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Why Is Breast Cancer So Deadly

Treatment Should Begin Without Delay

Pancreatic cancer: Why is it so deadly?

;Inflammatory breast cancer needs treatment as soon as possible. However, because of the unique properties it is recommended that an oncologist with ;experience in inflammatory breast cancer heads the treatment and management team.

Management of inflammatory breast cancer requires a combined-modality approach to therapy.

Does Breast Pain Increase The Risk Of Breast Cancer

Though it’s uncommon, there are some painful breast conditions which may raise your risk. Both radial scars;and multiple or complex fibroadenomas increase your risk of breast cancer Many breast conditions which cause pain confer only a minimally increased risk of breast cancer, such as ductal ectasia, fat necrosis, a breast abscess, simple fibroadenomas, and others.

Screening For Breast Cancer

Women aged between 50 and 74 are invited to access free screening mammograms every two years via the BreastScreen Australia Program.

Women aged 40-49 and 75 and over are also eligible to receive free mammograms, however they do not receive an invitation to attend.

It is recommended that women with a strong family history of breast or ovarian cancer, aged between 40 and 49 or over 75 discuss options with their GP, or contact BreastScreen Australia on 13 20 50.

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A Disease No One Gets

Sadly, people donât âgetâ mets. In fact, a recent survey sponsored by Pfizer Oncology shows just how misunderstood it is. Sixty percent of the 2,000 people surveyed knew little to nothing about MBC while 72 percent believed advanced breast cancer was curable as long as it was diagnosed early. Even more disheartening, a full 50 percent thought breast cancer progressed because patients either didnât take the right treatment or the right preventive measures.

âTheyâve built an industry built on four words â early detection equals cure â and that doesnât even begin to define breast cancer,â said Schoger, who helped found Breast Cancer Social Media, a virtual community for breast cancer patients, caregivers, surgeons, oncologists and others. âWomen are blamed for the fate of bad biology.â

The MBC Alliance, a consortium of 29 cancer organizations including the biggest names in breast cancer , addressed this lack of understanding and support as well as what many patient advocates term the underfunding of MBC research in a recently published landmark report.

Men Get Breast Cancer Too A Mans Lifetime Risk Of Breast Cancer Is About 1 In 1000

Brest Cancer Stages

Many people do not realise that men have breast tissue and that they can develop breast cancer. But breast cancer is less common in men because their breast duct cells are less developed than those of women and because they normally have lower levels of female hormones that affect the growth of breast cells.

Fact 6

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Who Gets Breast Cancer

Breast cancer is the most common cancer among women other than skin cancer. Increasing age is the most common risk factor for developing breast cancer, with 66% of breast cancer patients being diagnosed after the age of 55.

In the US, breast cancer is the second-leading cause of cancer death in women after lung cancer, and it’s the leading cause of cancer death among women ages 35 to 54. Only 5 to 10% of breast cancers occur in women with a clearly defined genetic predisposition for the disease. The majority of breast cancer cases are “sporadic, meaning there is no definitive gene mutation.

Can Exercise Help Reduce My Risk Of Developing Breast Cancer

Exercise is a big part of a healthy lifestyle. It can also be a useful way to reduce your risk of developing breast cancer in your postmenopausal years. Women often gain weight and body fat during menopause. People with higher amounts of body fat can be at a higher risk of breast cancer. However, by reducing your body fat through exercise, you may be able to lower your risk of developing breast cancer.

The general recommendation for regular exercise is about 150 minutes each week. This would mean that you work out for about 30 minutes, five days each week. However, doubling the amount of weekly exercise to 300 minutes can greatly benefit postmenopausal women. The longer duration of exercise allows for you to burn more fat and improve your heart and lung function.

The type of exercise you do can vary the main goal is get your heart rate up as you exercise. Its recommended that your heart rate is raised about 65 to 75% of your maximum heart rate during exercise. You can figure out your maximum heart rate by subtracting your current age from 220. If you are 65, for example, your maximum heart rate is 155.

Aerobic exercise is a great way to improve your heart and lung function, as well as burn fat. Some aerobic exercises you can try include:

  • Walking.
  • Dancing.
  • Hiking.

Remember, there are many benefits to working more exercise into your weekly routine. Some benefits of aerobic exercise can include:

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How Can I Protect Myself From Breast Cancer

Follow these three steps for early detection:

  • Get a mammogram. The American Cancer Society recommends having a baseline mammogram at age 35, and a screening mammogram every year after age 40. Mammograms are an important part of your health history. Recently, the US Preventive Services Task Force came out with new recommendations regarding when and how often one should have mammograms. These include starting at age 50 and having them every two years. We do not agree with this, but we are in agreement with the American Cancer Society and have not changed our guidelines, which recommend yearly mammograms starting at age 40.
  • Examine your breasts each month after age 20. You will become familiar with the contours and feel of your breasts and will be more alert to changes.
  • Have your breast examined by a healthcare provider at least once every three years after age 20, and every year after age 40. Clinical breast exams can detect lumps that may not be detected by mammogram.

Why Is Breast Cancer So Deadly

Why is Pancreatic Cancer So Deadly?

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What Are The Risk Factors For Breast Cancer

Like many conditions, risk factors for breast cancer fall into the categories of things you can control and things that you cannot control. Risk factors affect your chances of getting a disease, but having a risk factor does not mean that you are guaranteed to get a certain disease.

Controllable risk factors for breast cancer

  • Alcohol consumption. The risk of breast cancer increases with the amount of alcohol consumed. For instance, women who consume two or three alcoholic beverages daily have an approximately 20% higher risk of getting breast cancer than women who do not drink at all.
  • Body weight. Being obese is a risk factor for breast cancer. It is important to eat a healthy diet and exercise regularly.
  • Breast implants. Having silicone breast implants and resulting scar tissue make it harder to distinguish problems on regular mammograms. It is best to have a few more images to improve the examination. There is also a rare cancer called anaplastic large cell lymphoma that is associated with the implants.
  • Choosing not to breastfeed. Not breastfeeding can raise the risk.
  • Using hormone-based prescriptions. This includes using hormone replacement therapy during menopause for more than five years and taking certain types of birth control pills.

Non-controllable risk factors for breast cancer

Is Breast Cancer Serious

Breast cancer is a serious disease. Although some types of breast cancer are curable – especially in the early stages – treatment can be long and difficult. Some breast cancers are less curable, especially once they spread to other body parts. About 20 percent of breast cancer patients die of the disease.

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When To See Your Doctor

It’s important to talk to your physician if you have breast pain from any cause.;Even if it’s not due to cancer, many women find that breast pain decreases their quality of life. In one study,15% of the women experienced breast pain at some time in their life that interfered with work and family activities. So, make sure to talk to your doctor if you are experiencing any suspicious discomfort.

Survival Rates For Breast Cancer

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Survival rates can give you an idea of what percentage of people with the same type and stage of cancer are still alive a certain amount of time after they were diagnosed. They cant tell you how long you will live, but they may help give you a better understanding of how likely it is that your treatment will be successful.

Keep in mind that survival rates are estimates and are often based on previous outcomes of large numbers of people who had a specific cancer, but they cant predict what will happen in any particular persons case. These statistics can be confusing and may lead you to have more questions. Talk with your doctor about how these numbers may apply to you, as he or she is familiar with your situation.

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Our Advice To Other Women With Metastatic Breast Cancer: Be Nice To Yourself

Give yourself a break! is the advice that Sendelbach offers. Stop negative self-talk about what you should have done but didnt do, she says. If you have MBC, you need to be kind and loving to yourself.

The body has only so much energy to offer per day, and managing metastatic breast cancer requires a lot of it. So it doesnt make sense to try to compare what youre able to do with what your cancer-free friends are accomplishing.

Just getting through the day can be hard, Sendelbach says. Getting rid of those not good enough feelings can lift a huge weight off you.

How Is Breast Cancer Treated

If the tests find cancer, you and your doctor will develop a treatment plan to eradicate the breast cancer, to reduce the chance of cancer returning in the breast, as well as to reduce the chance of the cancer traveling to a location outside of the breast. Treatment generally follows within a few weeks after the diagnosis.

The type of treatment recommended will depend on the size and location of the tumor in the breast, the results of lab tests done on the cancer cells, and the stage, or extent, of the disease. Your doctor will usually consider your age and general health as well as your feelings about the treatment options.

Breast cancer treatments are local or systemic. Local treatments are used to remove, destroy, or control the cancer cells in a specific area, such as the breast. Surgery and radiation treatment are local treatments. Systemic treatments are used to destroy or control cancer cells all over the body. Chemotherapy and hormone therapy are systemic treatments. A patient may have just one form of treatment or a combination, depending on her individual diagnosis.

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What Are The Symptoms Of Inflammatory Breast Cancer

Inflammatory breast cancer symptoms may include:

;; ;Breast swelling, which one breast is suddenly larger than the other;; ;Breast that feels warm to touch and may look infected;; ;Itching or shooting pain;; ;A dimpling of the breast skin that looks like an orange peel ;;; Ridges or thickening of the skin;; ;Flattened or discolored nipple;; ;Swelling in underarm or only on one side of neck;; ;Might feel lump, however lumps are not common in IBC

What Makes Ibc Different

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Inflammatory breast cancer accounts for only a tiny fraction of breast cancers, so its symptoms are less well known and the disease has received less attention from researchers. It also has different physical signs than other types of breast cancer; instead of a lump, IBC causes swelling and visible changes in the skin around the breast including redness and a dimpling of the skin called peau d’orange, which is French for the skin of an orange.

IBC also tends to show up in women at a younger age and spread more quickly than other types of cancer. And because the cancer cells have already grown into the skin by the time symptoms appear, its typically diagnosed at stage 3 or stage 4.

Unlike strides made against other types of breast cancer, there arent yet any targeted therapies against IBC.

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Data Paints A More Complete Picture

The U-M study analyzed data from the National Cancer Institutes known as Surveillance, Epidemiology, and End Results, or SEER. The analysis was unique in including not only patients who had a diagnosis of IBC based on pathology reports, but also those with clinical symptoms consistent with IBC bringing the number of patients included in the study to nearly 30,000.

The team included two epidemiologists from the U-M School of Public Health: Yaoxuan Xia and Bhramar Mukherjee, Ph.D., chair of the department of biostatistics and a member of the Rogel Cancer Center.

We found that in these additional patients, the incidence rates by race were consistent with previously reported trends. This gave us confidence that our method was uncovering additional cases that had gone underreported in the past or were possibly misclassified in previous analyses, says study senior author Sofia Merajver, M.D., Ph.D., director of the Breast and Ovarian Cancer Risk and Evaluation Program at the Rogel Cancer Center. So therefore we believe our study is able to offer the most comprehensive assessment of incidence and survival rates of IBC to date.

Does Breast Cancer Affect Women Of All Races Equally

All women, especially as they age, are at some risk for developing breast cancer. The risks for breast cancer in general arent evenly spread among ethnic groups, and the risk varies among ethnic groups for different types of breast cancer. Breast cancer mortality rates in the United States have declined by 40% since 1989, but disparities persist and are widening between non-Hispanic Black women and non-Hispanic white women.

Statistics show that, overall, non-Hispanic white women have a slightly higher chance of developing breast cancer than women of any other race/ethnicity. The incidence rate for non-Hispanic Black women is almost as high.

Non-Hispanic Black women in the U.S. have a 39% higher risk of dying from breast cancer at any age. They are twice as likely to get triple-negative breast cancer as white women. This type of cancer is especially aggressive and difficult to treat. However, it’s really among women with hormone positive disease where Black women have worse clinical outcomes despite comparable systemic therapy. Non-Hispanic Black women are less likely to receive standard treatments. Additionally, there is increasing data on discontinuation of adjuvant hormonal therapy by those who are poor and underinsured.

In women under the age of 45, breast cancer is found more often in non-Hispanic Black women than in non-Hispanic white women.

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Survival And Mortality Rates

Survival depends on mortality. You start with 100 percent of the people in the group.

100 percent mortality rate = survival rate

Say, the mortality rate in the group of people is 5 percent. Survival would be 95 percent .

Similarly, the number of people in a group who survive depends on the number of people who die. Say,;500 people are;in the group and 1 person dies. This means 499 people survived .

Survival For All Stages Of Breast Cancer

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Generally for women with breast cancer in England:

  • Around 95 out of every 100 women survive their cancer for 1 year or more after diagnosis
  • Around 85 out of every 100 women will survive their cancer for 5 years or more after diagnosis
  • Around 75 out of every 100 women will survive their cancer for 10 years or more after diagnosis

Cancer survival by stage at diagnosis for England, 2019Office for National Statistics

These statistics are for net;survival. Net survival estimates the number of people who survive;their;cancer rather than calculating the number of people diagnosed with cancer who are still alive. In other words, it is the survival of cancer patients after taking into account that some people would have died from other causes if they had not had cancer.

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Inflammatory Breast Cancer And Hormone Receptor Status

;Inflammatory breast cancer tumors often have;increasedangiogenesis and lymphangiogenesis.

Furthermore, IBC tumors also frequently show an overexpression of HER-2, RhoC GTPase, and NFB genes.

Inflammatory breast cancers are more likely to be negative for Estrogen receptor status; ;and/or progesterone receptor;status .

Inflammatory breast cancer tumors have a higher frequency of ER- and PR- tumors in comparison to other advanced breast cancer tumors.; Indeed, some studies show that up to 83% of IBC tumors are ER-. ;This tends to affect the efficacy of treatment as the tumors do not respond to hormone therapy.

Data from the Surveillance, Epidemiology and End Results database show a higher median survival rate in inflammatory breast cancer ;ER+ tumors ; compared with ER- tumors .

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The U.S. Food and Drug Administration has approved only four therapies to treat brain tumors, according to a 2014 report by PhRMA, an association representing leading biopharmaceutical and technology companies.

During human clinical trials spanning the past 17 years, 75 potential brain-cancer drugs were shown to be unsafe and or ineffective, while just three won FDA approval a 25-to-1 failure ratio, PhRMA reported.

As cancer researchers often admit: We have cured cancer in mice thousands of times already, but we’ve yet to do it in humans.”

Whatever we find is working in that mouse model may not translate well into humans, Treadwell said. We dont understand why were failing.

The largest obstacle to a drug breakthrough is the blood-brain barrier, a natural wall that separates circulating blood from brain fluid to protect the brain from bacteria, Treadwell said.

The very thing that keeps us healthy also prevents us from getting drugs to the tumors, Treadwell said. Sometimes, in clinical trials, we dont even know if some of the drugs that were putting in there are actually reaching the tumor.

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