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What Are The Odds Of Surviving Triple Negative Breast Cancer

Age And Stage For Breast Cancer Survival

What is the meaning & survival rate of triple negative breast cancer? -Dr. Nanda Rajaneesh

Research over the years has generally shown that women under 40 years have a poorer than average prognosis. Interestingly, this factor is particularly relevant when the breast cancer is axillary node negative.

A medical study published in 2015 examined 4,453 Swedish women diagnosed with invasive breast cancer between 1961 and 1991 regarding age at diagnosis.

This research showed that women under 40 years had a higher mortality rate both for 5 year and 10 year survival rate.

However, older ladies between ages 70 and 79 and over 80 years had a higher mortality rate in both the 5 and 10 year follow up periods. The statistically worst outcome, after all adjustments for other factors, is for ladies over 80 years.

Furthermore, an earlier taken from SEER statistics between the years of 1988 to 2003 found that women under 40 years had lower rates of survival for stage I and II breast cancers.

Conversely, younger women tended to have a more favourable chance of survival at stage III and IV compared with those over 70 years of age.

Breast Cancer Subtypes Hormonal And Her2 Status

Although the term breast cancer is used in general, there are many different sub-types of breast cancers. The sub-types behave in different ways, with some responding better to treatments and some growing and spreading at faster rates.

Obviously, the sub-type of breast cancer affects survival rates.

There are 5 molecular types of breast cancer:-

  • Luminal A: This type of breast cancer is hormone receptor-positive and HER2 negative. Furthermore, Luminal A cancers tend to be low-grade and slow growing. These tumors respond well to hormone therapy.
  • Luminal B: These tumors are ER+ and can be HER+ or HER-. Luminal B cancers tend to grow faster, be of a higher grade and larger tumor size.
  • Triple negative/basal-like. As the name suggests these tumors are ER- PR- and HER-. Triple-negative breast cancers have a poorer prognosis and do not respond as well to treatment.
  • HER2-enriched: ER- PR- and HER2 positive. These tumors used to have a poor prognosis but since targeted therapy survival rates have improved.
  • Normal-like: These cancers are hormone receptor positive and HER2 negative. Normal-like breast cancers have a good prognosis.
  • History Of Breast Diseases

    The initial symptoms of cancer are cancerous lesions in the breast . Regarding the family history of disease, the other risk factors associated with breast cancer are in-situ carcinoma, atypical hyperplasia, proliferative lesions and non-proliferative lesions . Breast cancer risks include a family history of breast cancer and benign lesions .

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    What Are Cancer Survival Statistics

    A key part of making a prognosis is looking at survival rates. These are numbers researchers collect over many years in people with the same type of cancer. These numbers are based on large groups of people. For breast cancer, there are two main measurements:

    Breast cancer survivalrates reflect the percentage of women who are alive 5 years or longer after their diagnosis. This means the numbers are based on women who were found to have breast cancer at least 5 years ago. Advances in diagnosing and treating cancer have led to steadily improving survival rates, so the outlook for women diagnosed today is likely better.

    Relative survival rates donât take into account the cause of death. Theyâre a measure of the percentage of people with cancer who have lived for a certain time after diagnosis, compared with people who did not have cancer.

    Who Is Most Likely To Have Tnbc

    PPT

    Triple negative breast cancer appears more frequently in women age 40 and younger than in older women. Black and Latina women are more likely to develop TNBC than white women. Women who have the gene change BRCA1 are more likely to develop TNBC than other women. When the BRCA1 gene mutates, it stops preventing cancer and appears to make your bodys cells more vulnerable to cancer.

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    What Are The Mortality Rates For Breast Cancer

    Based on data from 2012 to 2018, the five-year relative mortality rate is 9.4%. That means 90.6% of people with female breast cancer are alive five years after diagnosis.

    The mortality rate for male breast cancer is higher, at 16%. That means that 84% of men who develop breast cancer will still be alive five years after diagnosis. The worse mortality rate in men is primarily due to later diagnosis of breast cancer in malesafter a lump has developed and cancer has spread from its original tissue.

    What Tumor Factors Threaten My Life More

    There are important tumor biology factors not well reflected in survival statistics by breast cancer stage. Below we list a few important factors that carry a higher risk to life beyond just the stage of cancer. You must ask your surgeon or medical oncologist to explain your receptor status and give you a copy of your biopsy pathology report.

    Triple Negative Receptor breast cancer

    Triple negative breast cancer is considered a more aggressive breast cancer. Invariably it does require chemotherapy. If you have triple negative breast cancer the risk of dying is higher than the standard statistics usually quoted for a particular stage of breast cancer . Learn more about Triple Negative Breast Cancer with our video lesson

    HER2-Positive breast cancer

    HER2-positive breast cancers are also more aggressive tumors. But the good news is that we now have incredibly effective, targeted chemotherapy and immunotherapy for HER2-positive cancers. Our video lesson covers HER2-Positive Breast Cancer in more detail .

    Breast Cancer at a Young Age

    Women younger than 40 have a higher chance of being diagnosed with a more advanced stage breast cancer. Also, the specific cancer type younger women develop has a higher chance of being more aggressive . As a result, age is a relative risk factor for survival.

    Untreated breast cancer

    Teaching everyone to be an expert in their own breast cancer care.

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    What Is The Prognosis For Triple

    A good treatment result depends on several factors. Chemotherapy is what can really make a difference in the outcome. The size of the invasive part of the tumor, and the number of involved lymph nodes can also greatly influence your prognosis, Sun says, but adds that if the cancer has spread , the prognosis is less certain.

    There is hope, even with this serious diagnosis, and staying optimistic is essential. It can be stressful and scary to go through chemo, but positive thinking can make a difference. You have to believe that its doing you good, and for most people, it does.

    Breast Cancer Treatment at Johns Hopkins

    The breast cancer program at Johns Hopkins is made up of a diverse group of nationally-recognized specialists in breast cancer research and treatment.

    How Do Breast Cancer Cells Spread Around The Body

    Triple Negative Breast Cancer

    Breast cancer cells travel through the body like any other cancer cells. Firstly, cancer cells can invade neighbouring healthy tissue. Following this, the cancer cells then invade local lymph nodes or blood vessels.

    When breast cancer spreads to the axillary lymph nodes this is still a relatively early stage of metastasis, and potentially curable.

    The cancer cells will typically travel through the lymphatic system or blood vessels to other distant parts of the body.

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    Progress In Treating Her2

    HER2-positive and triple-negative breast cancer are among the most aggressive forms of breast cancer and traditionally have had lower survival rates than other types of the disease. However, early detection with routine screening has contributed to improved survival for both in recent years. Further, treatment advancesall available at Regional Cancer Care Associates , one of the nations largest networks of cancer specialists with locations in New Jersey, Maryland, and Connecticutalso have helped improve outcomes in HER2-positive cancer. Meanwhile, intensive research and emerging therapeutic strategies are offering new hope for women with triple-negative breast cancer.

    Four RCCA medical oncologists recently explained what drives the development of these breast cancers, how they are treated, and how women can play an important and potentially life-saving role in identifying the cancers in their earliest stages, when they can be treated most effectively.

    Aileen Chen, MD, a board-certified medical oncologist practicing with RCCA in Freehold and Holmdel, NJ says, Its an exciting time in the fight against breast cancer. Next-generation sequencing technology is detecting genetic mutations that we can treat with targeted therapies in many forms of the disease. This has enhanced our ability to practice personalized medicine by customizing a patients treatment based on her molecular and genetic profiles.

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    More Than 3 Million Americans Live With Breast Cancer

    Many people know someone diagnosed with breast cancermillions have been diagnosed themself. Its the most commonly diagnosed cancer, other than skin cancer.

    Breast cancer is when cells in the breast tissue start to grow out of control and form a tumor. Breast cancer can develop in people of any sex but is much more common in those assigned female at birth.

    In 2022, there will be around 290,560 cases of breast cancer diagnosed in the U.S. .

    Thankfully, the survival rate for breast cancer is good and has been steadily improving over the last 30 years. More than 3.5 million women are currently living with breast cancer.

    This article will review the basic facts about breast cancerincluding how common it is, who gets it, and how likely it is to be deadly.

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    A Word On Survivorship Care Plans

    The details of your treatment and your scheduled monitoring can be a little overwhelming so thats why some people opt for a survivorship care plan.

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    A Note From Dr Halls Regarding The Statistics For Metastatic Recurrence In Breast Cancer

    Triple Negative Breast Cancer, " I Won

    The statistic of 20% to 30% for metastatic breast cancer that recurs remain controversial amongst medical experts. The figure of 30% metastatic breast cancer recurrence rate first appears in a 2005medical study, but no statistical data or sources are cited.

    The MBCN take the 18-year relative survival rate from the SEERS data between the years of 1990 to 1994 as 71%. The argument is, that this takes us close to the 30% recurrence rate statistic. However, there are many other factors at play and treatment has advanced so much that recurrence rates may have even halved since then.

    It is safe to say that much more data and research into metastatic recurrence rates would be of huge value towards a long-term cancer cure.

    Indeed, it has also been suggested that research into the rare group of women who survive many years with metastasis may be of equal importance to understanding recurrence and patterns of breast cancer.

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    What Are Symptoms Of Triple Negative Breast Cancer

    TNBC symptoms are the same as other common breast cancers. And many breast cancer symptoms are similar to other less serious conditions. That means having certain symptom doesnt mean you have breast cancer. Possible breast cancer symptoms include:

    • A new lump or mass.
    • Swelling in all or part of a breast.
    • Dimpled skin.
    • Nipple retraction, when your nipple turns inward.
    • Nipple or breast skin thats dry, flaking, thickened or red.
    • Nipple discharge that is not breast milk.
    • Swollen lymph nodes. This symptom happens when breast cancer spreads to the lymph nodes under your arm or near your collarbone.

    What Causes Triple

    Like most cancers, there isn’t a clear cause of triple-negative breast cancer. However, there are risk factors, including:

    • Being younger than 40: Unlike other breast cancers, triple-negative breast cancer is most often diagnosed in women who are younger.
    • Being Black or Latina: Black people are up to three times more likely than white people to have triple-negative breast cancer, when controlling for factors like age and obesity. Additionally, Hispanic people who develop breast cancer are more likely to have triple-negative breast cancer despite having a lower risk of breast cancer overall compared to other ethnicities.
    • Having a BRCA mutation: People with a BRCA gene mutation who develop breast cancer have about a 70% chance of having the triple-negative type. BRCA is a gene mutation that increases the risk for breast and ovarian cancers.

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    How Common Is Tnbc

    About 15-20 percent of all breast cancers are TNBC or basal-like tumors .

    TNBC tends to occur more often in :

    • Younger women
    • People with an BRCA1 inherited gene mutation
    • Black, non-Hispanic Black and African American women

    TNBC may also be more common among Hispanic women compared to non-Hispanic white women .

    Populations At Increased Risk For Tnbc

    Diet and Exercise with Triple-Negative Breast Cancer

    There are certain risk factors that put a woman at greater risk for TNBC. You may be at increased risk if:

    There are many factors that contribute to these racial disparities that are still unknown. However, Black and Hispanic patients are more likely to have unsatisfying communication with their doctors, experience discrimination in health-care settings and have a harder time getting to and from their appointments.

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    A New Era Of Hope For Patients With Triple

    Triple-negative breast cancer is a particularly devastating subtype of breast cancer, as it is often diagnosed in young women and is associated with an exceptionally poor prognosis. The triple-negative designation indicates that the three key features driving most breast cancers are lacking, but it provides no clues as to potential biologic drivers. In the absence of any biologic insights, tailored, targeted treatment decisions have historically not been possible.

    Consequently, until as recently as 2018, we have relied exclusively on nonselective cytotoxic agents, with modest success. For example, conventional neoadjuvant chemotherapy confers a pathologic complete response in just 50% to 55% of patients with early-stage triple-negative breast cancer,1-4 and among those who do not achieve a pathologic complete response, approximately one-third will die within 3 years.5 Moreover, patients with metastatic triple-negative breast cancer treated with conventional chemotherapeutics have a median survival of 12 to 18 months and an estimated 5-year overall survival of 11%.6 Thus, therapeutic innovation for early and late triple-negative breast cancer has been desperately needed.

    Biologic Insight Leads to Therapies

    From biologic insight springs hope for therapeutic innovation. Heather L. McArthur, MD, MPHTweet this quote

    Immune Modulation Via Checkpoint Blockade

    Antibody-Drug Conjugates

    Forecast Finally Changing in Triple-Negative Disease

    REFERENCES

    What Is The Survival Rate By Stage For Triple Negative Breast Cancer

    Survival rates are a way to discuss the prognosis and outlook of a cancer diagnosis. The number most frequently mentioned is 5-year survival. Many patients live much longer, and some die earlier from causes other than breast cancer. With constant change and improvement in therapies, these numbers also change. Current 5-year survival statistics are based on patients who were diagnosed at least 5 years ago and may have received different therapies than are available today.

    Below are the statistics from the National Cancer Institute’s SEER database for the survival of all patients with breast cancer, by tumor stage:

    5-Year Survival Rate by Stage

    Stage
    IV22%

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    Diagnosing Triple Negative Breast Cancer

    In many women the cancer is found during breast screening. But symptoms such as a breast lump can be a sign of breast cancer. So it is important to get any symptoms checked by your doctor.

    If you have symptoms and see your GP they refer you to a specialist breast clinic. At the breast clinic the doctor or breast care nurse takes your medical history and examines your breasts. They also feel for any swollen lymph nodes under your arms and at the base of your neck.

    You have some of the following tests:

    • a mammogram
    • an ultrasound
    • a biopsy your doctor or nurse take a small sample of cells or tissue from your breast to look at under a microscope

    Depending on your age and whether other family members have had breast cancer, your doctor might refer you for gene testing. This is to find out if there is a fault in the BRCA cancer gene.

    Signaling Pathway Of Cspg4 Protein

    Have cure for most deadly form of breast cancer, says Indian

    The CSPG4 protein is expressed as a cell surface proteoglycan by basal breast carcinoma cells. Therapeutically, CSPG4 inhibition allows for efficient management of breast cancer . Monoclonal antibodies can block the CSPG4 protein, which hinders survival signaling pathways in tumor cells. In addition, controlling the overexpression of CSPG4 by targeting it therapeutically is seen in different TNBC cells .

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