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Does Collagen Supplements Cause Breast Cancer

Collagen Supplement Safe To Take If You Had Estrogen Positive Breast Cancer

Understanding the Role of Collagen in Breast Cancer

i came across this recently, “Scientists believe collagen promotes tumor growth because recurrent tumors have high levels of collagen and breast cancer patients with high levels of collagen in their tumors often have worse outcomes.” Apr 23, 2019

Hi ladies, did you find out from the doctor if it is okay to use collagen? I am four weeks post with tram flap reconstruction and was thinking of staring collagen to speed up recovery. Thanks. Irene , south africa

Thanks am starting first of year will check with my doctor next appointment

I have Triple Negative but I have been supplementing with Collagen for years to help my bones and joints. I am not sure how well it works because I still got Osteoperosis. It has a lot of health benefits but I have never heard of a hormone connection.

I take it. In the reading that i’ve done, i haven’t seen anything contraindicating it as a supplement. Anyone else???

Xenograft Experiment And In Vivo Colonization Experiments

For the xenograft experiment, 6-week old female SCID mice were randomly grouped and injected with 2×106 control or collagen XIII-silenced MDA-MB-231-luc-D3H2LN cells at 4th mammary fat pad. Tumors were measured with a caliper every other day. Tumor volume was estimated using the formula . Twenty five days after tumor cell implantation, the primary tumors are removed by surgery. To detect lung metastasis, bioluminescent images were taken at 3 weeks after primary tumor removal with in vivo imaging system .

First Talk To Your Doctor

Before you take any vitamin, mineral, or herbal supplement, talk to your doctor. Research is limited on supplements and studies show mixed results on the safety of supplements and breast cancer.

Any supplements after breast cancer treatment should be regulated by your oncologists, says Anita Johnson, MD, breast cancer program director at Cancer Treatment Centers of America in Atlanta. Your medical team knows your symptoms and your full medical history and can tell you what may be best for you.

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Is It Safe To Take Collagen Supplements

The answer is yes. The collagen in collagen products is safe for use in the body. However, it is important to note that collagen is not a good source of vitamin D. , and the collagen that is in your skin is also not good for you. It is best to avoid collagen-containing products if you are pregnant or breastfeeding.

Western Blot And Luciferase Reporter Assay

Why Do People Take Collagen?

Protein samples were harvested by using 2% SDS in PBS with protease inhibitor cocktail and NaF , NaVO4 . SDS gel electrophoresis, immunoblot and a LI-COR Odyssey Infrared Imaging System were employed for detecting the target protein as previously described . The Image Studio Lite software was used for quantification.

The Dual-luciferase reporter assay was performed as previously described . Briefly, MDA-MB-231cells or MCF10A cells were seeded into a 24-well plate at the density of 0.1×106/well. 24 h later the cells will reach 80% confluence. Then 0.5 g p3TP-lux and 0.025 g renilla plasmids were transfected into the cells using Fugene HD Transfection Reagent. The cells were starved before 5 ng/ml TGF- was added. The relative luciferase activity was defined as firefly luciferase activity normalized by renilla luciferase activity. The final results were normalized by the relative luciferase activity of the control vector pGL4.10.

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Discovery Helps Show How Breast Cancer Spreads

Collagen fiber alignment at the tumor boundary is predictive of prognosis. Fibers that tend to be perpendicular to the tumor surface encourage metastasis and indicate a poor prognosis. Fibers that run parallel to the tumor surface protect against cancer spreading. Tumors without DDR2 or SNAIL1 tend to show the protective parallel fiber alignment.

Researchers at Washington University School of Medicine in St. Louis have discovered why breast cancer patients with dense breasts are more likely than others to develop aggressive tumors that spread. The finding opens the door to drug treatments that prevent metastasis.

It has long been known that women with denser breasts are at higher risk for breast cancer. This greater density is caused by an excess of a structural protein called collagen.

We have shown how increased collagen in the breasts could increase the chances of breast tumors spreading and becoming more invasive, said Gregory D. Longmore, MD, professor of medicine. It doesnt explain why women with dense breasts get cancer in the first place. But once they do, the pathway that we describe is relevant in causing their cancers to be more aggressive and more likely to spread.

The results appeared online May 5 in Nature Cell Biology.

We had no idea DDR2 would do this, said Longmore, also a professor of cell biology and physiology. The functions of DDR2 are not well understood, and it has not been implicated in cancer and certainly not in breast cancer until now.

Are Collagen Supplements Safe

Unlike drugs, the FDA doesnt approve dietary supplements to prevent or treat medical conditions. And supplement manufacturers do not need to prove a new product is safe before selling it. However, the FDA does monitor serious adverse impacts of supplements after they hit the market.

The most significant concern with collagen supplements comes from how they are made. Unless labeled as vegan or plant-derived, most collagen supplements come from ground up connective tissue of fish, chicken, or pork. The main concern with collagen supplements derived from animals is that they may contain dangerous heavy metals or other contaminants.

A review of 11 collagen supplements by ConsumerLab found cadmium, a toxic heavy metal, in one brand. To ensure the purity of supplements you take, Consumer Reports recommends looking for products certified by, NSF International, or U.S. Pharmacopeia .

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Collagen 1 Promotes Bc Cell Survival

In order to determine whether the collagen 1 is involved in the survival of FCS-starved-MCF-7 and T-47D cells, we studied the cell mortality after seeding the cells on a 2D collagen 1 coating. We found a decrease in cell mortality in the presence of collagen 1 after 24 h and 48 h post-starvation with a greater effect at 48 h, when compared to plastic condition . Next, we analysed apoptosis in cells seeded or not on collagen 48 h post-starvation using double labelling Annexin V/IP. Figure Figure1B1B showed that apoptotic cell rate is reduced by collagen 1 in MCF-7 , and T-47D cells . Moreover, the collagen 1 reduced Bax expression level in both MCF-7 and T-47D cells without affecting that of Bcl2 . These data showed that in FCS-starvation condition, collagen 1 protected the cells against apoptosis.

Collagen 1 induced MCF-7 and T-47D cells survival under serum starvation

Collagen Side Effects Can Be Intense So Why Do People Take It

Patricia Keely on Collagen’s Role in Breast Cancer

Collagen is a protein our body produces up until a certain point that creates firm, supple, and tight skin, and it almost seems as though using it would be the equivalent of finding the fountain of youth.

This new staple ingredient seems almost too good to be true. So, we spoke with nutritionists and medical professionals about the health implications of taking or applying collagen to our bodies.

Read on as we go over the potential collagen side effects that can happen the next time you try it. However, some side effects can be harmful to your body, so be sure to consult your doctor before adding any sort of supplements to your day-to-day life.

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Weird Harmful Collagen Side Effects You Need To Know

By Elizabeth Blasi Written on May 06, 2022

It seems as though you can’t walk past an aisle at the store or notice a pop-up ad on your computer that doesn’t preach about the many collagen benefits. Whether it’s ingesting it or topically applying it, collagen products are the next big thing when it comes to cosmetics and the beauty world.

For those who are unaware of what it is, “collagen is the major insoluble fibrous protein in the extracellular matrix and in connective tissue.” That’s just saying that it’s super important in our connective tissue like bones, ligaments, and cartilage.

The most common use of collagen supplements is to improve skin.

One of the several studies done showed that women who took 2.5-5 grams of collagen for 8 weeks showed less dryness and more elasticity to their skin than their controlled peers.

Another study proved the supplement can be used to improve hair and nail growth, while others showed it helps to reduce joint pains and overall joint health. A particular collagen benefit is that it most likely won’t make you gain weight because the protein can make you feel full.

With these kinds of health benefits to taking the protein supplement, there’s no wonder adding more collagen to your routine is the newest trend.

Collagen side effects can be intense so why do people take it?

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Can Collagen Increase Testosterone

Yes. , a research team led by Dr. David J. Buss, professor of medicine at the University of California, San Francisco, found that the amount of collagen in the skin of men who have had a vasectomy increases with age. The researchers found the increase in collagen levels was greatest in men over the age of 50. They also found a correlation between the level of testosterone in their blood and the collagen level. This means that men with higher levels of the hormone are more likely to have a higher level in skin. Dr Bess said that this is a good thing because it means men are getting more testosterone. He added that it is important to remember that testosterone is not a steroid. It is an essential hormone that helps maintain the bodys normal functioning. In addition, it helps to maintain a healthy immune system. The more collagen you have, the more you can use to build muscle and maintain your health, Dr J Bress said.

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Can Supplements Prevent Breast Cancer From Coming Back

So far, theres no proof that any vitamin, mineral, or herbal supplement can treat breast cancer or prevent it from coming back.

To date, there are no studies which demonstrate that certain supplements will lower your risk of recurrence, Johnson says. They may help with symptoms, but there isnt enough research to support using them to prevent breast cancer.

But there are other things you can do to lower your risk of breast cancer coming back. Make these lifestyle changes:

  • Eat a healthy diet.

Can You Take Excessive Collagen Peptides

What to Expect During Chemotherapy Treatment

Numerous points in nature comply with a J-shaped contour way too much or insufficient are both negative. The very same may be true for collagen supplements, yet sadly, theres no indication of what would comprise excessive. Theres additionally no evidence that collagen poisoning is a worry if you following dosing guidelines.

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Does Low Estrogen Affect Collagen

In estrogen deficient women skin thickness is reduced by 1.13% and collagen content by 2% per postmenopausal year. Type I and III skin collagen is thought to decrease by as much as 30% in the first five years after menopause,27,28 which parallels the reduction in bone mass observed in post-menopausal women.

Ecm Remodeling During Cancer Invasion

During cancer invasion, tumor stroma undergoes constant architectural changes, characterized by collagens degrading, re-depositing, cross-linking and stiffening in terms of ECM remodeling, and immune infiltration and re-differentiation of monocytes at the invasive front in terms of cellular changes.

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Can You Take Way Too Much Collagen Peptides

Lots of points in nature comply with a J-shaped curve excessive or insufficient are both bad. The same might be true for collagen supplements, however sadly, theres no sign of what would comprise excessive. Theres likewise no proof that collagen poisoning is a worry if you adhering to application standards.

The Relationship Among Exosomes Micrornas And Collagen In Cancer

The #1 Nutrient to Boost Your Collagen (NOT VITAMIN C)

Recent studies have highlighted the relationship among exosomes, microRNAs and collagen in cancer .

Exosomes are membrane-enclosed structures that facilitate communication between cancer cells and the ECM to influence cancer cell survival, growth, and metastasis and the immune system . Cancer-derived exosomes induce the formation of CAFs in the collagen matrix to promote EMT and increase the secretion of MMP-14 to regulate collagen . In addition, collagen enhances exosome secretion . Collagen and exosomes form a mutually beneficial feedback loop to promote cancer progression.

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Kv101 And Orai1 Staining

MCF-7 cells were gently and briefly washed with buffer containing 1 mM MgCl2, 100 mM KCl and 20 mM HEPES at 37°C. Then the cells were fixed and permeabilizated using 4% paraformaldehyde in PBS supplemented with 40 g/mL digitonin for 10 min. Before staining, cells were washed three times with PBS and treated for 45 min with 10% normal goat serum at room temperature for non-specific sites saturation. The anti-Kv10.1 and the anti-Orai 1 antibodies were added at 1:100 dilution for 1 hour. Then, after a second NGS treatment, a secondary AlexaFluor® 633 conjugate antibody was used at 1:100 dilution for Orai1 detection . For Kv10.1 detection, a biotinylated anti-goat secondary antibody was first used at 1:50 dilution . Then, the cells were treated with a streptavidin AlexaFluor® 488 conjugate antibody at 1:500 dilution .

Does Collagen Affect Estrogen Levels

Yes, collagen is a protein that is found in the skin. It is also found on the inside of the body. , and, but, it is not found inside the vagina. The skin is the most important part of your body, so its important to get enough collagen to keep your skin healthy. If you have a lot of collagen in your vagina, you may have problems with your period. You may also have issues with the way your menstrual cycle works. In addition, if you are having problems getting enough estrogen, then you might have an issue with vaginal dryness. This is because estrogen is produced in a way that makes it difficult for the vaginal lining to absorb it. So, the more estrogen you get, or the less estrogen your vaginal system can absorb, your dry vagina will get worse.

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Flow Cytometry Analysis Apoptosis

Poly-HEMA pre-coated dishes were used for detachment cell culture . MCF-10A and MDA-MB-231 cells were cultured in regular media with 0.5% methyl cellulose in suspension at a density of 30,000 cells per cm2 . Cells were cultured in suspended condition for 24 h. And then were collected for annexin V analysis as manufacturers instructions.

It May Cause Kidney Stones


One big collagen side effect on kidneys is the possibility of developing kidney stones.

According to Schoenfeld, “If a person has a history of calcium oxalate kidney stones, it is a good idea to take it slow when adding collagen to the diet, starting with no more than 5-6 grams per day .

One of the amino acids that collagen is rich in, hydroxyproline, can be converted into oxalate and excreted through the kidneys into the urine. Under the right circumstances, this could trigger a kidney stone to form. Always drink plenty of water when adding collagen to the diet.”

It may take a beating to your kidneys, but there are rarely any collagen side effects on livers. So, yay?

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How Long Does It Take For Collagen To Work

It depends what youre taking collagen to sustain. If youre taking collagen for muscle growth, favorable adjustments will begin to occur nearly instantly with your workouts although you may not discover the progression immediately.

In research studies checking out collagen supplements for joint discomfort and skin elasticity, individuals experienced recognizable improvements in concerning 4 to eight weeks of daily supplementation.

Like any supplement, collagen isnt an overnight miracle treatment but sticking with an everyday supplement routine will create the very best outcomes.

Basic Structure And Function Of Collagen

Biosynthesis of collagen. Three polypeptide -chains each including an N- and C-terminal propeptides form triple helical structures called procollagen triple helix by lysly hydroxylase, protein disulfide isomerase and hydrogen bonds. Neutral strands are stable, but charged forms are unstable. Tropocollagen triple helix is formed as N- and C-terminal propeptides are converted into N- and C-terminal peptides by N- and C-proteinases. Under lysyl oxidase cross-linking and self-assembly, collagen fibers or networks are formed

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Stiffer Collagen Matrices Inhibit Collective Invasion

Fig. 4: Collagen network stiffening reduces collective invasion but promotes single cell dissemination.

A IDC or ILC MDO cells were seeded in collagen matrices polymerized at 37°C or pre-polymerized at 26°C, and network stiffening was induced using AGE crosslinkers . Scale bar denotes 100µm. B, C Quantification of the invading strands of the IDC PyMT MDO . B Quantification of the length of invading strands of the IDC PyMT MDO . C Quantification of length of invasion of the ILC MDO as defined by major axis of ellipse. Invasive lengths in B and C were normalized to the 37°C control condition . Invasive strand length was normalized to the 37°C control conditions . D Confocal images were obtained from IDC MDO model in Collagen matrices, polymerized at 37°C or pre-polymerized at 26°C and stiffened using AGE crosslinkers. Organoids were stained for F-actin and Collagen . E Collagen alignment in was quantified in the region 050µm from the invasive leader cells after 3 days. Collagen was considered aligned at a 0.2 cut-off . Statistical significance was assessed by the MannWhitney test. Error bars show standard error of the mean. ***p< 0.005. All experiments are biological replicates and were replicated at least three times.


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