Breast Cancer Survival By Age
Five-year survival for female breast cancer shows an unusual pattern with age: survival gradually increases from 85% in women aged 15-39 and peaks at 92% in 60-69 year olds survival falls thereafter, reaching its lowest point of 70% in 80-99 year-olds for patients diagnosed with breast cancer in England during 2009-2013.
Breast Cancer , Five-Year Net Survival by Age, Women, England, 2009-2013
The Importance Of Screening
If youve been diagnosed with breast cancer, and especially if you have higher risk due to a hereditary gene mutation or other factors, screening can mean earlier detection of a recurrence or new breast cancer. Regular breast cancer screenings have been shown to reduce the risk of dying from breast cancer and increase survival rates.
Talk with your healthcare team about the type of screening plan thats best for you.
Below you can find articles, personal stories, and downloadable resources with more information about diagnosis, talking with family, and finding emotional support.
Symptoms Of Metastatic Breast Cancer
The symptoms of stage 4 breast cancer depend on the location of the cancer and where it has spread in your body.
- If breast cancer has spread to your bones, you may notice a sudden new bone pain. Breast cancer most commonly spreads to your ribs, spine, pelvis, or arm and leg bones.
- If it has spread to your brain, you may experience headaches, vision or speech changes, or memory problems.
- Breast cancer that has spread to your lungs or liver usually causes no symptoms.
The main treatments for stage 4 breast cancer are targeted drug therapies that destroy cancer cells wherever they are in your body.
These treatments may include:
- hormone therapy, which stops or slows the growth of tumors by preventing your body from producing hormones or interfering with the effect of hormones on breast cancer cells
- chemotherapy, where drugs given orally or through an IV travel through your bloodstream to fight cancer cells
- immunotherapy, which uses drugs that stimulate your immune system to destroy cancer cells
- a combination of these therapies
In some cases, surgery or radiation therapy may be used to treat stage 4 breast cancer.
The following are the common treatment options for different types of stage 4 breast cancer.
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Examples Of Mortality Rates Versus Number Of Deaths
Say, town A has a population of 100,000 and town B has a population of 1,000. Over a year, say there are 100 breast cancer deaths in town A and 100 breast cancer deaths in town B.
The number of breast cancer deaths in each town is the same. However, many more people live in town A than live in town B. So, the mortality rates are quite different.
In town A, there were 10 breast cancer deaths among 100,000 people. This means the mortality rate was less than 1 percent .
In town B, the mortality rate was 10 percent .
Although the number of deaths was the same in town A and town B, the mortality rate was much higher in town B than in town A .
Lets look at another example. In 2022, its estimated among women there will be :
- 100 breast cancer deaths in Washington, D.C.
- 730 breast cancer deaths in Alabama
- 4,690 breast cancer deaths in California
Of the 3, California has the highest number of breast cancers. However, that doesnt mean it has the highest breast cancer rate. These numbers dont take into account the number of women who live in each place. Fewer women live in Alabama and Washington, D.C. than live in California.
Other factors may vary by place as well, such as the age and race/ethnicity of women. So, to compare breast cancer mortality rates, we need to look at mortality rates.
In 2022, the estimated mortality rates are :
- 25 per 100,000 women in Washington, D.C.
- 21 per 100,000 women in Alabama 22
- 19 per 100,000 women in California 20
Prognosis And Survival For Breast Cancer
If you have breast cancer, you may have questions about your prognosis. A prognosis is the doctors best estimate of how cancer will affect someone and how it will respond to treatment. Prognosis and survival depend on many factors. Only a doctor familiar with your medical history, the type, stage and characteristics of your cancer, the treatments chosen and the response to treatment can put all of this information together with survival statistics to arrive at a prognosis.
A prognostic factor is an aspect of the cancer or a characteristic of the person that the doctor will consider when making a prognosis. A predictive factor influences how a cancer will respond to a certain treatment. Prognostic and predictive factors are often discussed together. They both play a part in deciding on a treatment plan and a prognosis.
Doctors use different prognostic and predictive factors for newly diagnosed and recurrent breast cancers.
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Metastasis Patterns And Prognosis Of Octogenarians With Metastatic Breast Cancer: A Large
- Zhenye Lv,
Roles Conceptualization, Methodology, Writing original draft
Affiliation Division of Breast Surgery, Department of General Surgery, Cancer Center, Zhejiang Provincial Peoples Hospital, Affiliated Peoples Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, China
- Wendan Zhang,
Roles Writing review & editing
Affiliation Department of Gynaecology and Obstetrics, The 903 Hospital of the Joint Logistics Support Force of the Chinese Peoples Liberation Army, Hangzhou, Zhejiang, China
- Yingjiao Zhang,
Roles Writing review & editing
Affiliation Department of Gastroenterology, The 903 Hospital of the Joint Logistics Support Force of the Chinese Peoples Liberation Army, Hangzhou, Zhejiang, China
-
Roles Methodology, Software
Affiliation Department of Breast Surgery, College of Medicine, The First Affiliated Hospital, Zhejiang University, Hangzhou, Zhejiang, China
For Family And Friends
Caring for a loved one with stage 4 breast cancer has special challenges as well. Fortunately, organizations such as CancerCare now offer support groups design for loved ones who are caring for someone with cancer. In addition to caring for yourself , it’s helpful to learn about metastatic breast cancer.
Common things that people learn about cancer usually refer to an early-stage disease, and myths about metastatic breast cancer can be painful for those living with advanced disease. For example, one of the things not to say to someone with metastatic breast cancer is, “When will you be done with treatment?”
For the most part, people with metastatic breast cancer will require some type of treatment for the rest of their lives.
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Why Does Metastatic Breast Cancer Happen
Most often, metastatic cancer occurs because treatment didnt destroy all the cancer cells. Sometimes, a few cells remain dormant, or are hidden and undetectable. Then, for reasons providers dont fully understand, the cells begin to grow and spread again.
De novo metastatic breast cancer means that at the time of initial diagnosis, the breast cancer has already spread to other parts of the body. In the absence of treatment, the cancer spreads.
There is nothing you can do to keep breast cancer from metastasizing. And metastatic breast cancer doesnt happen because of something you did.
Interactive Statistics With Seer*explorer
With SEER*Explorer, you can…
- Create custom graphs and tables
SEER*Explorer is an interactive website that provides easy access to a wide range of SEER cancer statistics. It provides detailed statistics for a cancer site by gender, race, calendar year, age, and for a selected number of cancer sites, by stage and histology.
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Can Metastatic Breast Cancer Be Cured
There is no cure for metastatic breast cancer. Once the cancer cells have spread to another distant area of the body, its impossible to get rid of them all. However, the right treatment plan can help extend your life and improve its quality.
Metastatic breast cancer treatment aims to shrink tumors, slow their growth and improve your symptoms.
What Should I Ask My Healthcare Provider About Metastatic Breast Cancer
If youve been diagnosed with metastatic breast cancer, ask your provider:
- What are my treatment options?
- What is my prognosis?
- What side effects can I expect?
- Will complementary therapy help me feel better?
- What if I want to stop treatment?
- How can I feel my best during treatment?
A note from Cleveland Clinic
Metastatic breast cancer is advanced breast cancer. Providers classify it as stage 4 breast cancer. It happens when cancer cells, often left behind after previous breast cancer treatment, start to spread to other parts of the body. While there is no cure for metastatic breast cancer, treatment can prolong your life and help you feel better. There are many medications available, so if one treatment isnt working, your care team can try a different approach. If you notice any symptoms or dont feel your best, especially if youve undergone breast cancer treatment in the past, talk to your healthcare provider.
Last reviewed by a Cleveland Clinic medical professional on 04/14/2021.
References
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What Is The Life Expectancy Of A Woman With Metastatic Breast Cancer
The 5-year survival rate for women with metastatic breast cancer is 29%. With proper treatment and care, some women can live up to 10 years or more after diagnosis.
Each patient is unique, however, and life expectancy depends on factors such as overall health, response to treatment, and where the metastasis occurs. In general, metastatic breast cancer is a terminal disease with no cure, and patients will need supportive care to prolong life expectancy and improve quality of life.
According to a study that compared 5-year survival rates from 1992-1994 to those from 2005-2012, the average survival rate of women under age 50 nearly doubled from 22.3 months to 39 months, and the average survival rate of women aged 50-64 increased from 19 months to almost 30 months.
Understanding Breast Cancer Survival Rates
Prognosis varies by stage of breast cancer.
Non-invasive and early-stage invasive breast cancers have a better prognosis than later stage cancers .
Breast cancer thats only in the breast and has not spread to the lymph nodes has a better prognosis than breast cancer thats spread to the lymph nodes.
The poorest prognosis is for metastatic breast cancer . This is when the cancer has spread beyond the breast and nearby lymph nodes to other parts of the body.
Learn more about breast cancer treatment.
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Relative Survival Rate By Stage
The survival rates by stage are based on the stage at the time of diagnosis. Youâve probably been given a number and letter for your cancer stage. Here, the terms localized, regional, and distant are used instead of numbers and letters. Hereâs what they mean and the 5-year relative survival rates for each:
- Localized breast cancer is only in the breast. This includes stage IA , some IIA , and some IIB . The 5-year relative survival rate is 99%.
- Regional breast cancer has spread to nearby tissue or lymph nodes. This includes stage IB , some IIA , some IIB , and all stage III . The 5-year relative survival rate is 86%.
- Distant breast cancer has spread to other parts of the body. This includes stage IV, pronounced âstage 4â). The 5-year relative survival rate is 28%.
Original Articleimpact Of Age At Diagnosis Of Metastatic Breast Cancer On Overall Survival In The Real
Young age is a poor prognosis factor in early stage breast cancer.
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Young age is associated with an aggressive presentation in metastatic breast cancer.
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Young age had no impact on overall survivall in metastatic breast cancer.
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Oppositely, older women had a stightly poorer prognosis at the metastatic stage.
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Importance Of Regular Screenings For Breast Cancer
Regular screening can also help improve survival rates by ensuring that breast cancer is detected and treated early.
A 2021 study reported that Black and Hispanic women actually met U.S Preventative Services Task Force breast cancer screening guidelines at a higher rate than white women.
However, the study also highlighted that not meeting the guidelines was associated with socioeconomic factors like lower income and lack of access to health insurance. Overall, public health agencies are trying to ensure that all women are able to receive timely screening and treatment.
Prognostic And Predictive Factors
Numerous prognostic and predictive factors for breast cancer have been identified by the College of American Pathologists to guide the clinical management of women with breast cancer. Breast cancer prognostic factors include the following:
- Axillary lymph node status
- Histologic subtypes
- Response to neoadjuvant therapy
- Estrogen receptor/progesterone receptor status
- HER2 gene amplification or overexpression
Cancerous involvement of the lymph nodes in the axilla is an indication of the likelihood that the breast cancer has spread to other organs. Survival and recurrence are independent of level of involvement but are directly related to the number of involved nodes.
Patients with node-negative disease have an overall 10-year survival rate of 70% and a 5-year recurrence rate of 19%. In patients with lymph nodes that are positive for cancer, the recurrence rates at 5 years are as follows:
- One to three positive nodes 30-40%
- Four to nine positive nodes 44-70%
- 10 positive nodes 72-82%
Hormone receptorpositive tumors generally have a more indolent course and are responsive to hormone therapy. ER and PR assays are routinely performed on tumor material by pathologists immunohistochemistry is a semiquantitative technique that is observer- and antibody-dependent.
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From Cured To Stage 4
Others, like Teri Pollastro, a 54-year-old stage 4 patient from Seattle, respond surprisingly well.
Diagnosed with early stage ductal carcinoma in situ in 1999, Pollastro underwent a mastectomy but did not receive chemotherapy, radiation or tamoxifen, since her cancer was ER negative.
âThey used the C-word with me, they told me I was cured,â she said. âEvery time I went back to my oncologist, he would roll his eyes at me when I had questions.â
In 2003, Pollastro switched to Seattle Cancer Care Alliance where she saw Dr. Julie Gralow, a breast cancer oncologist and clinical researcher at Fred Hutchinson Cancer Research Center. Gralow discovered Pollastroâs cancer had metastasized to her liver.
âMy husband and I were in shock,â said Pollastro of her mets diagnosis. âYou donât go from being cured to stage 4.â
Pollastro went on Herceptin, a type of immunotherapy for women with HER2-positive metastatic breast cancer, and did six months of chemotherapy.
âI felt better right away with the treatment,â she said. âBut the problem is, it stopped . Thatâs what you can expect with mets. And thereâs always some residual cancer. And that starts percolating.â
And along with mets, she also had to deal with many misconceptions regarding her disease.
The Mercer Island, Washington, mother of two, who often counsels newly diagnosed patients, sometimes even found it difficult to relate to early stage breast cancer survivors.
When Do People Get A Metastatic Breast Cancer Diagnosis
Metastatic breast cancer can occur at different points:
- De novo metastatic breast cancer: About 6% of women and 9% of men have metastatic breast cancer when theyre first diagnosed with breast cancer.
- Distant recurrence: Most commonly, metastatic breast cancer is diagnosed after the original breast cancer treatment. A recurrence refers to the cancer coming back and spreading to a different part of the body, which can happen even years after the original diagnosis and treatment.
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What Is Metastatic Breast Cancer
Metastatic breast cancer is also called stage IV or advanced breast cancer, in which the cancer has spread beyond the breast and adjacent lymph nodes to other parts of the body such as the bones, lungs, liver, or brain.
Remote recurrence occurs when metastatic breast cancer develops months or years after a person has finished therapy for early or locally advanced breast cancer.
Only 6% of women and 9% of men in the U.S. are diagnosed with de novo metastatic breast cancer, which refers to breast cancer that is already metastatic at the time of diagnosis.
Triple Negative Breast Cancer
With this type of breast cancer, the breast cancer cells dont have ER+ or PR+ receptors. They dont overproduce the HER2 protein, so hormone therapy isnt very effective.
Instead, triple negative stage 4 breast cancer is usually treated with chemotherapy. Radiation therapy may also be an option, depending on the site of metastasis.
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Breast Cancer Diagnosis And Survival Rates Over The Last 27 Years
The incidence of breast cancer has risen dramatically over the last 28 years, rising from about 9,827 new cases a year in 1994, to over 20,000 new cases a year in 2022. As a result, 1 in 7 women will now be diagnosed in their lifetime.
From NBCFs inception in 1994, five-year relative survival for breast cancer improved from 76% to 92%. This improvement is a result of research. But despite the improved survival rate, this year around 9 Australians will lose their lives to breast cancer every day. In 2022, there was over 3,200 deaths from breast cancer, including .
Unfortunately, despite improved survival rates, the number of deaths from breast cancer each year is still rising. This is being driven by the increase in diagnoses.
What Are The Symptoms Of Metastatic Breast Cancer
Symptoms of metastatic breast cancer are tricky because they vary depending on where the metastasis occurs. Some symptoms may be side effects of cancer treatment or a sign of stress or depression associated with the disease. It is crucial to investigate the cause.
Common symptoms of metastatic breast cancer include:
- Severe pain and swelling in the bones or the joints
- Weak bones
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