What Dictates How Vitamin E Supplements Affect Cancer Risk
There is a longstanding debate as to whether taking vitamin E supplements increases or decreases a persons risk of developing cancer. A new study suggests that both outcomes are a possibility and also explains why.
Many people believe that taking supplements can improve their well-being and decrease their risk of developing numerous health problems.
However, some recent research has suggested that supplements may not, in fact, bring any health benefits. Certain studies including this one that Medical News Today covered have gone so far as to suggest that particular dietary supplements could even harm health.
Still, vitamin supplements remain popular. According to preliminary 2018 data that the Council for Responsible Nutrition in the United States released, approximately 78 percent of people in the U.S. believe that the dietary supplement industry is trustworthy.
Moreover, as Brian Wommack, senior vice president of communications at CRN, reports, Three-quarters of Americans take dietary supplements.
A new study by researchers from Brigham and Womens Hospital in Boston, MA has been looking into the effects of vitamin E on cancer risk both overall, and in relation to specific forms of cancer and asking what factors might influence that effect.
This made it easy to assume that vitamin E just doesnt work. But, what weve found is that it may have been protective in some and not in others, and that genetic variation is linked to these outcomes, she adds.
Vitamins And Minerals In Supplements
Your doctor may recommend certain vitamins and supplements to help you stay healthy after treatment.
Calcium.Chemotherapy can weaken your bones. A calcium supplement with vitamin D, which helps your body absorb calcium, may protect your bones from changes due to treatment.
Multivitamin. A regular multivitamin may help you get essential vitamins and minerals to improve your overall health.
Probiotics. Probiotics help boost immunity, says Tara Scott, MD, a womens health specialist in Akron, OH. This may help you stay healthy after your treatment. Probiotics have anti-inflammatory effects, which may help protect against cancer. But there isnt enough research yet to know for sure.
Vitamin D. Experts say theres a link between low levels of vitamin D and breast cancer. Theres no evidence a vitamin D supplement will lower your risk of recurrence, but your doctor may recommend it for your overall health.
Continued
Preventionand Treatment Of Breast Cancer
Provitamin A: The provitamin A are mainly provided from -carotene, -carotene and -cryptoxanthin, however, some carotenoids such as lutein, for example, selectively induced apoptosis in MCF-7 BC cells but not in normal human mammary cells . It was reported that -carotene , at the physiologically concentration of just 1 M, can decrease the expression of Bcl-2 and PARP, and NF-kB in human BC MCF-7 cells by inhibiting the genes regulation of hormone involved in proliferation of cells. Fact, -carotene treatments can also inhibit the activation of Akt and Erk1/2, subsequently decreasing phosphorylation of Bad and downregulate superoxide dismutase-2 , its transactivation factor Nrf-2, and Endoplasmic Reticulum stress marker X-box Binding Protein 1 levels . Several lines of evidence suggest that carotenoids such as lycopene, -carotene, lutein, and astaxanthin have the ability to modulate the NF-B pathway, in some cases by inhibiting cancer cell growth via NF-B pathway .
Read Also: Puckering Of The Skin Breast Cancer
Natural Remedy To Cancer & Tumors
On this page, youre going to discover a remedy that has helped patients for both in Ghana and Abroad shrink and get rid of Cancerous or Tumorous Cells, some who were even in danger of death.
Reading the information on this article and acting on them will help you get your permanent freedom from Cancer or any Cancer related Ailments.
Read through the story of a Friends Mother and What Advise she has for You.
Patricia Daniel, 55, says shes finally beginning to feel like herself again. She recently returned to her job working with children who have special needs, and shes growing a support group of people in her community whove been diagnosed with cancer. She has only 1 more treatments of The Capsules our targeted therapy drug to kill her breast cancer tumors. After that, she said, I can go back to the life I once had.
Patricias life was turned upside down in October 2016 when she was called back after her regular, yearly mammogram. Biopsies found cancer in 2 lumps in her left breast and in lymph nodes under her arm. More tests found that her cancer was HER2-positive. Although this tends to be a very aggressive cancer, several drugs have been developed that target the protein on the cancer cells that help them grow, but most of the drugs have failed.
Now i would love to share with everyone the medication that helped me get rid of Cancer.
Should You Be Worried About Your Breast Cancer, Cervical, Lung, Prostrate Or Leukaemia Or Any Type Of Cancer?
THE ANSWER IS NO
Clinical Trials Of Vitamin D
Clinical trials have been conducted using the dietary supplement, vitamin D3 , which is a precursor to calcitriol, the active metabolite. Administering vitamin D3 to raise serum 25-hydroxyvitamin D D) levels may allow for local production of calcitriol in target tissues, with a lower risk of hypercalcemia, hypercalciuria, and kidney stones. A meta-analysis was conducted of eighteen randomized controlled trials of vitamin D supplementation , which included over 57,000 participants and had fracture incidence as the main primary outcome . The study demonstrated that all-cause mortality was reduced by 7% in the vitamin D group . Another analysis of nineteen randomized controlled trials of vitamin D with or without calcium supplementation, including 16 trials with fracture outcomes and 3 with cancer as the primary endpoint, found insufficient evidence to support vitamin D supplementation for cancer prevention . Of note, most trial participants were postmenopausal women over the age of 65 years.
An alternative strategy to reduce the risk of hypercalcemia with calcitriol is to use noncalcemic vitamin D analogs. In phase I trials in a total of 58 patients with advanced breast cancer, colorectal cancer, and hepatocellular carcinoma, the calcitriol analog EB1089 caused stable disease in 6 patients for over 3 months and partial to complete remission in 2 patients .
Read Also: Blood Test For Breast Cancer Gene
Expression Of Mr 43000 Fas
In an effort to understand how VES was rendering Fas-resistant cells Fas-sensitive, levels of Mr 43,000 Fas protein were determined. Whole-cell extracts from the Fas-sensitive cell lines exhibited high levels of constitutively expressed Mr 43,000 Fas . In contrast, whole-cell extracts from Fas-resistant cell lines did not express detectable levels of Mr 43,000 Fas . However, prolonged exposure of immunoblots of whole-cell extracts from VEH-treated and VES-treated MCF-7, MDA-MB-231, and MDA-MB-435 cells revealed detectable levels of Mr 43,000 Fas . . Fas levels in whole cell extracts were not affected by VES treatment . Levels of Mr 43,000 Fas expressed by T47D cells treated with VEH and VES , after prolonged immunoblot exposure, are presented for comparative purposes . VES treatment had little to no effect on levels of Mr 43,000 Fas expressed in T47D whole-cell extracts .
Dosing And Toxicity Of Vitamin D Supplements
Vitamin D deficiency is often defined as a circulating 25-hydroxyvitamin D D) level of less than 20ng/mL . Sufficient blood concentrations of 25D generally focus on bone health, with a common definition of an optimal level of 30 or 32ng/mL which maximally suppresses serum parathyroid hormone . By these standards, the majority of the European and US populations are vitamin D insufficient or deficient.
In recent years, accumulating evidence suggests that daily doses as high as 10,000IU are safe. For example, in healthy subjects at a northerly latitude, cholecalciferol 4000IU daily for 5 months caused no harm and raised vitamin D levels to the desirable level in 88% of subjects . In a review of clinical trial data on the safety of high-dose vitamin D3, the authors concluded that the absence of toxicity in trials conducted in healthy adults that used vitamin D doses 10,000IU daily supports the selection of this value as the tolerable upper intake level .
Vitamin D toxicities, including hypercalcemia, hypercalciuria, bone demineralization, and nephrocalcinosis, are rare and generally only occur when serum 25D concentrations rise above 150ng/mL . In addition, the Women’s Health Initiative randomized controlled trial found a 17% increase in the incidence of kidney stones with calcium and vitamin D supplementation compared to placebo . Therefore, the potential benefits of vitamin D supplementation for chronic disease prevention need to be carefully weighed against possible harms.
Read Also: Is There Pain With Breast Cancer
When Lumps Are Cancerous
Animal studies in the early 2000s by Brigham and Women’s Hospital seemed to indicate that there is a link between supplementing the diet with alpha-tocopherol/vitamin E and reduced risk of cancer. However, the answer is not so cut and dried.
A 2019 review of studies by Brigham and Women’s Hospital revealed that the effect of vitamin E depends on your genetics, specifically, the COMT gene. For some, it can reduce the risk of cancer. In others, it can increase the risk.
Still, vitamin E might have positive effects on those who do develop cancerous lumps. A 2018 study by the University of North Carolina showed that vitamin E can reduce toxicity caused by radiation treatment. When used in conjunction with the medication Pentoxifylline, it is also useful in treating and preventing radiation-caused fibrosis in breast cancer patients.
Vitamin E Chemopreventive Potential
Although vitamin E is a popular supplement marketed for its potential beneficial antioxidant effects for a number of chronic diseases, including various forms of cancer, a Food and Nutrition Board panel on Dietary Reference Intakes for vitamin C, vitamin E, selenium, and carotenoids concluded that observational epidemiological studies provide only limited evidence for a protective association of vitamin E with lung cancer . Furthermore, the Food and Nutrition Broad concluded that data from randomized clinical trials, which are considered the gold standard for health research, are suggestive for the ability of vitamin E to prevent prostate cancer but caution that this information is from a single trial that needs to be confirmed and that this study was not designed to examine the correlation between vitamin E and prostate cancer .
Preventive studies using chemically induced mammary cancer in Sprague Dawley rats and dietary supplementation of vitamin E-adequate diets with various forms of vitamin E concluded that there was only limited or no evidence for a protective effect .
Also Check: How To Know If Breast Cancer Spread To Lymph Nodes
Vitamin E Can Reduce Pain
A study published in 2017 in the Journal of Education and Health Promotion showed that taking 400 international units of vitamin E per day for two months can help alleviate breast pain that comes with your menstrual cycle. Make sure your doctor examines any breast lump or pain that’s constant or doesn’t happen in conjunction with your menstrual rhythm.
Other changes along with vitamin E supplementation can help reduce tenderness and lumps. Eliminate caffeine, increase exercise and decrease dietary fats from animal sources such as dairy and meat. Get fitted for a supportive bra, use warm compresses in painful areas and don’t smoke.
Soy Proteins And Soy Isoflavones And Breast Cancer Outcomes
There are studies that have examined the association between soy products and isoflavones intake and breast cancer survival, however the results are not definitive . There are prospective cohort and meta-analyses studies that have reported significant inversely association between soy protein and soy isoflavones and breast cancer survival outcomes. In looking at prospective studies, The Shanghai Breast Cancer Survival Study comprised of 5,033 surgically treated breast cancer patients that were followed for 3.9 years. High soy protein intake was inversely associated with breast cancer recurrence and all-cause mortality among women with either estrogen receptor-positive or -negative breast cancer . In an earlier prospective study of 256 Chinese women, elevated soy isoflavones intake was associated with reduced risk of breast cancer mortality and high soy protein was also concomitant with significant decreased breast cancer risk . In another study published in the same year involving 339 Korean women, dietary soy isoflavones was inversely related with breast cancer recurrence in HER2-positive breast cancer patients while no effect was observed with total soy intake .
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Effect Of Vitamin C And E In Breast Cancer Patients Undergoing Chemotherapy
| The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. |
| Verified July 2020 by Dr. Fatisha Khanam, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh. Recruitment status was: RecruitingFirst Posted : July 9, 2020Last Update Posted : July 9, 2020 |
Effect of Vitamin C and Vitamin E in Breast Cancer patients undergoing Chemotherapy.
Purpose of the study:
The present study has been designed to assess the effects of vitamin C and vitamin E superimposed upon chemotherapeutic agents where the antioxidant vitamin C and vitamin E would be concurrently applied to breast cancer patients.
Method:
Ethical consideration:
The study will follow the principles of the Declaration of Helsinki and the World Medical Assembly. Patients will be informed about the study in easy language and then informed consent will be taken. This study has no potential risk to the patients. Confidentiality will be strictly maintained.
| Drug: Vitamin C, Vitamin E | Not Applicable |
Can Supplements Prevent Breast Cancer From Coming Back
So far, theres no proof that any vitamin, mineral, or herbal supplement can treat breast cancer or prevent it from coming back.
To date, there are no studies which demonstrate that certain supplements will lower your risk of recurrence, Johnson says. They may help with symptoms, but there isnt enough research to support using them to prevent breast cancer.
But there are other things you can do to lower your risk of breast cancer coming back. Make these lifestyle changes:
- Eat a healthy diet.
Read Also: How To Check Breast Cancer At Home
Cancer & Tumor Permanent Solution
On this page, youre going to discover a remedy that has helped patients for both in Ghana and Abroad shrink and get rid of Cancerous or Tumorous Cells, some who were even in danger of death.
Reading the information on this article and acting on them will help you get your permanent freedom from Cancer or any Cancer related Ailments.
Read through the story of a Friends Mother and What Advise she has for You.
Patricia Daniel, 55, says shes finally beginning to feel like herself again. She recently returned to her job working with children who have special needs, and shes growing a support group of people in her community whove been diagnosed with cancer. She has only 1 more treatments of The Capsules our targeted therapy drug to kill her breast cancer tumors. After that, she said, I can go back to the life I once had.
Patricias life was turned upside down in October 2016 when she was called back after her regular, yearly mammogram. Biopsies found cancer in 2 lumps in her left breast and in lymph nodes under her arm. More tests found that her cancer was HER2-positive. Although this tends to be a very aggressive cancer, several drugs have been developed that target the protein on the cancer cells that help them grow, but most of the drugs have failed.
Now i would love to share with everyone the medication that helped me get rid of Cancer.
Should You Be Worried About Your Breast Cancer, Cervical, Lung, Prostrate Or Leukaemia Or Any Type Of Cancer?
THE ANSWER IS NO
Effects Of Vitamin E On Doxorubicin Cytotoxicity In Human Breast Cancer Cells In Vitro
Document Type : Research Articles
1 Gastrointestinal Cancer Research Center, Non-Communicable Disease Institute, Mazandaran University of Medical Science, Sari, Iran.
2 Department of Pharmaceutics, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.
Abstract
Keywords
- Receive Date: 16 August 2021
- Revise Date: 02 November 2021
- Accept Date: 08 January 2022
Also Check: How To Use Cannabis Oil For Breast Cancer
Lycopene And Breast Cancer Risk
The consumption of fruits and vegetables particularly those containing lycopene may offer protection against different types of cancers including breast cancer. There are a number of prospective and casecontrol studies that examined the relationship between dietary lycopene and breast cancer risk. In a casecontrol study conducted among Chinese women comprising of 122 primary breast cancer cases and 632 age-matched healthy females, high intake of dietary lycopene was statistically strongly associated with lower breast cancer risk . In the Womens Health Initiative Observational Study comprising 84 805 women with reported 2,879 incident breast cancer cases during a follow-up period of 7.6 years, high intake of dietary lycopene non-significantly reduced breast cancer risk by 15% in ER+ and PR+ breast cancer among post-menopausal women . Also, a Swiss casecontrol study comprising 289 incident breast cancer cases and 442 controls reported a significant inverse association for lycopene with breast cancer risk .
Tocotrienols Induce Breast Cancer Cell Death
The objective of any cancer therapy is to induce the cancer cells to differentiate in a way that promotes programmed cell death . Several studies indicate that tocotrienols induce breast cancer cell apoptosis.41-43
When different kinds of live breast cancer cells were injected into the mammary tissue of female mice, tocotrienols were found to be growth inhibitory on each breast cancer cell line tested. Although apoptosis could be achieved, the dose of tocotrienol needed to induce 50% apoptosis was 2-4 times higher than the dose of tocotrienol required to induce 50% growth inhibition.42
It is interesting to note that the growth inhibition and promotion of apoptosis occur preferentially in the cancerous part of the breast so that healthy cells remain largely unaffected.42
Tocotrienols should be taken with food
For oil-soluble vitamin E to be absorbed, it should be taken with some kind of food. When people take oil-based vitamin E preparations on an empty stomach, very little makes its way into the bloodstream.
It is especially important to take the tocotrienols with some form of oil or fat-containing food. One study showed that when tocotrienols are taken on an empty stomach, absorption was reduced by an average of 64%.44
When taking gamma tocopherol and/or tocotrienol vitamin E supplements, try to take them with a meal or with fatty acid capsules like fish oil , GLA, CLA etc.
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