A Study Of Autogene Cevumeran As A Single Agent And In Combination With Atezolizumab In Participants With Locally Advanced Or Metastatic Tumors
Sorry, in progress, not accepting new patients
This is a Phase 1a/1b, open-label, multicenter, global, dose-escalation study designed to evaluate the safety, tolerability, immune response, and pharmacokinetics of autogene cevumeran as a single agent and in combination with atezolizumab .
San Francisco, California and other locations
Basket Study Of Entrectinib For The Treatment Of Patients With Solid Tumors Harboring Ntrk 1/2/3 Ros1 Or Alk Gene Rearrangements
Sorry, not currently recruiting here
This is an open-label, multicenter, global Phase 2 basket study of entrectinib for the treatment of patients with solid tumors that harbor an NTRK1/2/3, ROS1, or ALK gene fusion. Patients will be assigned to different baskets according to tumor type and gene fusion.
San Francisco, California
Other Types Of Immunotherapy In Breast Cancer
While there are not currently any other immunotherapy drugs approved for breast cancer, a number of methods are being evaluated in clinical trials.
Myths surrounding clinical trials abound, and many people express anxiety about participating. It’s important to keep in mind that every therapy we currently have approved was once studied in a clinical trial.
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Atezolizumab + Sacituzumab Govitecan To Prevent Recurrence In Tnbc
open to eligible people ages 18 years and up
The purpose of this study is to determine if a combination of two drugs ipatasertib and atezolizumab works as a treatment for residual cancer in the breast or lymph nodes and have circulating tumor DNA in the blood. This research study involves the following investigational drugs: – Sacituzumab govitecan – Atezolizumab
San Francisco, California and other locations
Additional Support Program Via Text Messaging And Telephone
open to eligible females ages 18 years and up
This phase III trial compares an additional support program with usual care in making sure breast cancer patients take their endocrine therapy medication as prescribed . Medication adherence is how well patients take the medication as prescribed by their doctors, and good medical adherence is when patients take medications correctly. Poor medication adherence has been shown to be a serious barrier to effective treatment for hormone receptor positive breast cancer patients. Adding text message reminders and/or telephone-based counseling to usual care may increase the number of days that patients take their endocrine therapy medication as prescribed.
Berkeley, California
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Treatment Of Stage Iv Breast Cancer
Stage IV cancers have spread beyond the breast and nearby lymph nodes to other parts of the body. When breast cancer spreads, it most commonly goes to the bones, liver, and lungs. It may also spread to the brain or other organs.
For women with stage IV breast cancer, systemic drug therapies are the main treatments. These may include:
- Some combination of these
Surgery and/or radiation therapy may be useful in certain situations .
Treatment can often shrink tumors , improve symptoms, and help some women live longer. These cancers are considered incurable.
Hormone Therapy With Or Without Combination Chemotherapy In Treating Women Who Have Undergone Surgery For Node
Sorry, in progress, not accepting new patients
This randomized phase III trial studies the best individual therapy for women who have node-negative, estrogen-receptor positive breast cancer by using a special test , and whether hormone therapy alone or hormone therapy together with combination chemotherapy is better for women who have an Oncotype DX recurrence score of 11-25. Estrogen can cause the growth of breast cancer cells. Hormone therapy may fight breast cancer by blocking the use of estrogen by the tumor cells or by lowering the amount of estrogen the body makes. Drugs used in chemotherapy work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving hormone therapy together with more than one chemotherapy drug has been shown to reduce the chance of breast cancer recurrence, but the benefit of adding chemotherapy to hormone therapy for women with node-negative, estrogen-receptor positive breast cancer is small. New tests may provide information about which patients are more likely to benefit from chemotherapy.
San Francisco, California and other locations
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A Phase 1 Study Of Pegilodecakin In Participants With Advanced Solid Tumors
Sorry, in progress, not accepting new patients
This is a first-in-human, open-label, dose escalation study to evaluate the safety and tolerability of pegilodecakin in participants with advanced solid tumors, dosed daily subcutaneously as a monotherapy or in combination with chemotherapy or immunotherapy.
San Francisco, California
Coping With Stage 4 Breast Cancer
It is natural to feel depressed, anxious, or even angry when you have been diagnosed with stage 4 breast cancer. It can leave you feeling as if you have no control over your health or future. Moreover, you may find that certain people will withdraw from you or suggest that you have metastatic cancer because you “left it too long.”
It is important to shield yourself from these negative emotions and embrace people who can provide you with genuine support. These include loved ones, support groups, and your oncology team. If you are unable to cope, ask for a referral to a therapist who can provide you counseling or a psychiatrist able to dispense treatment.
With that being said, there are women who experience positive emotional growth after being diagnosed with stage 4 breast cancer. It is not uncommon to hear someone say that cancer helped prioritize their life, allowing them to pursue what is truly important and connect with people on a deeper, more profound level.
Whatever your experience, don’t go it alone. Seek support and work with your medical team as a full partner in your care.
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Immunotherapy For Breast Cancer
Immunotherapy is the use of medicines to boost a persons own immune system to recognize and destroy cancer cells more effectively. Immunotherapy typically works on specific proteins involved in the immune system to enhance the immune response. These drugs have side effects different from those of chemotherapy.
Some immunotherapy drugs, for example, monoclonal antibodies, work in more than one way to control cancer cells and may also be considered targeted therapy because they block a specific protein on the cancer cell to keep it from growing.
Immunotherapy is used to treat some types of breast cancer.
Analysis Of Surgery In Patients Presenting With Stage Iv Breast Cancer
Sorry, in progress, not accepting new patients
The purpose of this study is to study patients presenting with stage IV breast cancer. Stage IV means that the breast cancer has spread to another part of the body outside the breast. This study is important because in different parts of the country some patients are being offered surgical treatment for the breast tumor and some are not. The doctors do not know if surgery for the breast tumor is helpful in patients with stage IV breast cancer. The doctors will collect information about the patient and their treatment to learn more about how patients and doctors make treatment decisions. The doctor will also collect blood samples and tissue samples for laboratory studies to learn more about tumors that have spread to other parts of the body.
San Francisco, California
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Study Of Radiation Fractionation On Patient Outcomes After Breast Reconstruction For Invasive Breast Carcinoma
Sorry, in progress, not accepting new patients
This study is a randomized trial of hypofractionation radiation therapy versus conventional radiation therapy in women who have undergone mastectomy and immediate breast reconstruction. The investigators will assess cosmetic and reconstruction outcomes, lymphedema, cancer status, side effects, and oncologic outcomes.
San Francisco, California and other locations
Stage 4 Cancer Prognosis
After a stage 4 cancer diagnosis, its normal to want to learn more about survival rates. Survival rate estimates for patients with cancer vary based on several factors, including:
- Type of cancer
- Overall health before beginning cancer treatment
- Grade of the cancer
Although the overall prognosis may be poor based on cases with previous patients and older treatments, many patients with stage 4 cancer can live for years.
A few factors to keep in mind:
- Many treatments are available to help fight cancer.
- Your bodys response to treatment may differ from that of others.
- Youll be able to share decision-making with your care team at each stage of treatment.
Advanced cancer treatments may be used to help treat symptoms, slow the cancers growth and improve quality of life. Additionally, having the appropriate support for you and your family can make a big difference.
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Recurrence Of Metastatic Breast Cancer
Metastatic breast cancer is considered a chronic disease, so it doesnt go away and recur.
But in recent years, people under age 50 have seen a particularly strong decline in death rates due to breast cancer, according to the Centers for Disease Control and Prevention .
These declines are due in part to improved screening and treatment for the disease.
There are a few general facts that are helpful to know about breast cancer outlook:
- Breast cancer is the most common cancer diagnosis in the United States, according to the
Expanded Access For The Treatment Of Cancers With Rearranged During Transfection Activation
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Expanded access for participants with cancer with RET activation who are ineligible for an ongoing selpercatinib clinical trial or have other considerations that prevent access to selpercatinib through an existing clinical trial. The treating physician/investigator contacts Lilly when, based on their medical opinion, a patient meets the criteria for inclusion in the expanded access program.
San Francisco, California
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A Safety Study Of Sea
open to eligible people ages 18 years and up
This trial will look at a drug called SEA-TGT to find out whether it is safe for patients with solid tumors and lymphomas. It will study SEA-TGT to find out what its side effects are. A side effect is anything the drug does besides treating cancer. It will also study whether SEA-TGT works to treat solid tumors and lymphomas. The study will have three parts. Part A of the study will find out how much SEA-TGT should be given to patients. Part B will use the dose found in Part A to find out how safe SEA-TGT is and if it works to treat solid tumors and lymphomas. Part C will study how well SEA-TGT with sasanlimab works to treat solid tumors.
San Francisco, California
Suppression Of Ovarian Function With Either Tamoxifen Or Exemestane Compared With Tamoxifen Alone In Treating Premenopausal Women With Hormone
Sorry, in progress, not accepting new patients
RATIONALE: Estrogen can stimulate the growth of breast tumor cells. Ovarian function suppression combined with hormone therapy using tamoxifen or exemestane may fight breast cancer by reducing the production of estrogen. It is not yet known whether suppression of ovarian function plus either tamoxifen or exemestane is more effective than tamoxifen alone in preventing the recurrence of hormone-responsive breast cancer.
PURPOSE: This randomized phase III trial studies ovarian suppression with either tamoxifen or exemestane to see how well they work compared to tamoxifen alone in treating premenopausal women who have undergone surgery for hormone-responsive breast cancer.
San Francisco, California
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Treatment Options For Stage 4 Cancer
Stage 4 cancer is challenging to treat, but treatment options may help control the cancer and improve pain, other symptoms and quality of life. Systemic drug treatments, such as targeted therapy or chemotherapy, are common for stage 4 cancers.
Often, a clinical trial may be an option, offering new treatments to help you fight stage 4 cancer.
Below are the prevailing treatment options for the five most common cancers.
Treatment of stage 4 breast cancer: For cancer that has spread beyond the breast and nearby lymph nodes, systemic drug treatments are typically used. These include:
- Hormone therapy
- Chemotherapy
- Immunotherapy
They may be used alone or in combination, and they may also be determined by the hormone receptor and the HER2 status of the cancer.
Surgery and radiation may be treatment options in specific cases to help improve symptoms caused by a growing tumor, not to get rid of the cancer. The tumor may be removed with surgery or shrunk by radiation therapy if, for example, its:
- Blocking a blood vessel
- Causing a wound
- Affecting the spinal cord
Treatment of stage 4 lung cancer: In general, stage 4 lung cancer is also treated with systemic drug therapies.
Stage 4 lung cancer that has spread to one distant area tends to be treated differently than lung cancer that has spread more widely. For stage 4A cancers, treatment tends to focus on the one site where the cancer has spread.
There may also be clinical trials assessing new treatments for stage 4 melanoma.
Prognosis For Metastatic Breast Cancer
Metastatic breast cancer isnt the same for everyone who has it. According to the National Breast Cancer Foundation, your symptoms at stage 4 will depend on the degree to which the cancer has spread in your body.
Although metastatic breast cancer has no current cure, it can be treated. Getting the right treatment can increase both your quality of life and longevity.
Life expectancy for breast cancer is based on studies of many people with the condition. These statistics cant predict your personal outcome each persons outlook is different.
The following factors can affect your life expectancy with metastatic breast cancer:
Read Also: What Happens If Breast Cancer Spreads To The Lymph Nodes
What Are Checkpoint Inhibitors
The immune system has certain checkpoints that help keep it from attacking normal cells in the body. These checkpoints can also weaken the immune systems attack on cancer cells.
Checkpoint inhibitors are drugs that prevent certain checkpoints from working. This makes the immune response stronger. The FDA has approved several drugs in this class for use in melanoma and metastatic lung cancer.
Clinical trials on checkpoint inhibitors used alone and in combination with other therapies are also underway for people with metastatic or triple-negative breast cancer.
In March 2019, the FDA approved the first immunotherapy drug combination for triple-negative breast cancer.
This drug combination includes the checkpoint inhibitor atezolizumab and the chemotherapy drug nab-paclitaxel .
Tecentriq blocks PD-L1, a protein that keeps the immune system from attacking cancer cells. Tecentriq is used together with Abraxane to maximize impact.
What Are Active Immunotherapies
Active immunotherapies essentially push your immune system to do more to respond to your cancer. Healthcare providers create these immunotherapies by examining your cancer cells for antigens. Antigens are toxins or foreign substances. When your immune system runs into an antigen, it goes after the antigen. By identifying cancer cell antigens, providers can create drugs that focus your immune system on the cancer cells.
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Immunotherapy And Breast Cancer
Recent studies have identified the presence of tumor infiltrating lymphocytes in breast tumor tissue to be a prognostic factor for the pathological complete response to neoadjuvant chemotherapy . With 1,058 patient biopsies, Dushyanthen et al., demonstrated higher post-NAC pCR rates in TIL+ tumors than TIL- tumors . In this study, more than 60% TILs were present in either the stromal or intratumoral component of the tissue. This response has also been documented in triple negative and HER-2 positive breast cancers.
Ali et al. conducted one of the largest breast cancer immunotherapy studies where 12,439 breast cancer cells were tested for CD8 and FOX3 immune markers. Breast cancer tissue with CD8+ T cells showed a 28% reduction in hazard of breast cancer-specific mortality in ER-negative tumors , 27% reduction of breast cancer-specific mortality in ER-positive/HER 2-positive tumors , but no difference in survival in the ER-positive tumors . The study concluded that some subgroups, such as ER-negative tumors and ER-positive/HER 2-positive tumors, could benefit from immune modulation .
Evaluation Of Lasofoxifene Versus Fulvestrant In Advanced Or Metastatic Er+/her2
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This is an open label, randomized, multicenter study evaluating the activity of lasofoxifene relative to fulvestrant for the treatment of pre- and postmenopausal women with locally advanced or metastatic ER+/HER2- breast cancer with an acquired ESR1 mutation and who have disease progression on an aromatase inhibitor in combination with a cyclin dependent kinase 4/6 inhibitor. The primary objective is to evaluate the progression free survival of 5 mg lasofoxifene relative to fulvestrant for the treatment of pre- and postmenopausal women with locally advanced or metastatic estrogen receptor positive /human epidermal growth factor 2 negative breast cancer with an estrogen receptor 1 mutation. The secondary objectives are to evaluate: 1. Clinical benefit rate and Objective Response Rate 2. Duration of response 3. Time to response 4. Overall Survival 5. Pharmacokinetics of lasofoxifene 6. Quality of life : Quality of Life : vaginal assessment scale and vulvar assessment scale questionnaires 7. Safety of lasofoxifene 8. Response to various ESR1 mutation .
San Francisco, California
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Tamoxifen Citrate Or Letrozole With Or Without Bevacizumab In Treating Women With Stage Iiib Or Stage Iv Breast Cancer
Sorry, in progress, not accepting new patients
This randomized phase III trial studies tamoxifen citrate or letrozole together with bevacizumab to see how well it works compared with tamoxifen citrate or letrozole alone in treating women with stage IIIB or stage IV breast cancer. Estrogen can cause the growth of breast cancer cells. Hormone therapy using tamoxifen citrate or letrozole may fight breast cancer by blocking the use of estrogen by the tumor cells. Immunotherapy with monoclonal antibodies, such as bevacizumab, may induce changes in the body’s immune system and may interfere with the ability of tumor cells to grow and spread. It is not yet known whether giving hormone therapy is more effective with or without bevacizumab in treating advanced breast cancer.
San Francisco, California