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Survival Rate Inflammatory Breast Cancer

Inflammatory Breast Cancer Survival Rate

What is the survival rate for breast cancer | Norton Cancer Institute

The inflammatory breast cancer survival rate is sometimes used as a standard way for physicians and researchers to predict a patients prognosis. While some patients find this information helpful, others do not, so learning about survival rates is largely a matter of personal preference.

Survival rates are often referred to in terms of median survival, which is the length of time for half of the patients in a large group to survive. It is important to keep in mind that the median is simply a point of reference that is used by physicians and researchers. No single patient can be considered average, and it is impossible to predict what will happen in any individual case. Many patients experience much better outcomes than the median suggests. Additionally, there are many factors that the median does not take into account, including risk factors that can influence a patients outcome.

Nevertheless, there are several factors that have been found to improve the survival rate of inflammatory breast cancer patients, such as:

  • Early detection
  • Aggressive treatment, including chemotherapy and radiation
  • How well the cancer responds to treatment
  • Eligibility for surgery
  • Overall health and wellness

If you have any questions about the inflammatory breast cancer survival rate, Moffitt is here to help. Call Moffitt at , or fill out our new patient registration form online to get started. No referral is necessary to meet with our breast cancer team.

Individuals With Inflammatory Breast Cancer At Higher Risk Of Cancer Spread To The Brain

– New research indicates that among individuals with breast cancer, those with a rare subtype called inflammatory breast cancer face a higher risk that their cancer will spread, or metastasize, to the brain. The study is published by Wiley online in CANCER, a peer-reviewed journal of the American Cancer Society.

Studies have demonstrated higher rates of brain metastases in patients with inflammatory breast cancer, but detailed information is lacking. To provide insights into the incidence and risk factors for brain metastases in this patient population, Laura E.G. Warren, MD, of the Dana-Farber Cancer Institute, and her colleagues analyzed data on 372 patients with stage III inflammatory breast cancer and 159 with stage IV inflammatory breast cancer.

Over a median follow-up of 5 years, the incidence of brain metastases at 1, 2, and 5 years was 5%, 9%, and 18% among patients who presented with stage III disease, and 17%, 30%, and 42% among those with stage IV disease. Patients with triple-negative breast cancer faced a particularly high risk, and when they did experience brain metastases, their survival time was shorter than those with hormone receptorpositive or HER2-positive breast cancer who experienced brain metastases. Higher risks of brain metastases were also seen in patients whose cancer had metastasized to other parts of the body besides the brain, especially when this occurred at a young age.

Link to Study:

Survival Rates By Stage

Breast cancer survival rates compare the number of women with breast cancer to the number of women in the overall population to estimate the amount of time women with breast cancer are likely to live after theyre diagnosed.

For example, if the survival rate for a stage of breast cancer during a 5-year period is 90 percent, it means that women diagnosed with that cancer are 90 percent as likely to survive for 5 years following their diagnosis as women who do not have the cancer.

As we mentioned earlier, survival rates are based on information from the SEER database, which the NCI maintains.

SEER does not group breast cancers by stages 0 through 4. Instead, it groups them by the following stages:

  • localized: when the cancer has not spread outside of the breast
  • regional: when its spread outside the breast to nearby structures or lymph nodes
  • distant: when its spread to other parts of the body, such as the liver, lungs, or bones

It should be noted that theres a substantial racial disparity gap in survival rates between white women and Women of Color, especially for late-stage breast cancer diagnoses. The chart below, courtesy of the

11.6

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Survival Analysis Using Cox Proportional Hazard Models

Among the textural features, lower mean attenuation , lower SD , lower MPP , and lower entropy on CT images were associated with worse OS in univariate analysis . Collinearity was observed between all the textural features . Because of this collinearity, each dichotomized CT textural feature was analyzed with M1 stage, using a multivariate Cox proportional hazards model. In multivariate analysis, lower mean attenuation , lower MPP , and lower entropy on post-contrast CT images were significant factors in predicting worse OS, independent of M1 stage .

Table 3. Univariate Cox proportional hazard analysis of CT texture features associated with worse overall survival.

Table 4. Multivariate Cox proportional hazard analysis of clinicopathologic variables and CT texture features without image filtration associated with worse overall survival.

Who Is Likely To Have Inflammatory Breast Cancer

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Anyone can develop inflammatory breast cancer, but certain factors may raise your risk.

  • Gender: IBC can affect people of all genders, but its more common in women and people assigned female at birth .
  • Age: People with IBC tend to be younger than people with other forms of breast cancer. Inflammatory breast cancer is most commonly diagnosed in women and people AFAB who are younger than 40. The median age of diagnosis is 57.
  • Race: People who are Black are more likely to get diagnosed with IBC than people who are white.
  • Weight: People with obesity or overweight are more likely to get diagnosed than people with a BMI that falls within the normal range.

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How Long Do People With Inflammatory Breast Cancer Live

Percent means how many out of 100. The 5-year survival rate for people with inflammatory breast cancer is 41%. However, survival rates vary depending on the stage, tumor grade, certain features of the cancer, and the treatment given. If the cancer has spread to the regional lymph nodes, the 5-year survival rate is 56%.

What Is Inflammatory Breast Cancer

Inflammatory breast cancer is a rare and very aggressive disease in which cancer cells block lymph vessels in the skin of the breast. This type of breast cancer is called inflammatory because the breast often looks swollen and red, or inflamed.

Inflammatory breast cancer is rare, accounting for 1 to 5 percent of all breast cancers diagnosed in the United States. Most inflammatory breast cancers are invasive ductal carcinomas, which means they developed from cells that line the milk ducts of the breast and then spread beyond the ducts.

Inflammatory breast cancer progresses rapidly, often in a matter of weeks or months. At diagnosis, inflammatory breast cancer is either stage III or IV disease, depending on whether cancer cells have spread only to nearby lymph nodes or to other tissues as well.

Additional features of inflammatory breast cancer include the following:

  • Compared with other types of breast cancer, inflammatory breast cancer tends to be diagnosed at younger ages.
  • Inflammatory breast cancer is more common and diagnosed at younger ages in African American women than in white women.
  • Inflammatory breast tumors are frequently hormone receptor negative, which means they cannot be treated with hormone therapies, such as tamoxifen, that interfere with the growth of cancer cells fueled by estrogen.
  • Inflammatory breast cancer is more common in obese women than in women of normal weight.

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Inflammatory Breast Cancer Prognosis

The prognosis, or likely outcome, for a patient diagnosed with cancer is often viewed as the chance that the cancer will be treated successfully and that the patient will recover completely. Inflammatory Breast Cancer treatment outcome would depend on all of the following factors like:

  • Stage of the IBC
  • Type and location of the cancer
  • Medical History and health condition of the patient
  • Also, Women with Stage III have better chances of coming out of IBC easily than women in Stage IV. Women with grade I or grade II tumors have better prognosis. Chances are less with grade III tumors. Women with estrogen receptor positive have better prognosis.

    Heres What You Need To Know About Inflammatory Breast Cancer

    2YH: Breast cancer survival rates increase with early detection, treatment

    Inflammatory breast cancer is a rare and aggressive form of the disease that doesnt get a lot of attention. Its tough to diagnose because of its unusual symptoms, and its more common in young women which makes it particularly tricky since the symptoms mimic that of mastitis, a common breast infection in new moms who breastfeed. Heres what you need to know:

    Symptoms

    The symptoms for IBC dont appear like regular breast cancers. First off, you dont often find a lump. Instead, your breast may appear red, itchy, swollen, warm and tender. This happens because of the way the cancer cells have formed in the breast. They block the lymph vessels in your skin causing infection-like symptoms instead of one solid lump.

    Treatment

    When IBC is initially diagnosed it is always considered locally advanced. This is because it has already spread to surrounding tissue in the skin and/or lymph nodes. Further tests are done to confirm if it has spread beyond local tissue to distant organs, known as stage IV or metastatic. It can be a very aggressive, fast-growing cancer so treatment can also be aggressive.

    Statistics

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    Data Paints A More Complete Picture

    The U-M study analyzed data from the National Cancer Institutes known as Surveillance, Epidemiology, and End Results, or SEER. The analysis was unique in including not only patients who had a diagnosis of IBC based on pathology reports, but also those with clinical symptoms consistent with IBC bringing the number of patients included in the study to nearly 30,000.

    The team included two epidemiologists from the U-M School of Public Health: Yaoxuan Xia and Bhramar Mukherjee, Ph.D., chair of the department of biostatistics and a member of the Rogel Cancer Center.

    We found that in these additional patients, the incidence rates by race were consistent with previously reported trends. This gave us confidence that our method was uncovering additional cases that had gone underreported in the past or were possibly misclassified in previous analyses, says study senior author Sofia Merajver, M.D., Ph.D., director of the Breast and Ovarian Cancer Risk and Evaluation Program at the Rogel Cancer Center. So therefore we believe our study is able to offer the most comprehensive assessment of incidence and survival rates of IBC to date.

    Clinical Trials For Ibc

    Research is ongoing to improve treatment for IBC.

    New therapies are being studied in clinical trials. The results of these trials will decide whether these therapies will become part of the standard of care.

    After discussing the benefits and risks with your health care provider, we encourage you to consider joining a clinical trial.

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    What Is The Prognosis Of Patients With Inflammatory Breast Cancer

    The prognosis, or likely outcome, for a patient diagnosed with cancer is often viewed as the chance that the cancer will be treated successfully and that the patient will recover completely. Many factors can influence a cancer patients prognosis, including the type and location of the cancer, the stage of the disease, the patients age and overall general health, and the extent to which the patients disease responds to treatment.

    Because inflammatory breast cancer usually develops quickly and spreads aggressively to other parts of the body, women diagnosed with this disease, in general, do not survive as long as women diagnosed with other types of breast cancer.

    It is important to keep in mind, however, that survival statistics are based on large numbers of patients and that an individual womans prognosis could be better or worse, depending on her tumor characteristics and medical history. Women who have inflammatory breast cancer are encouraged to talk with their doctor about their prognosis, given their particular situation.

    Ongoing research, especially at the molecular level, will increase our understanding of how inflammatory breast cancer begins and progresses. This knowledge should enable the development of new treatments and more accurate prognoses for women diagnosed with this disease. It is important, therefore, that women who are diagnosed with inflammatory breast cancer talk with their doctor about the option of participating in a clinical trial.

    Survival For Inflammatory Breast Cancer

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    Many factors can influence life expectancy for women with inflammatory breast cancer. These include:

    • the exact position of the cancer
    • how big the cancer is and whether it has spread only to the lymph nodes or to other organs
    • how abnormal the cancer cells look under the microscope
    • whether the cancer cells have receptors for hormone therapies
    • how well the cancer responds to treatment

    Inflammatory breast cancer can develop quickly and may spread to other parts of the body. So, in general, the outlook with this type is not as good as for women diagnosed with other types of breast cancer. But doctors think that the outlook is improving as breast cancer treatment improves.

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    Are There Home Remedies For Inflammatory Breast Cancer

    Although home remedies are not appropriate for the treatment of inflammatory breast cancer, it is important to maintain a healthy lifestyle while undergoing medical treatment. This includes maintaining your general health by eating a healthy diet, smoking cessation, exercising, and getting adequate rest and sleep.

    What Are The Stages Of Inflammatory Breast Cancer

    Staging of cancer refers to the determination of how far the tumor has spread at the time of diagnosis. Staging is determined by a variety of methods including results from surgical procedures, lymph node biopsy, and imaging tests. Staging is important because it aids in developing a treatment plan.

    • Cancer in situ is referred to as stage 0 because the tumor cells are located in the breast ducts and have not invaded the surrounding tissue.
    • Invasive breast cancers are staged along a scale of I to IV, with stage I being the earliest stage and stage IV representing tumors that have metastasized to other parts of the body like the bones, lungs, or brain.
    • Because inflammatory breast cancers have already spread into the lymphatic vessels and cause symptoms related to this presence in the lymphatic system, all inflammatory breast cancers are stage III or stage IV at diagnosis.

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    Inflammatory Breast Cancer: A Panoramic Overview

    Sangjucta Barkataki1,2, Madhura Joglekar-Javadekar1,2, Patti Bradfield3, Thomas Murphy1, Diana Dickson-Witmer2,4 and Kenneth L. van Golen1,2*

    1The University of Delaware Department of Biological Sciences, Newark, DE, USA

    2The Center for Translational Cancer Research, Newark, DE, USA

    3The Inflammatory Breast Cancer Foundation, Newark, DE, USA

    4The Breast Center at the Helen F. Graham Cancer Center, Christiana Care Health System, Newark, DE 19716-2500, USA

    Abstract

    Inflammatory breast cancer is a unique breast cancer with a highly virulent course and low 5- and 10-year survival rates. Although IBC only accounts for 1-5% of breast cancers it is estimated to account for 10% of breast cancer deaths annually in the United States. The accuracy of diagnosis and classification of this unique cancer is a major concern within the medical community. Multimodality treatment includes preoperative chemotherapy, mastectomy, and radiation therapy is the therapeutic mainstay and has been shown to improve prognosis. The potential for inaccurate diagnosis and misclassification in cases of IBC is increased by many factors. This includes the misleading initial symptoms of IBC. The early signs of IBC will present in women who have inflammation of the skin of the affected breast, as well as red or purple coloration of the inflamed area. Molecular studies have shown unique signature genes that are hallmarks of IBC. The current article reviews multiple aspects of primary inflammatory breast cancer.

    Cost And Financial Assistance

    Breast Cancer Survival Rate

    The cost of treatment varies depending on the type of treatment and stage of the cancer but can range from $60,637 to $134,682 in the first year after diagnosis.

    If youre struggling to cover the cost of treatment, Golshan recommends looking into organizations that offer financial assistance, such as:

    Most hospitals and healthcare facilities have financial counselors who can work out a payment plan with you and direct you to assistance programs.

    Additionally, some pharmaceutical companies have set up special funds that cover all or part of the cost of their cancer medicines.

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    What Questions Should I Ask My Doctor

    Ask your healthcare provider about what your cancer diagnosis means for your treatment options and likely outcomes. Questions to ask include:

    • What stage is my breast cancer?
    • Which specialists will be involved in my care?
    • What treatment options would you recommend?
    • What outcomes should I expect from treatment?
    • What are potential side effects or complications related to treatment?
    • Can you connect me with resources ?

    A note from Cleveland Clinic

    Inflammatory breast cancer is a rare type of cancerthat spreads quickly. Schedule an appointment with your healthcare provider immediately if you notice changes in your breasts, especially a change in one breast but not the other. The changes may be a sign of a less serious condition, like an infection. Still, IBC spreads fast. If your symptoms are a sign of inflammatory breast cancer, youll want to begin treatment as early as possible. Dont delay seeking care that can potentially improve your prognosis.

    Interobserver And Intraobserver Agreement

    For interobserver agreement, the ICC between two readers was calculated. The ICC was 0.77 for mean, 0.81 for SD, 0.82 for entropy, 0.80 for MPP, 0.28 for skewness, and 0.16 for kurtosis. For intraobserver agreement, the ICC for reader 1 was 0.98 for mean, 0.93 for SD, 0.98 for entropy, 0.99 for MPP, 0.32 for skewness, and 0.18 for kurtosis, and that for reader 2 was 0.95 for mean, 0.90 for SD, 0.91 for entropy, 0.95 for MPP, 0.30 for skewness, and 0.19 for kurtosis.

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