
- triple negative breast cancer
- several family members on the same side with breast and/or ovarian cancer or pancreatic cancer
- male breast cancer
- and/or a known familial gene mutation.
Early identification of patients at increased risk due allows for a proactive approach to care, including genetic counseling, education about lifestyle changes, enhanced surveillance, chemoprevention, and risk-reduction surgery.
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Outpatient Care / Ambulatory Visitors
- Visitors to all hospital locations must have a hospital-provided visitor sticker visible at all times while in the building
- Wear a hospital-provided mask over nose AND mouth at all times, including the exam room, regardless of vaccination status
- Practice good hand hygiene
- Visitors are allowed for patients with suspected or confirmed COVID-19
Can Children Visit The Hospital
Children under the age of 18 will be permitted to visit in most units however child visitation is not permitted in select patient care areas. Visitors may obtain more information about visitation by children at the nurses station. In patient care areas where child visitation is permitted, to assure the childs safety, children under the age of 18 must be accompanied and properly supervised by a non-patient adult at all times.
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Other Types Of Reconstructive Surgery For Cancer Treatment
The Ohio State Wexner Medical Center offers a wide range of treatments, including flap procedures, tissue transplants or other approaches and postsurgical therapies. Treatment and conditions treated include:
- Advanced lymphedema care from an elite Lymphedema Center of Excellence, offering innovative surgical solutions
- Arm, leg or other limb salvage and complex wound care
- Esophageal reconstruction
- Face, jaw and craniofacial reconstruction including injury related to brain or head and neck cancers
- Facial reanimation restores facial movement and functions, from blinking to eating and smiling after cancer-related injury
- Gynecological and urology cancers
- Hand reconstruction after cancer-related injury or amputation
- Head and neck cancer
- Sarcomas, bone and spine cancers
How We Test For The Brca Gene
A genetic test requires having blood drawn to examine your genes. If the blood sample shows that you have one of the mutated BRCA genes, a genetic counselor can talk to you about what steps you can take to prevent cancer and participate in early and regular screenings. Women have the option of removing their ovaries or breasts to reduce their odds of getting cancer in either organ.
The cost of testing has come down considerably over the past several years. And most insurances cover that cost as well as the fee for meetings with a genetic counselor.
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Statistical Design And Study Endpoints
The primary endpoint of the Phase I study was to determine the appropriate Phase II dose of bendamustine and erlotinib through assessment of treatment toxicity during the first cycle of treatment. Dose-limiting toxicity was defined based on toxicities possibly, probably, or definitely related to the study therapy observed during the first cycle and included: ANC< 1 Ã 109/L for > 7 days despite use of white blood cell growth factor support platelet count< 25 Ã 109/L for > 7 days, or associated with bleeding, or < 10 Ã 109/L at any time grade 4 rash or grade 3 rash not controlled with medical therapy grade 4 diarrhea or any other non-hematologic toxicity â¥grade 3 by NCI CTCAE version 3.0.
Patients were treated according to a Phase I 3 + 3 study design. The dose escalation scheme is shown in Table 1. All patients in each cohort were observed for the first cycle of treatment prior to dose escalation or expansion of a dose level. The Phase II dose was defined as the highest dose tested in which fewer than 2 of 6 patients experienced DLT attributable to the study drug.
Breast Cancer Stats & Facts For Ohio
Who Gets Breast Cancer?
- In Ohio in 2018, 9,832 invasive and 1,987 in situ breast cancer cases were diagnosed among females.
- Breast cancer accounted for 29% of all cancers in women in Ohio in 2018.
- Men can also get breast cancer 76 men in Ohio were diagnosed in 2018.
- 1 in 8 women in the United States who live to be age 85 will develop breast cancer.
Breast Cancer Deaths
- In Ohio in 2019, 1,744 deaths occurred among women from breast cancer. Overall, breast cancer death rates among women decreased 11% from 2010-2019.
- Black women have higher breast cancer death rates than white women.
Early Detection Is Important
- In Ohio in 2018, 72% of female breast cancers were diagnosed at an early stage .
- Nearly 100% of women in Ohio diagnosed with early stage breast cancer that has not spread SURVIVE 5 YEARS.
- 30% of women in Ohio diagnosed with breast cancer that has spread to distant organs SURVIVE 5 YEARS.
Get Screened for Breast Cancer
Regular mammograms can help find breast cancer early.
- The U.S. Preventive Services Task Force recommends mammogram screening every two years for women ages 50-74 who are at average risk.
- The decision to start screening mammography prior to age 50 should be an individual one. However, women with a parent, sibling, or child with breast cancer are at higher risk for breast cancer and may benefit more than average-risk women from beginning screening in their 40s.
For more information, see the ODH Cancer Data and Statistics webpage.
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Plastic And Reconstructive Surgery After Cancer
Reconstructive surgeons repair parts of the body injured by cancer and cancer treatment. The plastic and reconstructive surgeons at The Ohio State University Wexner Medical Center and The Ohio State University Comprehensive Cancer Center Arthur G. James Cancer Hospital and Richard J. Solove Research Institute share world-class expertise to treat all types of cancer. Our surgeons meet weekly and monthly to offer highly collaborative, integrated and personalized care.
Specialized reconstructive surgeons work across specialties to restore what cancer takes away. We perform natural breast reconstruction, complex nose or jaw reconstruction, novel lymphoma surgery, hand and limb surgery after osteosarcoma or other cancers, and more.
Reconstructive Microsurgery And Super
Most of the Ohio State Wexner Medical Center’s plastic and reconstructive surgery team have advanced fellowship-level microsurgery expertise. Some have subspecialty training in super-microsurgery, microvascular surgery and other areas. Using smart technologies, surgeons can operate on structures invisible to the naked eye. We repair nerves, restore blood flow and close wounds using threads as thin as a strand of hair. After treatment and rehab, patients at the Ohio State Wexner Medical Center are learning to walk, wave and smile again.
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Your Odds Of Having The Brca Gene
Having a mutated BRCA gene is common in the general population: 1 in every 400 people has one. Its even more common among Ashkenazi Jews, those whose ancestors are from central or eastern Europe. For them, the risk is 1 in 50.
If your mother or father inherited a mutated BRCA1 or BRCA2 gene, you have a 50% chance of also getting that mutated gene. Thats because half of your genes came from your mother half from your father.If a mutated version of the BRCA1 or BRCA2 gene is passed on to you, your cancer risk goes up sometimes significantly depending on the type of cancer and whether the mutation is on the BRCA1 gene or the BRCA2 gene.
You would be six times more susceptible to getting pancreatic cancer if you inherited a mutated BRCA1 gene and up to 14 times more susceptible if you inherited a mutated BRCA2 gene.
The risk of men developing breast cancer yes, men can get breast cancer, though rarely is 0.1% in the general population. But that risk rises modestly to 1.2% with a mutated BRCA1 gene and jumps to nearly 9% if you inherit a BRCA2 gene.
And your risk of getting prostate cancer sometime in your lifetime is over three times higher for men with a mutated BRCA2 gene compared to the general population.
You might think that if youre a man, you cant inherit cancer risks from your mother. You can. The same is true for women inheriting cancer risks from their dad.
The Ohio State University Comprehensive Cancer Center Arthur G James Cancer Hospital And Richard J Solove Research Institute
The Ohio State University Comprehensive Cancer Center Arthur G. James Cancer Hospital and Richard J. Solove Research Institute Arthur G. James Cancer Hospital and Richard J. Solove Research Institute strives to create a cancer-free world, one person, one discovery at a time through research that translates to innovative and highly targeted patient care.
The OSUCCC James is the only cancer program in the United States that features a National Cancer Institute designated comprehensive cancer center aligned with a nationally ranked academic medical center and a freestanding cancer hospital on the campus of one of the nations largest public universities.
At the Forefront of Research
The OSUCCC James is one of only 51 NCI-designated comprehensive cancer centers in the nation, a designation it has maintained through competitive renewal since 1976. After its most recent NCI site review, the cancer center earned the NCIs highest ranking, exceptional, for the third consecutive time and received a five-year NCI cancer center support grant.
Excellence in Cancer Care
The James Cancer Hospital and Solove Research Institute opened in 1990 as the Midwests first freestanding cancer hospital and the patient-care component of The Ohio State University Comprehensive Cancer Center. Ranked by U.S. News & World Report as one of the top hospitals in the nation for cancer care, the hospital is one of only 11 DRG-exempt or PPS-exempt institutions in the United States.
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With Brca Knowledge Is Power
Inheriting either one of the BRCA mutated genes is not a death sentence. At first, your response might be to feel doomed. And it could take some time to process the notion that you have a higher risk for some cancers.
Knowing your risk for cancer, though, is also an opportunity for you to find out how to prevent those cancers and begin regular screenings so that if cancer develops, you can stop it at the earliest stage before surgery is necessary.
See A Doctor Without Leaving The House
It is easier than ever to connect with our experts from the comfort of your home. Telehealth visits are open to new and existing patients. You can receive treatment for many conditions from an Ohio State health care provider remotely. Instead of coming into the office for your appointment, use your smartphone, tablet or computer to connect with your doctor. If you do not have access to an internet connection or device with audio and video, you may still be able to communicate with your doctor using a landline telephone.
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The Ohio State University Comprehensive Cancer Center James Cancer Hospital And Solove Research Institute
As the countrys third-largest cancer hospital, OSUCCC James serves as an innovative model for 21st-century cancer care. The facility brings together clinical care, research and education in a highly subspecialized care model called precision cancer medicine.
Each inpatient unit has its own cancer focus, such as gastrointestinal, head and neck, breast, genitourinary or hematologic malignancies. The highly specialized oncologists, nurses, pharmacists and genomic experts in each unit treat only that type of cancer. Medical staff collaborate with researchers to target the molecules and markers fueling each persons unique cancer. Translational research labs on inpatient floors bring together physicians and researchers to develop targeted treatments.
Sophisticated technology supports patient care at every stage of treatment. Hotel-like amenities accommodate families and visitors. Each floor has visitor lounges, consultation rooms, Wi-Fi capabilities and respite areas.
Natural light throughout the hospital supports the physical and mental well-being of patients. An above-ground radiation oncology center on the second floor provides access to natural light and views. Patients, visitors and staff can enjoy outdoor cafés and terrace gardens on the 14th floor.
A cancer emergency departmentone of only a few in the U.S.is part of the main emergency department and staffed by specially trained doctors and nurses.
The Ohio State University Wexner Medical Center
Training Program Director: Bridget Oppong, MD
About the Program
The Ohio State Wexner Medical Center is composed of six hospitals including the Arthur G. James Cancer Center and Richard J. Solove Research Institute. We obtained NCI designation first in 1976 and remain 1 of 51 NCI Comprehensive Cancer Centers. The current dedicated cancer center, the New James Cancer Hospital opened in 2014 and is one of the largest dedicated cancer hospitals in a U.S. academic medical center. We are co-located with seven health science colleges fostering a strong culture of research collaboration. Serving 10,000 cancer patients annually we have remarkable institutional commitment and robust community support throughout the tri-state area .
Breast cancer care is delivered in the Stefanie Spielman Comprehensive Breast Center, a state-of-the-art facility built in 2011 housing surgical, medical, and radiation oncology in additional to a plethora of supportive services. We treat ~1,000 analytic cases among the eight breast surgical oncologists, ten medical oncologists, six plastic and reconstruction surgeons, and five radiation oncologists.
Research Opportunities and Mentorship
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Why Choose Cleveland Clinic For Breast Cancer Care
Our Comprehensive Breast Cancer Program is one of the largest and most specialized in the nation. As part of the Case Comprehensive Cancer, we are one of only 41 comprehensive cancer centers in the nation designated by the National Cancer Institute. Cleveland Clinic has also achieved a Three Year Full Accreditation from the American College of Surgeons’ National Accreditation Program for Breast Centers . Cleveland Clinic is ranked as one of the nations top hospitals by U.S. News & World Report.
Our multidisciplinary physician team of breast surgeons, medical oncologists, radiation oncologists, radiologists, and plastic surgeons work together to provide customized, coordinated care for patients. We offer the highest-quality screening, diagnosis and treatment of breast cancer.
We are a national leader in intraoperative radiation therapy, novel targeted therapies and adjuvant therapies for breast cancer, and also in fertility preservation for cancer patients. We also participate in important clinical trials of brand new therapies and our patients have access to these trials for every stage of breast cancer. Our cancer specialists are pursuing many promising avenues of research including the development of a breast cancer vaccine to bring hope to future patients as well.
- Breast Cancer in Young Women
- Breast Cancer in Men
- The Diagnosis is Breast Cancer
Breast Cancer Q& A
Research At The Osuccc James
The OSUCCC James has nearly 300 researchers who represent 11 of the 15 colleges at Ohio State University and other academic institutions such as Nationwide Childrens Hospital and Cincinnati Childrens Hospital Medical Center. Each scientist is a participant in one of five interactive research programs within the comprehensive cancer center: Cancer Biology, Cancer Control, Leukemia Research, Molecular Carcinogenesis and Chemoprevention, and Translational Therapeutics.
The work of these multidisciplinary teams of scientists contributes to the OSUCCC Jamess mission of rapidly translating groundbreaking discoveries into innovative patient care via sponsorship of hundreds of clinical trials on the latest therapiessome of which are available nowhere else. The OSUCCC James is one of only a few comprehensive cancer centers funded by the NCI to conduct phase 1, phase 2, and phase 3 clinical trials of NCI-sponsored novel cancer drugs.
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