HomeWhat Is The Survival Rate Of Metastatic Breast Cancer

What Is The Survival Rate Of Metastatic Breast Cancer

Stage 1b Breast Cancer Means One Of The Following Descriptions Applies:

A New Breast Cancer Treatment Could Be A Game Changer

Lymph nodes have cancer evidence with small clusters of cells between the approximate size of a pinprick to the approximate width of a grain of rice .

AND EITHER No actual tumor is found in the breast.

OR The tumor is smaller than the approximate size of a peanut .

Similar to stage 0, breast cancer at this stage is very treatable and survivable. When breast cancer is detected early, and is in the localized stage , the 5-year relative survival rate is 100%.

Facts About Metastatic Cancer Survival Rate

Metastatic cancer survival rate is very important to patients. This refers to how they can deal with the cancer in order to survive. Prognosis of any cancers especially at this point is extremely relevant.

Metastatic Cancer Survival Rate

The hope to survive is what patients are concerned about. Surviving from metastatic cancer is the goal of every patient.

Metastatic cancer, which is also known as metastasis, is the spreading of cancerous cells to various organs and other tissues. These cells extend through the blood stream. If cancer cells begin to spread, other organs become affected which may result to damage. Generally, this condition exists during later stages. The essential thing that you must consider is the malignant cells. These cells should be well controlled so the disease will not worsen. Treating this disease right way is vital so metastatic cancer survival rate lung cancer, brain cancer or no matter what type would increase.

Improving metastatic cancer survival rate uterine is not difficult at all. With complete and proper treatments, any patient of uterine cancer at this late stage can still have a huge chance of surviving. The survival rate of this type of cancer is not that low at all compared to others such as brain and liver cancer. Metastatic cancer survival rate brain and metastatic cancer survival rate liver are somewhat lower than metastatic uterine cancer.

Our Advice To Other Women With Metastatic Breast Cancer: Be Nice To Yourself

Give yourself a break! is the advice that Sendelbach offers. Stop negative self-talk about what you should have done but didnt do, she says. If you have MBC, you need to be kind and loving to yourself.

The body has only so much energy to offer per day, and managing metastatic breast cancer requires a lot of it. So it doesnt make sense to try to compare what youre able to do with what your cancer-free friends are accomplishing.

Just getting through the day can be hard, Sendelbach says. Getting rid of those not good enough feelings can lift a huge weight off you.

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A Note About Statistics

Survival rates are statistics. As such, they tend to tell us how the average person will do with an average triple-negative breast cancer. But people and tumors arent statistics. Some people will do better, and some people will do worse.

Very importantly, statistics are usually several years old. In order to calculate five-year survival rates, a person would have to have been diagnosed at least five years prior, and there is lag time. The treatment of triple-negative breast cancer is changing, and new drugs have been approved.

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More Women Are Living With Metastatic Breast Cancer And Living Longer

According to research from the National Cancer Institute , the number of women living with metastatic breast cancer in the United States is increasing at the same time, women with metastatic disease are living longer, especially younger women.

The research was published online on May 18, 2017 by the journal Cancer Epidemiology, Biomarkers & Prevention. Read the abstract of Estimation of the Number of Women Living with Metastatic Breast Cancer in the United States.

Metastatic breast cancer is breast cancer that has spread to parts of the body away from the breast, such as the bones or liver. Metastatic breast cancer is stage IV cancer. A woman can be diagnosed with metastatic disease when first diagnosed. Breast cancer also can come back in a part of the body away from the breast. This is called metastatic recurrence.

“Even though this group of patients with metastatic breast cancer is increasing in size, our findings are favorable,” said Angela Mariotto, Ph.D., chief of the Data Analytics Branch of the Division of Cancer Control and Populations Sciences at the NCI. “This is because, over time, these women are living longer with metastatic breast cancer. Longer survival with metastatic breast cancer means increased needs for services and research. Our study helps to document this need.”

The study compared 5-year survival rates from 1992 to 1994 and from 2005 to 2012:

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Coping With Advanced Breast Cancer

Being told that you have advanced or metastatic breast cancer may be very confronting or overwhelming. Some women also find the news that their cancer has spread or come back is more devastating than their original diagnosis.

There are many resources available online to help you further understand the meaning of your diagnosis and how to manage the emotional, physical and practical issues arising from metastatic breast cancer. Below are some links where these resources can be accessed:

Connecting and speaking with others who have gone through a similar experience can also be helpful. Cancer Council runs support groups all across Australia which can provide support and information for people with cancer and their families. Groups in each state can be accessed here:

Although support groups can provide a safe place for people to express their feelings amongst others who share a similar experience, some people are more comfortable talking one-on-one, such as with a counsellor, therapist or trained volunteer . Your GP can also refer you to a psychologist, social worker or other trained therapist. Every person is different and it is important to find a healthy support system that works for you.

Are There Any Statistics On Recurrence Rates Or Incidence Of Metastasis

As mentioned, it is very difficult to find statistics on metastatic breast cancer that has recurred after initial diagnosis. However, these cases represent a large proportion of Stage IV breast cancer cases and overall deaths.

Most of the statistical data on Stage IV or metastatic breast cancer is from those women presenting at diagnosis. According to the Metastatic Breast Cancer Network in 2012 new cases of Stage IV breast cancer were between 13,776 to 22,096.

The number of breast cancer recurrences at Stage IV is estimated to be between 20% and 30% of all breast cancer diagnoses.

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Medications For More Severe Bone Pain

Tramadol or opioids can be added if the ibuprofen, naproxen or acetaminophen alone dont relieve the pain.

All of these drugs can cause constipation, so you may need to make some changes in your diet or take medications to promote regular bowel movements. For example, your health care provider may recommend eating high-fiber foods and drinking plenty of liquids to manage constipation.

Other side effects of these drugs include sleepiness and nausea. These usually go away after about a week. If they dont, tell your health care provider. These side effects can be treated.

If youre prescribed opioid medications, your health care provider will carefully monitor the amount prescribed so you dont take too much. People may worry about taking opioid medications, fearing side effects or addiction. However, when used as prescribed, these drugs can offer a great deal of pain relief.

Learn more about opioids and other pain medications, their side effects and fear of addition.

Why Does My Provider Need To Test The Metastatic Tumor

Understanding Breast Cancer Survival Rates

Your care team will test the metastases to figure out the biology of the tumor, which can help guide your treatment plan. Providers may test tumors for:

  • Hormone receptor status: If the cancer is hormone receptor-positive, hormonal therapy may be your first treatment.
  • HER2 status: Human epidermal growth factor receptor 2 is a protein that is overexpressed on some breast cancer cells. HER2-positive cancer responds to specific HER2-targeted therapies.
  • PIK3CA gene mutation: If a tumor is hormone receptor-positive and HER2-negative, your provider may test for this gene mutation. Specific targeted therapies can be used to treat tumors with this mutation.
  • PD-L1 status: Tumors that are hormone receptive-negative and HER2-negative may be tested for PD-L1 status. If the PD-L1 test is positive, you may be recommended to receive a combination of immunotherapy and chemotherapy.

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Metastatic Breast Cancer Is Terminal

Metastatic breast cancer cant be cured and it is terminal. One thing I didnt know when I was first diagnosed is that breast cancer can only kill you if you have metastatic breast cancer, says Rosen, who explains that if your cancer remains in the breast, the tumor can be removed, but metastatic means it has spread outside the breast.

MBC is almost like a different disease than early-stage breast cancer, adds Ann Silberman, 60, from Sacramento, California, who was diagnosed in 2009. We are going to die. Our concerns are much different from those of a person who has a treatment that will be over . Someone in an earlier stage may worry about losing their hair which is understandable but they will return to their normal life at some point.

People with metastatic breast cancer expect to be on treatment for the rest of their lives. I dont think everyone understands that, Silberman says. I still get, When will your treatment be over? Well, its never going to be over.

What Is Stage Iv Cancer

Stage IV cancer is the most severe form of cancer in which cancer has spread to a distant part of the body from its origin. Thus, testicular cancer may have spread to the lungs and bones, thyroid cancer may have spread to the brain, and so on. It is also known as metastatic or advanced disease.

The staging system often used for most types of cancer is the American Joint Committee on Cancer TNM system. In these staging systems, three types of key information are used.

  • T : It refers to the size of the original tumor.
  • N : It describes whether cancer has spread to the lymph nodes.
  • M : It refers to the spreading of cancer to other parts of the body.

A number or the letter X is allocated to each factor. A higher number means the cancer is advanced. For instance, a T1 score refers to a smaller tumor than a T2 score. The letter X indicates that information could not be assessed. M1 indicates that cancer has spread to a distant part of the body.

The physician combines T, N, and M results and other factors specific to cancer to determine the stage of cancer for each person. Most cancer types have four stages: stages I-IV, with stages I and IV being the least severe and most severe forms of cancer, respectively. Some types of cancer also have a stage 0 .

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Sobrevida De Pacientes Con Cncer De Mama Avanzado Positivo Para Receptores De Estrgenos

  • 1Departamento de Hematología-Oncología. Escuela de Medicina. Pontificia Universidad Católica de Chile, Santiago, Chile.
  • 2Departamento de Cirugía Oncológica y Maxilofacial. Escuela de Medicina. Pontificia Universidad Católica de Chile, Santiago, Chile.
  • 3Departamento de Anatomía-Patológica. Escuela de Medicina. Pontificia Universidad Católica de Chile, Santiago, Chile.
  • 4Departamento de Radiología. Escuela de Medicina. Pontificia Universidad Católica de Chile, Santiago, Chile.
  • 5Centro de Cáncer. Pontificia Universidad Católica de Chile, Santiago, Chile.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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What Is The Life Expectancy For Stage 4 Breast Cancer

Stage 4 breast cancer life expectancy can vary depending on several factors. The following factors can affect your life expectancy with metastatic breast cancer:

  • Age
  • Amount of hormone receptors and HER2 receptors on cancerous cells
  • Tissues that the cancer has affected

There is still not a clear answer for how long can you live with stage 4 breast cancer because it can vary greatly from patient to patient. Other factors such as past and current treatments being used also can have an effect on the life expectancy for patients.

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Survival And Prognostic Factors

Median follow-up after diagnosis of metastatic disease was 37.1 months , with 302 patients being alive at the end of the follow-up period.

The median survival of patients with de novo metastatic breast cancer was 29.4 months compared with 21.1 months for patients with recurrent metastatic breast cancer .

When looking at the patients with recurrent metastatic breast cancer stratified by MFI, survival of those with de novo metastatic breast cancer was significantly better than for patients with MFI < 24 months . Survival of de novo metastatic breast cancer patients was not significantly different from the survival of recurrent metastatic breast cancer patients with MFI of > 24 months .

Survival after diagnosis of metastatic breast cancer for patients with de novo metastatic breast cancer and recurrent metastatic breast cancer with MFI < 24 months and recurrent metastatic breast cancer with MFI > 24 months.

The prognostic impact of the prognostic factors did not differ significantly for the three MFI groups . Therefore, the results could be pooled to obtain the final Cox proportional hazards model .

Er Pr Her2 And Ihc Subtypes

Information on ER, PR and HER2 status was obtained from pathology reports for the whole study period . From 2005 to January 2010, tumours were classified as ER negative if < 10% ER expression, and from February 2010 onwards if < 1% ER expression. PR-negative tumours were defined as < 10% PR expression throughout the study period. HER2 expression was routinely assessed with IHC and verified with in situ hybridization if the IHC results were borderline. We created six IHC subtypes: ER+PR+HER2, ER+PRHER2, ER+PR+HER2+, ER+PRHER2+, ERPRHER2+ and ERPRHER2 . Women with the rarer combinations ERPR+HER2 or ERPR+HER2+ were set to missing in the analysis . In total, n =21,786 women had known IHC subtype, while n =2351 women lacked information on ER, PR or HER2 status .

Table 1 Clinicopathologic characteristics by IHC subtype for women with invasive breast cancer, Norway 20052015 age 2074 years

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What Should I Ask My Healthcare Provider About Metastatic Breast Cancer

If youve been diagnosed with metastatic breast cancer, ask your provider:

  • What are my treatment options?
  • What is my prognosis?
  • What side effects can I expect?
  • Will complementary therapy help me feel better?
  • What if I want to stop treatment?
  • How can I feel my best during treatment?

A note from Cleveland Clinic

Metastatic breast cancer is advanced breast cancer. Providers classify it as stage 4 breast cancer. It happens when cancer cells, often left behind after previous breast cancer treatment, start to spread to other parts of the body. While there is no cure for metastatic breast cancer, treatment can prolong your life and help you feel better. There are many medications available, so if one treatment isnt working, your care team can try a different approach. If you notice any symptoms or dont feel your best, especially if youve undergone breast cancer treatment in the past, talk to your healthcare provider.

Last reviewed by a Cleveland Clinic medical professional on 04/14/2021.

References

I Have To Prioritize And Try Not To Sweat The Small Stuff

Survival Rate and Treatment for Breast Cancer Recurrence

For Sendelbach, each week begins with a list of her priorities. Obviously, getting to my doctors appointments is very important, she says. But if the clothes arent folded, is that a dire situation? Absolutely not!

Sendelbach has learned to make compromises: If her husband and son have to pick up their clean clothes from the couch, she can live with that.

I have learned, she says, to look at every situation and ask if this is going to truly make a difference in my day or my familys day for better or worse. If the answer is no, then that task might be left undone.

It wasnt always this way for Sendelbach, though. When she was first diagnosed with cancer, her son was just a year old and she had been married for only two and a half years. You know how it is when you first have a baby if everything isnt perfect, then the world is falling apart! she laughs. Now, to us we ate, were all still alive, the house is acceptable if were good, its all okay.

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What Is The Survival Rate For Stage 4 Breast Cancer

The five-year survival rate for stage 4 breast cancer will depend on many things, but the value seen most often is about 27%. It is important to remember that five-year survival rates are based upon diagnoses that occurred at least five years ago. I bring this up because of the amazing progress that is being made every day in cancer research. The data below-median survival time from diagnosis among age groups across time.

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Database And Patient Selection

Data were extracted from the recently released SEER database containing information of cancer patients diagnosed from 1975 to 2016. SEER*Stat software version 8.3.6 was used to access the database with permission from the SEER program office. A total of 17446 patients met the criteria of metastatic breast cancer who were diagnosed from 2010 to 2015 were screened out from the database. Subsequently, patients who met the following criteria were excluded: unknown race unknown histological grade stage T0, TX or NX breast cancer unknown specific surgery type unknown estrogen receptor , progesterone receptor , or HER2 status unknown information of distant metastasis unknown radiation information patients with incomplete follow-up patients with multiple primary cancer. Finally, 8097 metastatic breast cancer patients were included in this study. Of these patients, 5173 patients who were diagnosed from 2010 to 2013 were chosen as the training set, while 2924 patients diagnosed from 2014 to 2015 were used as the validation cohort. Subsequently, each cohort was further divided into two subgroups based on whether they had undergone locoregional surgical treatment or not. The flowchart of patient selection was shown in Figure 1.

Figure 1. Flowchart of data selection. SEER, Surveillance, Epidemiology, and End Results Program.

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